{"id":74961,"date":"2022-08-03T09:46:08","date_gmt":"2022-08-03T07:46:08","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=74961"},"modified":"2023-11-12T18:07:34","modified_gmt":"2023-11-12T17:07:34","slug":"compass-pathways-annab-rohelise-tee-psilotsubiini-uuringule-anoreksia-raviks","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/et\/blog\/compass-pathways-greenlights-psilocybin-trial-for-anorexia\/","title":{"rendered":"Compass Pathways Greenlights Psilocybin Trial anoreksia jaoks"},"content":{"rendered":"<p>Sel kuul\u00a0<strong><a href=\"https:\/\/compasspathways.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">COMPASS Pathways<\/a><\/strong>\u00a0on alustanud II faasi kliinilist uuringut raviks\u00a0<strong><a href=\"https:\/\/www.nationaleatingdisorders.org\/learn\/by-eating-disorder\/anorexia\" target=\"_blank\" rel=\"noreferrer noopener\">anoreksia nervosa<\/a><\/strong>.\u00a0Their weapon of choice? A special synthetic blend of the active compound in magic mushrooms and truffles, called\u00a0<em>COMP360 psilots\u00fcbiin.<\/em><\/p>\n\n\n\n<p>Heidame pilgu sellele uuele verstapostile, mis on valmimas, kas poleks?<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-new-psilocybin-trial-for-anorexia\"><strong>Uus Psilots\u00fcbiini uuring anoreksia puhul<\/strong><\/h2>\n\n\n\n<p>Eelseisvat uuringut korraldavad neli ps\u00fchhedeelsete uuringute keskust. Nimelt King's College London, Columbia \u00dclikool, California San Diego \u00dclikool ja Sheppard Pratt. Eesm\u00e4rk on uurida COMP360 psiilots\u00fcbiini t\u00f5husust. <em>(along with\u00a0talk therapy)<\/em> anorexia nervosa'ga inimeste ravimisel.<\/p>\n\n\n\n<p>See\u00a0<em>\"mitmekeskuseline, topeltpime, randomiseeritud kontrollitud\"<\/em>\u00a0katse on COMPASS Pathways j\u00e4rgmine suurem j\u00f5upingutus p\u00e4rast nende arenenud\u00a0<strong><a href=\"https:\/\/compasspathways.com\/further-positive-results-phase-iib-trial\/\" target=\"_blank\" rel=\"noreferrer noopener\">psilots\u00fcbiini uuring depressiooni puhul<\/a><\/strong>.\u00a0<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"634\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/go-grow-kit-10-1024x634.jpeg\" alt=\"maagilised seened sinine taust\" class=\"wp-image-161735\" style=\"width:842px;height:465px\" title=\"\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/go-grow-kit-10-1024x634.jpeg 1024w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/go-grow-kit-10-300x186.jpeg 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/go-grow-kit-10-768x475.jpeg 768w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/go-grow-kit-10-18x12.jpeg 18w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/go-grow-kit-10-600x371.jpeg 600w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/go-grow-kit-10.jpeg 1181w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">Foto via Wholecelium<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<p>Uue uuringu teeb aga nii oluliseks asjaolu, et praegu ei ole anoreksia puhul \u00fchtegi heakskiidetud farmakoloogilist raviv\u00f5imalust. Seda on raske uskuda. Kas psiilots\u00fcbiinil p\u00f5hinevast ravimist saab kauaoodatud usaldusv\u00e4\u00e4rne ravimeetod? <\/p>\n\n\n\n<p>Dr. Guy Goodwin, COMPASS Pathways'i meditsiiniline juht, \u00fctles pressiteates:<\/p>\n\n\n\n<p><em>\"Anoreksia nervosa all kannatavatele inimestele ei ole heakskiidetud farmakoloogilisi raviv\u00f5imalusi ja me oleme otsustanud seda muuta.<\/em><\/p>\n\n\n\n<p><em>\"Me viime l\u00e4bi selle range kliinilise uuringu, et m\u00f5ista, kas COMP360 psilots\u00fcbiin koos ps\u00fchholoogilise toetusega v\u00f5iks aidata anoreksiat p\u00f5devaid inimesi, kes vajavad kiiresti uusi v\u00f5imalusi.