{"id":14811,"date":"2020-10-06T15:46:00","date_gmt":"2020-10-06T15:46:00","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=14811"},"modified":"2023-05-11T14:22:53","modified_gmt":"2023-05-11T12:22:53","slug":"dmt-u-deprese-rezistentni-na-lecbu","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/cs\/blog\/dmt-for-treatment-resistant-depression\/","title":{"rendered":"DMT pro l\u00e9\u010dbu rezistentn\u00ed deprese"},"content":{"rendered":"<h2 class=\"wp-block-heading\" id=\"h-dmt-for-treatment-resistant-depression\"><em>DMT pro l\u00e9\u010dbu rezistentn\u00ed deprese <\/em><\/h2>\n\n\n<p><strong>Je to probl\u00e9m, kter\u00fd dlouhodob\u011b prov\u00e1z\u00ed l\u00e9\u010dbu du\u0161evn\u00edho zdrav\u00ed, ani\u017e by p\u0159in\u00e1\u0161el slibn\u00e9 v\u00fdsledky. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3363299\/\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\">alternativy<\/a>. Jedn\u00e1 se o z\u00e1va\u017enou a chronickou p\u0159ek\u00e1\u017eku na cest\u011b k \u0159e\u0161en\u00ed krize du\u0161evn\u00edho zdrav\u00ed, kter\u00e1 postihuje t\u00e9m\u011b\u0159 <a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\">264 milion\u016f lid\u00ed<\/a> glob\u00e1ln\u011b.<\/strong><\/p>\n\n\n<h2 class=\"wp-block-heading\" id=\"h-enter-dmt\"><em>Vstupte na trh s DMT...<\/em><\/h2>\n\n\n\n<p>Biotechnologick\u00e1 spole\u010dnost ATAI Life Sciences se sna\u017e\u00ed \u0159e\u0161it problematiku deprese rezistentn\u00ed na l\u00e9\u010dbu. <strong><a href=\"https:\/\/viridia.life\/\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\">Viridia Life Sciences<\/a><\/strong> k v\u00fdvoji nov\u00fdch formulac\u00ed N,N-dimethyltriptyminu <em>(zn\u00e1m\u00fd tak\u00e9 jako psychedelick\u00e1 slou\u010denina<a href=\"https:\/\/www.healthline.com\/health\/what-is-dmt\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\"> <strong>DMT<\/strong><\/a>)<\/em> jako potenci\u00e1ln\u00ed l\u00e9\u010dba.&nbsp;<\/p>\n\n\n\n<figure><img decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/2020\/10\/Screen-Shot-2020-08-31-at-13.28.59-scaled-1.jpg\" alt=\"\" \/>\n<figcaption><mark>Foto s laskav\u00fdm svolen\u00edm: Little Atoms<\/mark><\/figcaption>\n<\/figure>\n\n\n\n<p>Spole\u010dnost Viridia nyn\u00ed pl\u00e1nuje studovat \u00fa\u010dinnost DMT s pomoc\u00ed <strong><a href=\"https:\/\/www.statnews.com\/2020\/02\/20\/digital-therapeutics-vs-digital-care\/\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\">digit\u00e1ln\u00ed terapie<\/a><\/strong>, co\u017e jsou programy nebo aplikace ur\u010den\u00e9 pro konkr\u00e9tn\u00ed stavy (nap\u0159. chronick\u00e1 obstruk\u010dn\u00ed plicn\u00ed nemoc (<a href=\"https:\/\/www.nhs.uk\/conditions\/chronic-obstructive-pulmonary-disease-copd\/symptoms\/\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\">CHOPN<\/a>) sp\u00ed\u0161e ne\u017e plicn\u00ed onemocn\u011bn\u00ed nebo deprese sp\u00ed\u0161e ne\u017e du\u0161evn\u00ed zdrav\u00ed).