{"id":74961,"date":"2022-08-03T09:46:08","date_gmt":"2022-08-03T07:46:08","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=74961"},"modified":"2023-11-12T18:07:34","modified_gmt":"2023-11-12T17:07:34","slug":"compass-pathways-dava-zelenou-zkousce-psilocybinu-na-anorexii","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/cs\/blog\/compass-pathways-greenlights-psilocybin-trial-for-anorexia\/","title":{"rendered":"Compass Pathways d\u00e1v\u00e1 zelenou zkou\u0161ce psilocybinu na anorexii"},"content":{"rendered":"

Tento m\u011bs\u00edc Cesty COMPASS<\/a><\/strong> zah\u00e1jila klinickou studii f\u00e1ze II pro l\u00e9\u010dbu ment\u00e1ln\u00ed anorexie<\/a><\/strong>. Jejich zbra\u0148? Speci\u00e1ln\u00ed syntetick\u00e1 sm\u011bs \u00fa\u010dinn\u00e9 l\u00e1tky z magick\u00fdch hub a lan\u00fd\u017e\u016f, tzv. COMP360 psilocybin.<\/em><\/p>\n\n\n\n

Poj\u010fme se pod\u00edvat na tento nov\u00fd miln\u00edk v p\u0159\u00edprav\u011b, ano?<\/p>\n\n\n\n

Nov\u00e1 studie psilocybinu pro l\u00e9\u010dbu anorexie<\/strong><\/h2>\n\n\n\n

Nadch\u00e1zej\u00edc\u00ed studii po\u0159\u00e1daj\u00ed \u010dty\u0159i hork\u00e1 m\u00edsta psychedelick\u00e9ho v\u00fdzkumu. Konkr\u00e9tn\u011b King's College London, Columbia University, University of California San Diego a Sheppard Pratt. C\u00edlem je prozkoumat \u00fa\u010dinnost psilocybinu COMP360. (spolu s terapi\u00ed mluven\u00edm)<\/em> p\u0159i l\u00e9\u010db\u011b lid\u00ed s ment\u00e1ln\u00ed anorexi\u00ed.<\/p>\n\n\n\n

Tento \"multicentrick\u00e1, dvojit\u011b zaslepen\u00e1, randomizovan\u00e1 kontrola\"<\/em> je dal\u0161\u00edm v\u00fdznamn\u00fdm po\u010dinem spole\u010dnosti COMPASS Pathways po jejich pokro\u010dil\u00e9m v\u00fdzkumu. psilocybinov\u00e1 studie pro l\u00e9\u010dbu deprese<\/a><\/strong>. <\/p>\n\n\n\n

\"magick\u00e9
Foto p\u0159es Wholecelium<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

V\u00fdznam nov\u00e9 studie v\u0161ak spo\u010d\u00edv\u00e1 v tom, \u017ee v sou\u010dasn\u00e9 dob\u011b neexistuje \u017e\u00e1dn\u00e1 schv\u00e1len\u00e1 farmakologick\u00e1 l\u00e9\u010dba anorexie. Je t\u011b\u017ek\u00e9 tomu uv\u011b\u0159it. Stane se medic\u00edna na b\u00e1zi psilocybinu dlouho o\u010dek\u00e1vanou spolehlivou l\u00e9\u010debnou metodou? <\/p>\n\n\n\n

Dr. Guy Goodwin, vedouc\u00ed l\u00e9ka\u0159 spole\u010dnosti COMPASS Pathways, uvedl v tiskov\u00e9 zpr\u00e1v\u011b:<\/p>\n\n\n\n

\"Pro lidi s ment\u00e1ln\u00ed anorexi\u00ed neexistuje \u017e\u00e1dn\u00e1 schv\u00e1len\u00e1 farmakologick\u00e1 l\u00e9\u010dba a my jsme odhodl\u00e1ni to zm\u011bnit.<\/em><\/p>\n\n\n\n

