{"id":188827,"date":"2024-04-22T16:50:12","date_gmt":"2024-04-22T14:50:12","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=188827"},"modified":"2024-04-22T16:50:24","modified_gmt":"2024-04-22T14:50:24","slug":"tyrimas-parode-kad-psilocibinas-gali-buti-veiksmingas-cukrinio-diabeto-gydymo-budas","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/lt\/blog\/study-finds-psilocybin-may-be-an-effective-treatment-for-diabetes\/","title":{"rendered":"Tyrimas parod\u0117, kad psilocibinas gali b\u016bti veiksmingas cukrinio diabeto gydymo b\u016bdas"},"content":{"rendered":"<p style=\"font-size:21px\"><strong>Pastaraisiais metais, <a href=\"https:\/\/www.wholecelium.com\/lt\/wiki\/mikologija\/what-is-psilocybin\/\" target=\"_blank\" rel=\"noreferrer noopener\">psilocibinas<\/a> <em>(psichoaktyvus junginys magi\u0161kuosiuose grybuose ir triufeliuose) <\/em>prad\u0117ta pripa\u017einti jo terapin\u012f potencial\u0105, ypa\u010d gydant psichikos sveikatos sutrikimus. Rezultatai tokie daug \u017eadantys, kad dabar ji netgi tiriama gydant <a href=\"https:\/\/www.wholecelium.com\/lt\/tinklarastis\/ar-magiskieji-grybai-gali-gydyti-fizini-skausma\/\" target=\"_blank\" rel=\"noreferrer noopener\">fizinis skausmas<\/a>, ir pasiek\u0117 s\u0117kming\u0173 rezultat\u0173. Kadangi tiek daug jo veikimo mechanizm\u0173 vis dar yra paslaptis, nenuostabu, kad vis\u0173 sri\u010di\u0173 mokslininkai nori i\u0161tirti tolesn\u012f psilocibino panaudojim\u0105.<\/strong><\/p>\n\n\n\n<p>Tai atsispindi <a href=\"https:\/\/www.mdpi.com\/2073-4425\/15\/2\/183\" target=\"_blank\" rel=\"noreferrer noopener\">\u012fdomus naujas tyrimas<\/a>, paskelbta \u017eurnale <em>Genai<\/em>, kuriame nagrin\u0117jamas psilocibino kaip diabeto gydymo b\u016bdo perspektyvumas. Tyrimo autorius Igoris Koval\u010diukas paai\u0161kino;<\/p>\n\n\n\n<p><em>\"Diabetas ir metabolinis sindromas vargina visuomen\u0119, tod\u0117l ie\u0161kojome \u012fvairi\u0173 b\u016bd\u0173, kaip prisid\u0117ti prie kovos su \u0161iomis ligomis... Kadangi mikrodozavimas grybais gali tapti vienu i\u0161 \u012fvairi\u0173 lig\u0173 gydymo b\u016bd\u0173, nor\u0117jome patikrinti, ar j\u0173 veiklioji med\u017eiaga psilocibinas taip pat tur\u0117t\u0173 antidiabetin\u012f poveik\u012f.\"<\/em><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"640\" height=\"360\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/mushrooms-growing-9.jpg\" alt=\"\" class=\"wp-image-188829\" style=\"width:840px;height:auto\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/mushrooms-growing-9.jpg 640w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/mushrooms-growing-9-300x169.jpg 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/mushrooms-growing-9-18x10.jpg 18w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/mushrooms-growing-9-600x338.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">per Creative Commons<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-psilocybin-the-serotonin-whisperer\">Psilocibinas: Serotonino u\u017ekalb\u0117tojas<\/h2>\n\n\n\n<p>Ir tai tikrai n\u0117ra tik psichodelinis \u0161okin\u0117jimas per bangas. Psilocibinas s\u0105veikauja su smegenyse esan\u010diais serotonino receptoriais, o tai yra vienas i\u0161 daugelio b\u016bd\u0173, kaip jis <a href=\"https:\/\/www.wholecelium.com\/lt\/tinklarastis\/psilocibinas-kaip-parode-didziausias-iki-siol-atliktas-tyrimas-palengvina-depresija\/\" target=\"_blank\" rel=\"noreferrer noopener\">veiksminga kaip psichikos sveikatos gydymo priemon\u0117.<\/a>. Ta\u010diau ar \u017einojote, kad serotonino receptori\u0173 yra ir kasoje, kurioje gaminamas insulinas? Gaminant insulin\u0105 <em>(arba j\u0173 nebuvimas) <\/em>Kadangi psilocibinas yra pagrindin\u0117 diabeto prie\u017eastis, ar unikalus psilocibino \u012fg\u016bd\u017ei\u0173 rinkinys gali pakeisti \u017eaidim\u0105?