{"id":268752,"date":"2026-03-08T09:13:11","date_gmt":"2026-03-08T08:13:11","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=268752"},"modified":"2026-03-08T09:13:12","modified_gmt":"2026-03-08T08:13:12","slug":"psilocybin-and-lyme-disease-new-research-explores-the-potential-of-magic-mushrooms","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/es\/blog\/psilocybin-and-lyme-disease-new-research-explores-the-potential-of-magic-mushrooms\/","title":{"rendered":"Psilocybin and Lyme Disease: New Research Explores the Potential of Magic Mushrooms"},"content":{"rendered":"<p style=\"font-size:20px\">Scientists continue to explore the therapeutic possibilities of <strong>psilocibina<\/strong>, the psychoactive compound found in <strong>hongos m\u00e1gicos<\/strong>, and a <a href=\"https:\/\/www.nature.com\/articles\/s41598-026-38091-9\" target=\"_blank\" rel=\"noreferrer noopener\">nuevo estudio<\/a> suggests it may hold promise for people living with <strong>post-treatment Lyme disease (PTLD)<\/strong>.<\/p>\n\n\n\n<p>Researchers at <strong>Universidad Johns Hopkins<\/strong> recently published a pilot study in <em>Informes cient\u00edficos<\/em> examining whether psilocybin-assisted therapy could help alleviate the persistent symptoms many patients experience after standard Lyme disease treatment.<\/p>\n\n\n\n<p>The early results point to meaningful improvements in symptoms and quality of life lasting up to six months after treatment. While the study was small and exploratory, the findings have generated interest in the potential role psychedelics may play in addressing conditions that currently have few treatment options.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"377\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/lyme-disease-tick-hand.jpg\" alt=\"\" class=\"wp-image-268770\" style=\"width:800px;height:auto\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/lyme-disease-tick-hand.jpg 640w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/lyme-disease-tick-hand-300x177.jpg 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/lyme-disease-tick-hand-18x12.jpg 18w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/lyme-disease-tick-hand-600x353.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">Foto de Marino Linic en Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Understanding Lyme Disease<\/h2>\n\n\n\n<p><strong>To appreciate why this research matters, it helps to understand what Lyme disease is and how it can affect the body.<\/strong><\/p>\n\n\n\n<p><strong>Lyme disease<\/strong> is an infectious illness caused by the bacterium <em>Borrelia burgdorferi<\/em>. The bacteria are transmitted to humans through the bite of infected ticks, most commonly black-legged ticks <em>(often called deer ticks)<\/em>. Lyme disease is the most widespread <strong>vector-borne disease<\/strong> in both the United States and Europe.<\/p>\n\n\n\n<p>Early symptoms can resemble the flu and may include fever, fatigue, muscle aches, headache, and swollen lymph nodes. One of the most recognizable signs is a distinctive \u201cbull\u2019s-eye\u201d rash called <strong>erythema migrans<\/strong>, although not everyone develops it.<\/p>\n\n\n\n<p>If diagnosed early, Lyme disease is usually treated successfully with antibiotics. However, the infection can affect multiple systems in the body. In some cases it spreads to joints, the nervous system, or the heart. Neurological involvement may lead to problems such as memory difficulties, headaches, or nerve pain.<\/p>\n\n\n\n<p>For many patients, antibiotic therapy resolves the infection and symptoms fade. Yet an estimated <strong>10\u201320% of people continue to experience health problems even after treatment<\/strong>. This condition is known as <strong>post-treatment Lyme disease (PTLD)<\/strong>.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"640\" height=\"349\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/disease-scan.jpg\" alt=\"\" class=\"wp-image-268771\" style=\"width:800px;height:auto\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/disease-scan.jpg 640w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/disease-scan-300x164.jpg 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/disease-scan-18x10.jpg 18w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/disease-scan-600x327.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">Photo by National Institute of Allergy and Infectious Diseases on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">What Is Post-Treatment Lyme Disease?<\/h3>\n\n\n\n<p>People living with PTLD report a range of ongoing symptoms that can persist for months or years. These often include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Persistent fatigue<\/li>\n\n\n\n<li>Joint or muscle pain<\/li>\n\n\n\n<li>Cognitive difficulties sometimes described as \u201cbrain fog\u201d<\/li>\n\n\n\n<li>Sleep disturbances<\/li>\n\n\n\n<li>Mood changes such as anxiety or depression<\/li>\n\n\n\n<li>Reduced overall quality of life<\/li>\n<\/ul>\n\n\n\n<p>Researchers are still working to understand why PTLD occurs. Some theories suggest lingering immune system dysregulation or inflammation following infection. Others point to long-term neurological effects.<\/p>\n\n\n\n<p>At present, <strong>there are no widely accepted treatments specifically for PTLD<\/strong>, which leaves many patients searching for ways to manage symptoms.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Investigating Psilocybin as a Potential Therapy<\/h4>\n\n\n\n<p>The new study from Johns Hopkins explored whether <strong>psilocybin-assisted therapy<\/strong> might help improve well-being in people living with PTLD.