\"<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>COMP360 Psilocybin teraapia<\/strong><\/h2>\n\n\n\n<p>Eelseisev psiilots\u00fcbiini uuring anoreksia puhul on esimene, kus kasutatakse kohandatud rakendust nimega\u00a0<strong><em><a href=\"https:\/\/compasspathways.com\/our-work\/digital-technologies\/\" target=\"_blank\" rel=\"noreferrer noopener\">myPathfinder<\/a><\/em><\/strong>.\u00a0The digital app, designed by COMPASS, will help guide participants as they go through their COMP360 psilocybin therapy.\u00a0<em>MyPathfinder<\/em>\u00a0teeb kogu protsessi arusaadavamaks, kogudes patsientide tegelikke andmeid - muidugi nende n\u00f5usolekul. Sellisena on patsientidel v\u00f5imalus rakendusega n\u00f5ustuda v\u00f5i sellest loobuda.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"500\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/myPathfinder-july-2-1024x500.png\" alt=\"\" class=\"wp-image-161738\" style=\"width:841px\" title=\"\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/myPathfinder-july-2-1024x500.png 1024w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/myPathfinder-july-2-300x146.png 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/myPathfinder-july-2-768x375.png 768w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/myPathfinder-july-2-1536x750.png 1536w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/myPathfinder-july-2-18x9.png 18w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/myPathfinder-july-2-600x293.png 600w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/myPathfinder-july-2.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">COMP360 kaudu<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<p><strong>Kuidas uuring t\u00e4pselt toimib?<\/strong><\/p>\n\n\n\n<p>K\u00f5igepealt valivad \u00dchendkuningriigi ja USA nelja uurimiskeskuse teadlased v\u00e4lja 60 osalejat, kes vastavad anoreksia nervosa kriteeriumidele. Seej\u00e4rel r\u00e4\u00e4gitakse patsientidele \u00fcldisest protsessist, milles v\u00f5rreldakse m\u00f5ju\u00a0<strong>25 mg<\/strong>\u00a0ja\u00a0<strong>1 mg<\/strong>\u00a0COMP360 psiilots\u00fcbiinist, kui seda antakse koos k\u00f5neraviga.<\/p>\n\n\n\n<p>P\u00e4rast seda, kui patsientide anoreksia s\u00fcmptomites ilmnevad muutused. Neid m\u00f5\u00f5detakse testiga, mida nimetatakse\u00a0<strong>S\u00f6\u00f6mish\u00e4irete uurimine (EDE)\u00a0<\/strong>intervjuu. Soovitud eesm\u00e4rk? Psiilots\u00fcbiinravi vallandada muutus EDE globaalses skooris niipea, kui\u00a0<em>neli n\u00e4dalat.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u00dckski kivi ei j\u00e4\u00e4 katmata<\/strong>urned<\/h2>\n\n\n\n<p>Selleks, et osalejad saaksid osaleda, peavad nad vastama kas j\u00e4rgmiste kriteeriumide tingimustele\u00a0<strong>piirav<\/strong>\u00a0<em>(\"no-eat\")<\/em>\u00a0v\u00f5i\u00a0<strong>binge-purge<\/strong>\u00a0<em>(\"s\u00f6\u00f6ge-kuulge-oksendage\")\u00a0<\/em>anorexia nervosa alat\u00fc\u00fcbid (kerge kuni raske). Patsientidel peab olema ka v\u00e4hemalt kolm aastat s\u00f6\u00f6mish\u00e4ireid.<em>\u00a0ja\u00a0<\/em>on viimase kolme aasta jooksul samuti ravi proovinud.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"636\" height=\"334\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/sky-reflection-in-mirror.jpg\" alt=\"taeva peegeldus peeglis\" class=\"wp-image-161739\" style=\"width:841px;height:501px\" title=\"\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/sky-reflection-in-mirror.jpg 636w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/sky-reflection-in-mirror-300x158.jpg 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/sky-reflection-in-mirror-18x9.jpg 18w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/sky-reflection-in-mirror-600x315.jpg 600w\" sizes=\"(max-width: 636px) 100vw, 636px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">Foto: Rishabh Dharmani on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<p>Osalejad grupeeritakse juhuslikult 2:1. See t\u00e4hendab, et nelik\u00fcmmend inimest saavad \u00fche\u00a0<strong>25 mg psilots\u00fcbiini annus<\/strong>, samas kui \u00fclej\u00e4\u00e4nud kaksk\u00fcmmend saavad\u00a0<strong>1 mg annus<\/strong>. K\u00f5iki patsiente j\u00e4lgitakse regulaarselt 12 n\u00e4dala jooksul, kusjuures muutusi anoreksia s\u00fcmptomites oodatakse umbes 4. n\u00e4dalal.