<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-what-causes-diabetes\">Kas sukelia diabet\u0105? <\/h3>\n\n\n\n<p>Diabetas yra l\u0117tinis med\u017eiag\u0173 apykaitos sutrikimas, kuris pasirei\u0161kia, kai kasa nustoja gaminti insulin\u0105 arba organizmas nebegali efektyviai naudoti gaminamo insulino. Insulinas yra hormonas, kuris i\u0161 suvalgyto maisto gaunam\u0105 gliukoz\u0119 paver\u010dia energija, kuri\u0105 gali panaudoti m\u016bs\u0173 l\u0105stel\u0117s. Kai m\u016bs\u0173 organizmas negali veiksmingai gaminti ar naudoti insulino, kraujyje atsiranda didelis gliukoz\u0117s kiekis, kuris vadinamas <em>hiperglikemija. <\/em>Ilgainiui toks didelis gliukoz\u0117s kiekis kraujyje gali pakenkti organizmui ir sukelti \u012fvairi\u0173 organ\u0173 ir audini\u0173 nepakankamum\u0105. Taigi, pasak tyrimo autori\u0173, psilocibinas, s\u0105veikaudamas su kasos serotonino l\u0105stel\u0117mis, gali u\u017ekirsti keli\u0105 gyvybi\u0161kai svarbi\u0173 insulin\u0105 gaminan\u010di\u0173 l\u0105steli\u0173 praradimui.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"640\" height=\"427\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/diabetes-shot.jpg\" alt=\"\" class=\"wp-image-188831\" style=\"width:840px;height:auto\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/diabetes-shot.jpg 640w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/diabetes-shot-300x200.jpg 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/diabetes-shot-18x12.jpg 18w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/diabetes-shot-600x400.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">Matt C nuotrauka Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-how-the-study-worked\">Kaip vyko tyrimas<\/h4>\n\n\n\n<p>Tyrimo metu mokslininkai tyr\u0117 psilocibino poveik\u012f kasos \u03b2 l\u0105stel\u0117ms. Kasos \u03b2 l\u0105stel\u0117s yra l\u0105stel\u0117s, atsakingos u\u017e insulino gamyb\u0105. Kai jos pa\u017eeid\u017eiamos, pavyzd\u017eiui, sergant diabetu, sutrinka organizmo geb\u0117jimas reguliuoti cukraus kiek\u012f kraujyje.&nbsp;<\/p>\n\n\n\n<p>Tyr\u0117jai kasos \u03b2 l\u0105steles veik\u0117 dideliu gliukoz\u0117s ir lipid\u0173 kiekiu. <em>(riebal\u0173) <\/em>b\u016bkl\u0119, kuri atspindi diabeto sukelt\u0105 metabolin\u012f stres\u0105. Jie naudojo <a href=\"https:\/\/www.sigmaaldrich.com\/NL\/en\/product\/mm\/scc208\" target=\"_blank\" rel=\"noreferrer noopener\">\u017eiurki\u0173 insulinomos l\u0105steli\u0173 linija<\/a>, mokslinis modelis, naudojamas d\u0117l jo svarbos \u017emogaus \u03b2 l\u0105steli\u0173 funkcijai.&nbsp;<\/p>\n\n\n\n<p>Kai kurios l\u0105stel\u0117s buvo auginamos maistini\u0173 med\u017eiag\u0173 turtingoje terp\u0117je, po to jos buvo apdorotos tam tikros koncentracijos psilocibinu. Po gydymo psilocibinu l\u0105stel\u0117s buvo panardintos \u012f didelio gliukoz\u0117s ir lipid\u0173 kiekio terp\u0119, kad b\u016bt\u0173 sukelta \u012ftampa ir pa\u017eeidimai, paprastai pastebimi diabetu sergan\u010di\u0173 \u017emoni\u0173 kasos \u03b2 l\u0105stel\u0117se.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"640\" height=\"401\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/science-research-test-tube.jpg\" alt=\"\" class=\"wp-image-188832\" style=\"width:840px;height:auto\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/science-research-test-tube.jpg 640w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/science-research-test-tube-300x188.jpg 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/science-research-test-tube-18x12.jpg 18w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/science-research-test-tube-600x376.jpg 600w\" sizes=\"(max-width: 