\"Prov\u00e1d\u00edme tuto p\u0159\u00edsnou klinickou studii, abychom zjistili, zda by psilocybin COMP360 s psychologickou podporou mohl pomoci lidem trp\u00edc\u00edm ment\u00e1ln\u00ed anorexi\u00ed, kte\u0159\u00ed nal\u00e9hav\u011b pot\u0159ebuj\u00ed nov\u00e9 mo\u017enosti.\"<\/em><\/p>\n\n\n\n

COMP360 Psilocybinov\u00e1 terapie<\/strong><\/h2>\n\n\n\n

P\u0159ipravovan\u00e1 studie psilocybinu pro l\u00e9\u010dbu anorexie bude prvn\u00ed, kter\u00e1 bude vyu\u017e\u00edvat vlastn\u00ed aplikaci tzv. myPathfinder<\/a><\/em><\/strong>. Digit\u00e1ln\u00ed aplikace, kterou navrhla spole\u010dnost COMPASS, pom\u016f\u017ee \u00fa\u010dastn\u00edk\u016fm proj\u00edt terapi\u00ed psilocybinem COMP360. MyPathfinder<\/em> usnadn\u00ed cel\u00fd proces t\u00edm, \u017ee shrom\u00e1\u017ed\u00ed \u00fadaje o pacientech v re\u00e1ln\u00e9m sv\u011bt\u011b - samoz\u0159ejm\u011b s jejich souhlasem. Pacienti tak maj\u00ed mo\u017enost se do aplikace p\u0159ihl\u00e1sit nebo se z n\u00ed odhl\u00e1sit.<\/p>\n\n\n\n

\"\"
p\u0159es COMP360<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Jak p\u0159esn\u011b bude studie fungovat?<\/strong><\/p>\n\n\n\n

Nejprve v\u011bdci ze \u010dty\u0159 v\u00fdzkumn\u00fdch center ve Velk\u00e9 Brit\u00e1nii a USA vyberou 60 \u00fa\u010dastn\u00edk\u016f, kte\u0159\u00ed spl\u0148uj\u00ed krit\u00e9ria ment\u00e1ln\u00ed anorexie. Pacienti pak budou sezn\u00e1meni s celkov\u00fdm procesem, kter\u00fd porovn\u00e1v\u00e1 \u00fa\u010dinky 25 mg<\/strong> a 1 mg<\/strong> psilocybinu COMP360, pokud je pod\u00e1v\u00e1n spolu s terapi\u00ed rozhovorem.<\/p>\n\n\n\n

Pot\u00e9, pokud se u pacient\u016f projev\u00ed n\u011bjak\u00e9 zm\u011bny v p\u0159\u00edznac\u00edch anorexie. Ty budou m\u011b\u0159eny pomoc\u00ed testu tzv. Vy\u0161et\u0159en\u00ed poruch p\u0159\u00edjmu potravy (EDE) <\/strong>rozhovor. K\u00fd\u017een\u00fd c\u00edl? Aby terapie psilocybinem vyvolala zm\u011bnu glob\u00e1ln\u00edho sk\u00f3re EDE co nejd\u0159\u00edve. \u010dty\u0159i t\u00fddny.<\/em><\/p>\n\n\n\n

Nez\u016fstal k\u00e1men na kameni<\/strong>urned<\/h2>\n\n\n\n

Aby mohli b\u00fdt \u00fa\u010dastn\u00edci za\u0159azeni, mus\u00ed spl\u0148ovat krit\u00e9ria bu\u010f pro omezuj\u00edc\u00ed<\/strong> (\"bez j\u00eddla\")<\/em> nebo binge-purge<\/strong> (\"j\u00edst a pak zvracet\") <\/em>podtypy ment\u00e1ln\u00ed anorexie (m\u00edrn\u00e9 a\u017e t\u011b\u017ek\u00e9). Pacienti mus\u00ed m\u00edt tak\u00e9 alespo\u0148 t\u0159i roky trvaj\u00edc\u00ed poruchu p\u0159\u00edjmu potravy. a <\/em>se v posledn\u00edch t\u0159ech letech tak\u00e9 pokusili o l\u00e9\u010dbu.<\/p>\n\n\n\n

\"odraz
Foto: Rishabh Dharmani on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