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-treating-resistant-depression-with-dmt\"><em>L\u00e9\u010dba rezistentn\u00ed deprese pomoc\u00ed DMT <\/em><\/h2>\n\n\n\n<p>Zn\u00e1m\u00fd tak\u00e9 jako <em>\"molekula ducha\"<\/em>, DMT se vyskytuje v rostlin\u00e1ch i zv\u00ed\u0159atech - v\u010detn\u011b lid\u00ed - a domorod\u00ed obyvatel\u00e9 jej po tis\u00edce let po\u017e\u00edvali k ritu\u00e1ln\u00edm \u00fa\u010del\u016fm (a ano, DMT se vyskytuje v rostlin\u00e1ch i zv\u00ed\u0159atech - v\u010detn\u011b lid\u00ed). <em>je<\/em> hlavn\u00ed \u00fa\u010dinnou l\u00e1tku v <a href=\"https:\/\/www.healthline.com\/nutrition\/ayahuasca\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\">ayahuasca<\/a>.<\/p>\n\n\n\n<p>Mezi psychick\u00e9 \u00fa\u010dinky DMT pat\u0159\u00ed:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Depersonalizace,<\/li>\n\n\n\n<li>Extr\u00e9mn\u00ed halucinace,<\/li>\n\n\n\n<li>Zm\u011bn\u011bn\u00fd smysl pro \u010das<\/li>\n\n\n\n<li>Pocit \"vzn\u00e1\u0161en\u00ed se\"<\/li>\n\n\n\n<li>Euforie.<\/li>\n<\/ul>\n\n\n\n<p>V\u00fdzkum nyn\u00ed uk\u00e1zal, \u017ee DMT m\u016f\u017ee l\u00e9\u010dit stavy, jako je \u00fazkost, posttraumatick\u00e1 stresov\u00e1 porucha a deprese - mo\u017en\u00e1 dokonce nab\u00edz\u00ed rychle p\u016fsob\u00edc\u00ed \u0159e\u0161en\u00ed pro rezistentn\u00ed deprese. Jak je to mo\u017en\u00e9?<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-here-s-how\"><em>Zde je n\u00e1vod, jak na to!<\/em><\/h2>\n\n\n\n<p>Testy in vitro<em> (kter\u00e9 se t\u00fdkaj\u00ed studia bun\u011bk nebo biologick\u00fdch molekul \"ve skle\", mimo jejich b\u011b\u017en\u00e9 hostitele).<\/em> u zv\u00ed\u0159ec\u00edch model\u016f prok\u00e1zaly r\u016fst nov\u00fdch mozkov\u00fdch bun\u011bk s v\u011bt\u0161\u00edm po\u010dtem spojen\u00ed. <em>(tzv. neuroplasticita)<\/em> po u\u017eit\u00ed DMT. Tyto p\u0159\u00edr\u016fstky jsou \u010dasto spojeny se zlep\u0161en\u00edm p\u0159\u00edznak\u016f deprese. \u00da\u010dinky DMT pozorovan\u00e9 na elektroencefalogramu <em>(EEG)<\/em> tak\u00e9 vykazovaly stejn\u00e9 zm\u011bny mozkov\u00fdch vln, o kter\u00fdch se kdysi tvrdilo, \u017ee pom\u00e1haj\u00ed p\u0159i depresi.<\/p>\n\n\n\n<figure><img decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/2020\/10\/Screen-Shot-2020-08-31-at-13.28.59-1-scaled-1.jpg\" alt=\"\" \/>\n<figcaption><mark>V\u00e1\u0161 mozek na DMT, jak je vid\u011bt na elektroencefalogramu <em>(EEG)<\/em> model. Foto s laskav\u00fdm svolen\u00edm:<strong> BioRxiv.org<\/strong><\/mark><\/figcaption>\n<\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-not-just-intravenously-new-ways-of-taking-dmt\"><em> Nejen intraven\u00f3zn\u011b: Nov\u00e9 zp\u016fsoby u\u017e\u00edv\u00e1n\u00ed DMT <\/em><\/h2>\n\n\n\n<p>A\u010dkoli se DMT \u010dasto pod\u00e1v\u00e1 intraven\u00f3zn\u011b, spole\u010dnost Viridia pl\u00e1nuje vytvo\u0159it n\u011bkolik produkt\u016f DMT zalo\u017een\u00fdch na jin\u00fdch zp\u016fsobech pod\u00e1n\u00ed. <strong>Glenn Short, PhD<\/strong>, gener\u00e1ln\u00ed \u0159editel spole\u010dnosti Viridias, vysv\u011btlil:<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><p><em> \"DMT pod\u00e1van\u00fd intraven\u00f3zn\u00ed kapa\u010dkou (IV) nem\u00e1 v\u017edy kr\u00e1tk\u00e9 trv\u00e1n\u00ed a je tak\u00e9 velmi intenzivn\u00ed. Na\u0161\u00edm c\u00edlem je vyu\u017e\u00edt chemick\u00e9 slo\u017een\u00ed prepar\u00e1tu tak, abychom dok\u00e1zali zpomalit n\u00e1stup \u00fa\u010dink\u016f slou\u010deniny a tak\u00e9 kontrolovat d\u00e9lku a trv\u00e1n\u00ed z\u00e1\u017eitku, aby byl pozvoln\u011bj\u0161\u00ed a celkov\u011b pro pacienta jemn\u011bj\u0161\u00ed a p\u0159\u00edjemn\u011bj\u0161\u00ed. M\u016f\u017eeme skute\u010dn\u011b jemn\u011b vyladit zp\u016fsob, jak\u00fdm se l\u00e9\u010divo uvol\u0148uje.