640px) 100vw, 640px\" \/><figcaption class=\"wp-element-caption\"><em><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-cyan-bluish-gray-color\">Julia Koblitz nuotrauka Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-psilocybin-protects-cells\">Psilocibinas apsaugo l\u0105steles<\/h3>\n\n\n\n<p>Tyr\u0117jai pasteb\u0117jo, kad l\u0105stel\u0117s, kurios buvo apdorotos psilocibinu, pasi\u017eym\u0117jo gerokai geresniu gyvybingumu, palyginti su l\u0105stel\u0117mis, kurios nebuvo apdorotos psilocibinu. \u0160i i\u0161vada rodo, kad psilocibinas turi apsaugin\u012f poveik\u012f kasos \u03b2 l\u0105stel\u0117ms, kuris padeda suma\u017einti su diabetu susijusio metabolinio streso \u017eal\u0105.&nbsp;<\/p>\n\n\n\n<p>Atlik\u0119 tolesn\u0119 analiz\u0119, mokslininkai gal\u0117jo pateikti \u012f\u017evalg\u0173, kod\u0117l psilocibinas gali tur\u0117ti tok\u012f apsaugin\u012f poveik\u012f. Naudodami<a href=\"https:\/\/en.wikipedia.org\/wiki\/Western_blot\" target=\"_blank\" rel=\"noreferrer noopener\">Western Blot<\/a>\" analiz\u0117 parod\u0117, kad gydant psilocibinu suma\u017e\u0117jo keli pagrindiniai apoptoz\u0117s biomarkeriai \u03b2 l\u0105stel\u0117se, kurios buvo veikiamos didelio gliukoz\u0117s ir lipid\u0173 kiekio, imituojan\u010dio diabet\u0105. <a href=\"https:\/\/en.wikipedia.org\/wiki\/Apoptosis\" target=\"_blank\" rel=\"noreferrer noopener\">Apoptoz\u0117<\/a> <em>(tai rei\u0161kia u\u017eprogramuot\u0105 l\u0105steli\u0173 mirt\u012f) <\/em>vaidina pagrindin\u012f vaidmen\u012f prarandant \u03b2 l\u0105steles sergant diabetu. Pasteb\u0117tas psilocibino geb\u0117jimas ma\u017einti su \u0161iuo procesu susijusius \u017eymenis pabr\u0117\u017eia jo potencial\u0105 i\u0161saugoti \u03b2 l\u0105steles sergant cukriniu diabetu.&nbsp;<\/p>\n\n\n\n<p>Reaguodamas \u012f \u012fdomius savo komandos rezultatus, Koval\u010diukas pasteb\u0117jo;<\/p>\n\n\n\n<p style=\"font-size:21px\"><em>\"Nesitik\u0117jome, kad psilocibinas taip gerai veiks kasos l\u0105steles,\"&nbsp;<\/em><\/p>\n\n\n\n<p>Jis taip pat sak\u0117 \"PsyPost\", kad;<\/p>\n\n\n\n<p><em>\"...mikrodozavimas magi\u0161kaisiais grybais grei\u010diausiai tur\u0117s teigiam\u0105 poveik\u012f \u017emon\u0117ms, sergantiems metaboliniu sindromu (prie\u0161 diabet\u0105) ir diabetu,\".<\/em><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"768\" height=\"644\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/astrodose-microdosing-psilocybin-strip-17.png\" alt=\"\" class=\"wp-image-188833\" style=\"width:506px;height:auto\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/astrodose-microdosing-psilocybin-strip-17.png 768w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/astrodose-microdosing-psilocybin-strip-17-300x252.png 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/astrodose-microdosing-psilocybin-strip-17-14x12.png 14w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/astrodose-microdosing-psilocybin-strip-17-600x503.png 600w\" sizes=\"(max-width: 768px) 100vw, 768px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-study-limitations-early-days\">Tyrimo apribojimai: Ankstyvasis etapas<\/h4>\n\n\n\n<p>Nors tai daug \u017eadanti prad\u017eia \u0161ioje tyrim\u0173 srityje, tyrimas turi tr\u016bkum\u0173, kurie rodo, kad reikia tolesni\u0173 tyrim\u0173 projekt\u0173. Vis\u0173 pirma, \u017einoma, tyrimas buvo atliktas naudojant \u017eiurki\u0173 insulinomos l\u0105steli\u0173 linij\u0105, kuri, nors ir tinkama labai ankstyviems tyrimams, negali visi\u0161kai atkartoti sud\u0117ting\u0173 gyvo organizmo savybi\u0173.&nbsp;<\/p>\n\n\n\n<p>Koval\u010diukas pa\u017eym\u0117jo; <em>\"Turime atlikti \u0161\u012f tyrim\u0105 su gyv\u016bnais, kad b\u016btume tikri, jog jis veikia taip pat gerai, kaip ir in vitro.