<\/p>\n\n\n\n<p>Psilocybin occurs naturally in several species of <strong>psychoactive mushrooms<\/strong>, often referred to as <strong>hongos m\u00e1gicos<\/strong>. Once consumed, the compound is converted in the body to psilocin, which interacts with serotonin receptors in the brain.<\/p>\n\n\n\n<p>Over the past decade, psilocybin has been widely studied for its possible benefits in areas such as depression, addiction, anxiety, and emotional distress related to serious illness.<\/p>\n\n\n\n<p>The researchers wanted to see whether the compound, when combined with psychological support, could also help patients experiencing long-term symptoms associated with Lyme disease.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"639\" height=\"404\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/mushroom-gills-medicinal-2.jpg\" alt=\"\" class=\"wp-image-268772\" style=\"width:800px;height:auto\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/mushroom-gills-medicinal-2.jpg 639w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/mushroom-gills-medicinal-2-300x190.jpg 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/mushroom-gills-medicinal-2-18x12.jpg 18w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/mushroom-gills-medicinal-2-600x379.jpg 600w\" sizes=\"(max-width: 639px) 100vw, 639px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">Inside the Study<\/h3>\n\n\n\n<p>The pilot trial involved <strong>20 participants diagnosed with PTLD<\/strong>. Over the course of an eight-week intervention period, they received <strong>two low-to-moderate doses of psilocybin<\/strong> along with structured psychological support.<\/p>\n\n\n\n<p>Before their first dosing session, participants attended <strong>standardised psychoeducation meetings<\/strong> where they learned about the effects of psilocybin and discussed what they might experience during sessions.<\/p>\n\n\n\n<p>They also completed a <strong>life review process<\/strong>, reflecting on their personal history with Lyme disease as well as other significant life events \u2014 including trauma, relationships, and work experiences \u2014 that could influence their health.<\/p>\n\n\n\n<p>The study schedule included two psilocybin sessions:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Week 4:<\/strong> Participants received their first dose of 15 mg<\/li>\n\n\n\n<li><strong>Two weeks later:<\/strong> Most participants received a 25 mg dose, while some received another 15 mg depending on tolerance<\/li>\n<\/ul>\n\n\n\n<p><em>\u201cAfter each psilocybin session, participants completed a follow-up integration meeting within 3 days to assess their mental status and document any adverse events. Weekly meetings with facilitators were conducted through week 8 to discuss the contents of participants\u2019 psilocybin session and to monitor their overall progress,\u201d<\/em> the study author explains.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.wholecelium.com\/es\/blog\/por-que-nunca-debes-saltarte-la-integracion-psicodelica\/\" type=\"post\" id=\"158678\" target=\"_blank\" rel=\"noreferrer noopener\">Integration sessions<\/a> are commonly used in psychedelic-assisted therapy to help participants reflect on their experiences and incorporate insights into daily life.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"331\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/therapy-lyme-man.jpg\" alt=\"\" class=\"wp-image-268773\" style=\"width:800px;height:auto\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/therapy-lyme-man.jpg 640w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/therapy-lyme-man-300x155.jpg 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/therapy-lyme-man-18x9.jpg 18w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/therapy-lyme-man-600x310.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">Foto de Kelly Sikkema en Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">Improvements in Symptoms and Quality of Life<\/h4>\n\n\n\n<p>By the end of the study period and during follow-up assessments, researchers observed notable improvements across several measures.<\/p>\n\n\n\n<p>Participants reported <strong>reduced overall symptom burden and improved quality of life<\/strong>, with benefits persisting for up to six months after the final dose.<\/p>\n\n\n\n<p>At the six-month mark, the study recorded a <strong>40% reduction in symptom burden<\/strong> compared with baseline.<\/p>\n\n\n\n<p>Both mental and physical quality-of-life scores increased by approximately <strong>13%<\/strong>, while measures related to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>depresi\u00f3n<\/li>\n\n\n\n<li>fatiga<\/li>\n\n\n\n<li>sleep disturbances<\/li>\n\n\n\n<li>pain<\/li>\n<\/ul>\n\n\n\n<p>also showed meaningful improvement.<\/p>\n\n\n\n<p>These changes remained better than baseline levels during all follow-up assessments at one, three, and six months after treatment.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"355\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/man-looking-at-view-optimism.jpg\" alt=\"\" class=\"wp-image-268774\" style=\"width:800px;height:auto\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/man-looking-at-view-optimism.jpg 640w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/man-looking-at-view-optimism-300x166.jpg 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/man-looking-at-view-optimism-18x10.jpg 18w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/man-looking-at-view-optimism-600x333.