\" <\/em><\/p><\/p>\n\n\n\n<p>To je dobr\u00e1 zpr\u00e1va pro pacienty s fobi\u00ed z jehel, proto\u017ee si mohou zvolit m\u00e9n\u011b invazivn\u00ed formu pod\u00e1n\u00ed DMT.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-pairing-dmt-with-psychotherapy-for-maximum-effect\"><em>Spojen\u00ed DMT s psychoterapi\u00ed pro dosa\u017een\u00ed maxim\u00e1ln\u00edho \u00fa\u010dinku <\/em><\/h2>\n\n\n\n<p>Spole\u010dnost Viridian pl\u00e1nuje vyu\u017e\u00edt kr\u00e1tk\u00e9ho polo\u010dasu rozpadu DMT na klinice k navozen\u00ed psychedelick\u00e9ho z\u00e1\u017eitku, po kter\u00e9m bude ihned n\u00e1sledovat psychoterapeutick\u00e9 sezen\u00ed.&nbsp;<\/p>\n\n\n\n<p>Tato kombinace se uk\u00e1zala jako nejp\u0159\u00ednosn\u011bj\u0161\u00ed pro zkouman\u00e9 osoby - jak uk\u00e1zala ned\u00e1vn\u00e1 metaanal\u00fdza 20 studi\u00ed \u00fazkosti a deprese, a to kombinac\u00ed psychedelick\u00e9 drogy s psychoterapi\u00ed.<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><p><em> \"DMT p\u0159edstavuje p\u0159\u00edle\u017eitost, jak oslovit ty, kte\u0159\u00ed nemohou nebo necht\u011bj\u00ed podstoupit del\u0161\u00ed psychedelick\u00fd z\u00e1\u017eitek.\" <\/em><\/p><\/p>\n\n\n\n<p>- Florian Brand, gener\u00e1ln\u00ed \u0159editel spole\u010dnosti ATAI Life Sciences.<\/p>\n\n\n\n<p>Tentokr\u00e1t v\u0161ak Viridias pou\u017eije <em>digit\u00e1ln\u00ed<\/em> terapie, kter\u00e1 n\u00e1sleduje po pod\u00e1n\u00ed DMT. Potenci\u00e1ln\u00ed subjekty mohou o\u010dek\u00e1vat \u0159adu specializovan\u00fdch aplikac\u00ed jako \"p\u0159\u00edmou komunika\u010dn\u00ed linku\" se sv\u00fdm terapeutem.<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><p><em>\"Spojen\u00edm digit\u00e1ln\u00ed terapie s terapi\u00ed DMT m\u016f\u017eeme subjekt na z\u00e1\u017eitek p\u0159ipravit p\u0159edem - ale m\u016f\u017eeme pacienta sledovat i po terapii. Pacient... si m\u016f\u017ee tak\u00e9 pov\u00eddat s dal\u0161\u00edmi lidmi, kte\u0159\u00ed podstupuj\u00ed stejn\u00fd typ l\u00e9\u010dby.\" <\/em><\/p><\/p>\n\n\n\n<p>- Glenn Short, PhD, gener\u00e1ln\u00ed \u0159editel spole\u010dnosti Viridias.<\/p>\n\n\n\n<p>Digit\u00e1ln\u00ed terapie umo\u017e\u0148uje terapeut\u016fm sledovat pacienta v re\u00e1ln\u00e9m \u010dase. Zaji\u0161\u0165uje tak\u00e9 trvalou podporu pacienta i mimo kliniku.<\/p>\n\n\n\n<p>Zaj\u00edmav\u00e9 je, \u017ee ani jedna ze studi\u00ed v r\u00e1mci studie <strong><a href=\"http:\/\/:https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/da.23065\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\">metaanal\u00fdza<\/a><\/strong> zjistil, \u017ee samotn\u00e1 l\u00e1tka je dosta\u010duj\u00edc\u00ed. To je kl\u00ed\u010dov\u00fd rozd\u00edl mezi u\u017e\u00edv\u00e1n\u00edm psychedelik v rekrea\u010dn\u00edm prost\u0159ed\u00ed a na klinice.  