\"&nbsp;<\/em><\/p>\n\n\n\n<p>Be to, \u0161iame tyrime buvo nagrin\u0117jamas tik psilocibino poveikis esant specifin\u0117ms streso s\u0105lygoms, kurias suk\u0117l\u0117 didelis gliukoz\u0117s ir lipid\u0173 kiekis. Tai tik vienas i\u0161 diabeto aspekt\u0173, kuris yra daugiafaktorin\u0117 liga, t. y. pasirei\u0161kia \u012fvairios patologijos, \u012fskaitant u\u017edegim\u0105, atsparum\u0105 insulinui, o 1 tipo diabeto atveju - ir autoimuninius komponentus.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-a-revolution-in-diabetes-treatment\">Diabeto gydymo revoliucija<\/h3>\n\n\n\n<p>\u0160io tyrimo esm\u0117 - galimas perversmas diabeto gydymo srityje. Tai labai svarbu, nes diabetas yra liga, kuri turi b\u016bti gydoma vis\u0105 \u017emogaus gyvenim\u0105. Daugelyje \u0161ali\u0173 cukriniu diabetu sergan\u010dio asmens sveikatai palaikyti reikalingi vaistai yra brang\u016bs, o ma\u017eesnes pajamas gaunantiems \u017emon\u0117ms da\u017enai aukojami vietoj maisto ar nuomos. Kaip sako Kolvachuk <em>\"Visada ie\u0161kome nat\u016bralesni\u0173, tradicini\u0173 ir holistini\u0173 lig\u0173 gydymo b\u016bd\u0173.\"<\/em><\/p>\n\n\n\n<figure class=\"wp-block-image alignright size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"1000\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-16.png\" alt=\"\" class=\"wp-image-188836\" style=\"width:362px;height:auto\" srcset=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-16.png 1000w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-16-300x300.png 300w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-16-150x150.png 150w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-16-768x768.png 768w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-16-12x12.png 12w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-16-600x600.png 600w, https:\/\/www.wholecelium.com\/wp-content\/uploads\/5-16-100x100.png 100w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/figure>\n\n\n\n<p><strong>Ar \u0161ie tyrimai gali pad\u0117ti sukurti ateit\u012f, kai \u017emon\u0117s gal\u0117s r\u016bpintis savo sveikata augindami nat\u016bralius vaistus? <\/strong><\/p>\n\n\n\n<p><strong>Tikim\u0117s!\u00a0<\/strong>????<\/p>","protected":false},"excerpt":{"rendered":"<p>Diabetu \u0161iuo metu serga 537 mln. \u017emoni\u0173 visame pasaulyje, ir \u0161is skai\u010dius tik did\u0117ja. Iki 2045 m. diabetu sirgs 783 mln. \u017emoni\u0173, tod\u0117l b\u016btina kurti veiksmingesnius ir prieinamesnius gydymo b\u016bdus. Naujas tyrimas rodo, kad magi\u0161kieji grybai gali b\u016bti svarb\u016bs.\u00a0<\/p>","protected":false},"author":4,"featured_media":189850,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88],"tags":[],"topics":[],"class_list":["post-188827","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/lt\/wp-json\/wp\/v2\/posts\/188827","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lt\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lt\/wp-json\/wp\/v2\/comments?post=188827"}],"version-history":[{"count":13,"href":"https:\/\/www.wholecelium.com\/lt\/wp-json\/wp\/v2\/posts\/188827\/revisions"}],"predecessor-version":[{"id":189860,"href":"https:\/\/www.wholecelium.com\/lt\/wp-json\/wp\/v2\/posts\/188827\/revisions\/189860"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lt\/wp-json\/wp\/v2\/media\/189850"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/lt\/wp-json\/wp\/v2\/media?parent=188827"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lt\/wp-json\/wp\/v2\/categories?post=188827"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lt\/wp-json\/wp\/v2\/tags?post=188827"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lt\/wp-json\/wp\/v2\/topics?post=188827"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}