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">Photo by Tamas Pap on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<h5 class=\"wp-block-heading\">Safety and Side Effects<\/h5>\n\n\n\n<p>The treatment protocol was reported to be <strong>safe and well-tolerated<\/strong> among participants.<\/p>\n\n\n\n<p>No serious adverse events occurred during the trial. The most frequently reported side effects were temporary and included:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>elevated blood pressure<\/li>\n\n\n\n<li>headaches<\/li>\n\n\n\n<li>increased heart rate<\/li>\n<\/ul>\n\n\n\n<p>These effects occurred during or shortly after psilocybin sessions and resolved without long-term complications.<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">What the Researchers Concluded<\/h6>\n\n\n\n<p>Because the trial involved a relatively small group and lacked a placebo control, the results are considered preliminary. Larger, randomized clinical trials will be needed to determine whether psilocybin therapy can reliably help patients with PTLD.<\/p>\n\n\n\n<p>Still, the researchers see the results as encouraging.<\/p>\n\n\n\n<p>They concluded that the findings were <strong><em>\u201csufficiently positive to encourage additional randomised controlled research with psilocybin in patients with PTLD\u201d.<\/em><\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">The Expanding Field of Psilocybin Research<\/h3>\n\n\n\n<p>Interest in <strong>terapia con psilocibina<\/strong> has grown rapidly in recent years. As our regular readers will know, clinical studies have examined its potential role in treating a variety of conditions, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.wholecelium.com\/es\/blog\/un-estudio-britanico-revela-que-las-setas-magicas-son-un-tratamiento-eficaz-contra-la-depresion\/\" type=\"post\" id=\"192371\" target=\"_blank\" rel=\"noreferrer noopener\">depresi\u00f3n mayor<\/a><\/li>\n\n\n\n<li>substance use disorders such as <a href=\"https:\/\/www.wholecelium.com\/es\/blog\/pueden-los-psicodelicos-sustituir-a-los-opiaceos-como-analgesicos-sin-adiccion\/\" type=\"post\" id=\"166313\" target=\"_blank\" rel=\"noreferrer noopener\">opioid addiction<\/a><\/li>\n\n\n\n<li>anxiety related to serious illness<\/li>\n\n\n\n<li>age-related <a href=\"https:\/\/www.wholecelium.com\/es\/blog\/los-psicodelicos-como-tratamiento-de-la-enfermedad-de-alzheimers\/\" type=\"post\" id=\"49521\" target=\"_blank\" rel=\"noreferrer noopener\">cognitive decline<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.wholecelium.com\/es\/blog\/can-psilocybin-reset-your-metabolism\/\" type=\"post\" id=\"262910\" target=\"_blank\" rel=\"noreferrer noopener\">metabolic conditions<\/a> such as fatty liver disease<\/li>\n<\/ul>\n\n\n\n<p>The new research adds <strong>post-treatment Lyme disease<\/strong> to the list of areas scientists are beginning to investigate.<\/p>\n\n\n\n<p>For individuals living with PTLD \u2014 a condition that can profoundly affect daily functioning \u2014 even early signs of potential relief offer a reason for cautious optimism.<\/p>\n\n\n\n<p>As larger studies move forward, researchers hope to better understand how <strong>psilocybin and magic mushroom compounds interact with the brain and immune system<\/strong>, and whether these effects could translate into new therapeutic options for chronic conditions that currently lack effective treatments.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"1000\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-29.png\" alt=\"\" class=\"wp-image-268775\" style=\"width:429px;height:auto\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-29.png 1000w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-29-300x300.png 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-29-150x150.png 150w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-29-768x768.png 768w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-29-12x12.png 12w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-29-600x600.png 600w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-29-100x100.png 100w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/figure>","protected":false},"excerpt":{"rendered":"<p>A new study explores whether psilocybin-assisted therapy could help treat the symptoms of Lyme disease that for some people continue long after traditional treatments. <\/p>","protected":false},"author":4,"featured_media":268777,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88,68],"tags":[],"topics":[],"class_list":["post-268752","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-studies","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/es\/wp-json\/wp\/v2\/posts\/268752","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/es\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/es\/wp-json\/wp\/v2\/comments?post=268752"}],"version-history":[{"count":3,"href":"https:\/\/www.wholecelium.com\/es\/wp-json\/wp\/v2\/posts\/268752\/revisions"}],"predecessor-version":[{"id":268946,"href":"https:\/\/www.wholecelium.com\/es\/wp-json\/wp\/v2\/posts\/268752\/revisions\/268946"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/es\/wp-json\/wp\/v2\/media\/268777"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/es\/wp-json\/wp\/v2\/media?parent=268752"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/es\/wp-json\/wp\/v2\/categories?post=268752"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/es\/wp-json\/wp\/v2\/tags?post=268752"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/es\/wp-json\/wp\/v2\/topics?post=268752"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}