<\/p>\n\n\n\n<p>12-n\u00e4dalase perioodi jooksul m\u00f5\u00f5davad teadlased k\u00f5iki muutusi patsientide\u00a0<em>ps\u00fchholoogiline\u00a0<\/em>s\u00fcmptomid, kasutades intervjuusid ja eneseraporteeritud k\u00fcsimustikke. Muutused\u00a0<em>f\u00fc\u00fcsiline<\/em>\u00a0s\u00fcmptomid toimuvad nende kaalu m\u00f5\u00f5tmise teel. Samuti viiakse l\u00e4bi turvakontrollid, et j\u00e4lgida enesetapum\u00f5tete varjatuid m\u00e4rke.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>T\u00f5de anoreksia kohta<\/strong><\/h2>\n\n\n\n<p>Anorexia nervosa on laastav seisund, mida meedia m\u00f5nda aega alahindas.<\/p>\n\n\n\n<p>See on t\u00f5sine vaimuhaigus, mis\u00a0<em>t\u00f5siselt<\/em>\u00a0piirab teie kaloraa\u017ei. Enamikul meist on muidugi oma ebakindlus kehakaalu ja kehakuju suhtes. Anoreksia nervosa l\u00e4heb aga sammu v\u00f5rra kaugemale kui elu h\u00e4vitav kinnisidee.<\/p>\n\n\n\n<p>T\u00f5endina selle t\u00f5sidusest ei ole anoreksial praegu \u00fchtegi heakskiidetud farmakoloogilist ravi.<em>\u00a0(V\u00f5rdluseks: isegi raske depressioonil on raviv\u00f5imalusena olemas SSRI-d!)\u00a0<\/em>Anoreksia on ka\u00a0<strong><a href=\"https:\/\/www.eatingdisorderhope.com\/information\/anorexia\/anorexia-death-rate\" target=\"_blank\" rel=\"noreferrer noopener\">k\u00f5rgeim suremus<\/a><\/strong>\u00a0k\u00f5ikidest ps\u00fchholoogilistest h\u00e4iretest, mis on tingitud nii f\u00fc\u00fcsilistest kui ka vaimsetest teguritest.<\/p>\n\n\n\n<p>Kogu maailmas v\u00f5itlevad umbes 2,2% naistest ja 0,3% meestest v\u00e4hemalt korra elus anoreksia nervosa'ga. Kui inimesel on pikaajalised anoreksia s\u00fcmptomid, hakkavad tal tekkima mitmed t\u00f5sised f\u00fc\u00fcsilised probleemid, n\u00e4iteks<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Komplikatsioonid lihaste ja luudega, n\u00e4iteks osteoporoos;<\/li>\n\n\n\n<li>ajukahjustus, mis p\u00f5hjustab m\u00e4lukaotust ja krampe; ja<\/li>\n\n\n\n<li>S\u00fcdameprobleemid, mis sageli p\u00f5hjustavad s\u00fcdamepuudulikkust.<\/li>\n<\/ul>\n\n\n\n<p>Samal ajal halveneb ka patsiendi vaimne seisund. See suurendab enesetapu t\u00f5en\u00e4osust - 20-40% surmajuhtumi otsene p\u00f5hjus anoreksia nervosa korral.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Psilots\u00fcbiin anoreksia raviks<\/strong><\/h2>\n\n\n\n<p>Dr. Walter Kaye, uuringu juhtivteadur ja California \u00dclikooli meditsiinikooli ps\u00fchhiaatriaprofessor - ps\u00fchhiaatria osakond, s\u00f6\u00f6mish\u00e4irete programm, \u00fctles pressiteates:<\/p>\n\n\n\n<p><em>\"Anoreksia nervosa on \u00fcks k\u00f5ige raskemini ravitavatest seisunditest, millega me ps\u00fchhiaatrias silmitsi seisame, ja selle puhul on enesetappude m\u00e4\u00e4r k\u00f5ige k\u00f5rgem kui muude vaimse tervise probleemide puhul. See v\u00f5ib avaldada suurt m\u00f5ju mitte ainult selle all kannatavatele inimestele, vaid ka nende l\u00e4hedastele.<\/em><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"640\" height=\"325\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/hand-drowing-in-ocean-depression-1.jpg\" alt=\"uppumine mere k\u00e4es\" class=\"wp-image-161740\" style=\"width:841px;height:520px\" title=\"\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/hand-drowing-in-ocean-depression-1.jpg 640w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/hand-drowing-in-ocean-depression-1-300x152.jpg 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/hand-drowing-in-ocean-depression-1-18x9.jpg 18w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/hand-drowing-in-ocean-depression-1-600x305.