Spole\u010dnost prozat\u00edm podstoup\u00ed \u0159adu preklinick\u00fdch farmakologick\u00fdch a toxikologick\u00fdch studi\u00ed, ne\u017e je bude moci p\u0159edlo\u017eit k regulaci. Teprve pot\u00e9 bude moci spole\u010dnost Viridias p\u0159istoupit ke zkou\u0161k\u00e1m f\u00e1ze 1.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-implications-for-mental-health-in-2020\"><em>D\u016fsledky pro du\u0161evn\u00ed zdrav\u00ed v roce 2020<\/em><\/h2>\n\n\n\n<p>Sou\u010dasn\u00e1 pandemie COVID-19 uvrhla mnoho lid\u00ed do chudoby a izolace, co\u017e by, jak ned\u00e1vno varovala OSN, mohlo v\u00e9st k <strong>prohloubit krizi du\u0161evn\u00edho zdrav\u00ed<\/strong>.<\/p>\n\n\n\n<p>Bylo v\u0161ak zji\u0161t\u011bno, \u017ee mnoho p\u0159edepsan\u00fdch l\u00e9k\u016f na depresi, jako jsou SSRI, m\u016f\u017ee zp\u016fsobit.<a href=\"https:\/\/www.health.harvard.edu\/mind-and-mood\/what-are-the-real-risks-of-antidepressants\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"undefined (otev\u0159e se v nov\u00e9 z\u00e1lo\u017ece)\"> dal\u0161\u00ed probl\u00e9my s du\u0161evn\u00edm zdrav\u00edm<\/a>, jako nap\u0159. <em>\"zv\u00fd\u0161en\u00e9 sebevra\u017eedn\u00e9 my\u0161lenky, nep\u0159\u00e1telstv\u00ed a rozru\u0161en\u00ed\".<\/em> u d\u011bt\u00ed, dosp\u00edvaj\u00edc\u00edch a mlad\u00fdch dosp\u011bl\u00fdch.<\/p>\n\n\n\n<p>U mnoha pacient\u016f, kte\u0159\u00ed se sna\u017e\u00ed naj\u00edt stabilitu, m\u016f\u017ee neust\u00e1l\u00e9 st\u0159\u00edd\u00e1n\u00ed l\u00e9k\u016f Big Pharma zp\u016fsobit, \u017ee ztrat\u00ed pocit rovnov\u00e1hy a normality - co\u017e pak vede k obdob\u00ed relapsu. V takov\u00e9m p\u0159\u00edpad\u011b nejsou posti\u017eeni jen pacienti, ale jeho d\u016fsledky mus\u00ed \u010dasto trp\u011bt i jejich rodina. Alternativn\u00ed zp\u016fsoby l\u00e9\u010dby deprese, jako jsou psychedelika, jsou tedy v t\u00e9to nejist\u00e9 dob\u011b skute\u010dn\u011b nezbytn\u00e9.&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>V\u011bd\u011bli jste, \u017ee u mnoha lid\u00ed na sv\u011bt\u011b, kte\u0159\u00ed trp\u00ed depres\u00ed, zna\u010dn\u00e1 \u010d\u00e1st z nich nereaguje na \u017e\u00e1dnou l\u00e9\u010dbu?<\/p>","protected":false},"author":1,"featured_media":14815,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"topics":[],"class_list":["post-14811","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/14811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/cs\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/cs\/wp-json\/wp\/v2\/comments?post=14811"}],"version-history":[{"count":1,"href":"https:\/\/www.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/14811\/revisions"}],"predecessor-version":[{"id":123822,"href":"https:\/\/www.wholecelium.com\/cs\/wp-json\/wp\/v2\/posts\/14811\/revisions\/123822"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/cs\/wp-json\/wp\/v2\/media\/14815"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/cs\/wp-json\/wp\/v2\/media?parent=14811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/cs\/wp-json\/wp\/v2\/categories?post=14811"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/cs\/wp-json\/wp\/v2\/tags?post=14811"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/cs\/wp-json\/wp\/v2\/topics?post=14811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}