\u00da\u010dastn\u00edci budou n\u00e1hodn\u011b rozd\u011bleni do skupin v pom\u011bru 2:1. To znamen\u00e1, \u017ee \u010dty\u0159icet osob obdr\u017e\u00ed jednu 25 mg d\u00e1vka psilocybinu<\/strong>, zat\u00edmco zb\u00fdvaj\u00edc\u00edch dvacet obdr\u017e\u00ed D\u00e1vka 1 mg<\/strong>. V\u0161ichni pacienti budou pravideln\u011b sledov\u00e1ni po dobu 12 t\u00fddn\u016f - zm\u011bny p\u0159\u00edznak\u016f anorexie se o\u010dek\u00e1vaj\u00ed p\u0159ibli\u017en\u011b ve 4. t\u00fddnu.<\/p>\n\n\n\n

B\u011bhem 12 t\u00fddn\u016f budou v\u011bdci m\u011b\u0159it zm\u011bny v pacientov\u011b chov\u00e1n\u00ed. psychologick\u00fd <\/em>p\u0159\u00edznaky pomoc\u00ed rozhovor\u016f a dotazn\u00edk\u016f, kter\u00e9 si sami vyplnili. Zm\u011bny v fyzick\u00fd<\/em> p\u0159\u00edznak\u016f bude provedeno m\u011b\u0159en\u00edm jejich hmotnosti. Budou tak\u00e9 provedeny bezpe\u010dnostn\u00ed kontroly, aby se sledovaly p\u0159\u00edznaky sebevra\u017eedn\u00fdch my\u0161lenek.<\/p>\n\n\n\n

Pravda o anorexii<\/strong><\/h2>\n\n\n\n

Ment\u00e1ln\u00ed anorexie je zni\u010duj\u00edc\u00ed onemocn\u011bn\u00ed, kter\u00e9 bylo po ur\u010ditou dobu m\u00e9dii podce\u0148ov\u00e1no.<\/p>\n\n\n\n

Jedn\u00e1 se o z\u00e1va\u017en\u00e9 du\u0161evn\u00ed onemocn\u011bn\u00ed, kter\u00e9 v\u00e1\u017en\u011b<\/em> omezuje p\u0159\u00edjem kalori\u00ed. V\u011bt\u0161ina z n\u00e1s m\u00e1 samoz\u0159ejm\u011b vlastn\u00ed nejistotu ohledn\u011b v\u00e1hy a postavy. Ment\u00e1ln\u00ed anorexie v\u0161ak jde je\u0161t\u011b o krok d\u00e1l, proto\u017ee jde o posedlost, kter\u00e1 ni\u010d\u00ed \u017eivot.<\/p>\n\n\n\n

O z\u00e1va\u017enosti anorexie sv\u011bd\u010d\u00ed i to, \u017ee v sou\u010dasn\u00e9 dob\u011b nem\u00e1 schv\u00e1lenou \u017e\u00e1dnou farmakologickou l\u00e9\u010dbu. (Jen pro srovn\u00e1n\u00ed: i u t\u011b\u017ek\u00e9 deprese jsou SSRI jednou z mo\u017enost\u00ed l\u00e9\u010dby!) <\/em>Anorexie m\u00e1 tak\u00e9 nejvy\u0161\u0161\u00ed \u00famrtnost<\/a><\/strong> v\u0161ech psychick\u00fdch poruch, kter\u00e9 jsou zp\u016fsobeny jak fyzick\u00fdmi, tak psychick\u00fdmi faktory.<\/p>\n\n\n\n

Na cel\u00e9m sv\u011bt\u011b se s ment\u00e1ln\u00ed anorexi\u00ed alespo\u0148 jednou v \u017eivot\u011b pot\u00fdk\u00e1 zhruba 2,2% \u017een a 0,3% mu\u017e\u016f. Kdy\u017e m\u00e1 \u010dlov\u011bk dlouhodob\u00e9 p\u0159\u00edznaky anorexie, za\u010dne se u n\u011bj objevovat \u0159ada z\u00e1va\u017en\u00fdch t\u011blesn\u00fdch probl\u00e9m\u016f, jako nap\u0159:<\/p>\n\n\n\n