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">Foto Unsplashi kaudu<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<p><em>\"Uuringud ja edusammud on h\u00e4dasti vajalikud; me oleme juba n\u00e4inud julgustavaid andmeid uurimuslikust, avatud uuringust, mis viidi l\u00e4bi\u00a0<\/em><strong><em>anoreksia nervosa ravimine COMP360 psilots\u00fcbiinravi abil<\/em><\/strong><em>ja see II faasi uuring on j\u00e4rjekordne oluline samm edasi.\"<\/em><\/p>\n\n\n\n<p>COMPASS Pathways'i hiljutine aktsiabuum on alates maist enam kui kahekordistunud. On selge, et investorite maailm p\u00f6\u00f6rab sellele suurt t\u00e4helepanu. See t\u00e4hendab \u00fcht: kliiniliste uuringute kiire k\u00e4ivitamine psiilots\u00fcbiinil p\u00f5hineva ravimi arendamiseks, mis j\u00f5uab peagi peavoolu.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Lootus anoreksiaga patsientidele<\/strong><\/h2>\n\n\n\n<p>Esialgne\u00a0<strong><a href=\"https:\/\/compasspathways.com\/comp360-psilocybin-therapy-shows-potential-in-exploratory-open-label-studies-for-anorexia-nervosa-and-severe-treatment-resistant-depression\/\" target=\"_blank\" rel=\"noreferrer noopener\">uuring<\/a><\/strong>\u00a0mida dr Kaye mainis, avaldati eelmise aasta mais ja n\u00e4itas paljut\u00f5otavaid tulemusi psiilots\u00fcbiini kasutamisel anoreksia nervosa raviks. Avatud uuringuid saab siiski vaevalt liigitada\u00a0<em>\"l\u00f5plikud t\u00f5endid\"<\/em>\u00a0for making psilocybin-based medicine \u2014 at least in the eyes of the law and investors. \u00a0Hence the current plan for a proper clinical trial overseen by experts from four centres in the US and the UK.<\/p>\n\n\n\n<p>Kas psilots\u00fcbiin, mis on toimeaine maagilistes seentes ja tr\u00fchvlites, v\u00f5ib l\u00f5puks anda anoreksia nervosa all kannatavatele inimestele t\u00f5husa liitlase nende taastumisel? T\u00f5endid n\u00e4ivad olevat kindlad, nii et j\u00e4lgige seda ruumi.<\/p>\n\n\n\n<p><em>P\u00f6idlad ristis, t\u00f5epoolest!<\/em><\/p>","protected":false},"excerpt":{"rendered":"<p>Breaking ps\u00fchhedeelne uudis! P\u00e4rast eelmise aasta FDA heakskiitu Tryp Therapeutics'i 2a faasi uuringule, milles kasutati psilots\u00fcbiini s\u00f6\u00f6mish\u00e4ire raviks, on teine ettev\u00f5te j\u00f5udmas sarnase eesm\u00e4rgi saavutamiseni.<\/p>","protected":false},"author":4,"featured_media":75387,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"topics":[],"class_list":["post-74961","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-wholecelium"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/et\/wp-json\/wp\/v2\/posts\/74961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/et\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/et\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/et\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/et\/wp-json\/wp\/v2\/comments?post=74961"}],"version-history":[{"count":2,"href":"https:\/\/www.wholecelium.com\/et\/wp-json\/wp\/v2\/posts\/74961\/revisions"}],"predecessor-version":[{"id":161741,"href":"https:\/\/www.wholecelium.com\/et\/wp-json\/wp\/v2\/posts\/74961\/revisions\/161741"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/et\/wp-json\/wp\/v2\/media\/75387"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/et\/wp-json\/wp\/v2\/media?parent=74961"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/et\/wp-json\/wp\/v2\/categories?post=74961"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/et\/wp-json\/wp\/v2\/tags?post=74961"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/et\/wp-json\/wp\/v2\/topics?post=74961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}