{"id":166313,"date":"2023-12-18T15:27:31","date_gmt":"2023-12-18T14:27:31","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=166313"},"modified":"2023-12-18T15:27:35","modified_gmt":"2023-12-18T14:27:35","slug":"vai-psihedeliki-var-aizstat-opioidus-ka-atkaribu-nesaturosus-pretsapju-lidzeklus","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/lv\/blog\/can-psychedelics-replace-opioids-as-addiction-free-painkillers\/","title":{"rendered":"Vai psihed\u0113li\u0137i var aizst\u0101t opio\u012bdus k\u0101 no atkar\u012bbas br\u012bvus prets\u0101pju l\u012bdzek\u013cus?"},"content":{"rendered":"

M\u016bsu smadzenes ir smiekl\u012bgas vecas lietas. To specifisk\u0101 ma\u0123ija joproj\u0101m ir daudz\u0113j\u0101d\u0101 zi\u0146\u0101 nezin\u0101ma pat visatt\u012bst\u012bt\u0101kajiem neirozin\u0101tniekiem. Ta\u010du tie\u0161i m\u016bsu smadzenes ir t\u0101s, kas apstr\u0101d\u0101 un p\u0101rraida s\u0101pes, kuras m\u0113s izj\u016btam - gan emocion\u0101li, gan fiziski. Un \u0161o savstarp\u0113ji saist\u012bto apstr\u0101des meh\u0101nismu d\u0113\u013c robe\u017ea starp \u0161iem da\u017e\u0101dajiem s\u0101pju veidiem k\u013c\u016bst neskaidra.\u00a0<\/strong><\/p>\n\n\n\n

\"\"
izmantojot Pixabay<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

S\u0101pes bez iemesla<\/h2>\n\n\n\n

Tas ir visvair\u0101k redzams tiem, kuri cie\u0161 no nociplastisk\u0101s s\u0101pes<\/a>. Nociplastisk\u0101s s\u0101pes ir s\u0101pju veids, kam nav skaidra vai ac\u012bmredzama izrais\u012bt\u0101jfaktora, t\u0101d\u0113j\u0101di t\u0101s at\u0161\u0137iras no nocicept\u012bvais<\/a> vai neirop\u0101tiskas s\u0101pes. Tas ir visaptvero\u0161s termins, kas aptver da\u017e\u0101dus st\u0101vok\u013cus, s\u0101kot no disfunkcion\u0101l\u0101m s\u0101p\u0113m un beidzot ar neizskaidrojamiem \u0137erme\u0146a sindromiem. Tie ietver fibromial\u0123iju, musku\u013cu un skeleta s\u0101pes, piem\u0113ram, hroniskas muguras s\u0101pes, ur\u012bnp\u016b\u0161\u013ca s\u0101pju sindromu un kairin\u0101tu zarnu sindromu. T\u0101s var b\u016bt \u012bpa\u0161i traumatiskas tiem, kas cie\u0161 no \u0161iem trauc\u0113jumiem, jo nav iesp\u0113jams izsekot to c\u0113lo\u0146am, piem\u0113ram, traumai vai nervu boj\u0101jumam. Tas var izrais\u012bt netic\u012bbu vai, iesp\u0113jams, pat ap\u0161aub\u012bt vi\u0146u pa\u0161u realit\u0101tes izpratni. <\/p>\n\n\n\n

Probl\u0113mas ar opio\u012bdiem <\/h4>\n\n\n\n

Daudziem no \u0161iem cilv\u0113kiem nav citas iesp\u0113jas, k\u0101 vien \u0137erties pie prets\u0101pju l\u012bdzek\u013ciem, piem\u0113ram, opio\u012bdiem. Un, j\u016bs, bez \u0161aub\u0101m, esat las\u012bju\u0161i, ka opio\u012bdu epid\u0113mija ir vissmag\u0101k\u0101 probl\u0113ma. pa\u0161reiz\u0113jais posts<\/a> medic\u012bnas sist\u0113m\u0101. Opio\u012bdi vienlaikus rada b\u012bstamu atkar\u012bbu un ir neefekt\u012bvi s\u0101pju c\u0113lo\u0146u \u0101rst\u0113\u0161an\u0101. S\u0101kotn\u0113j\u0101s pacil\u0101t\u012bbas un nom\u0101kto s\u0101pju saj\u016btas nomaina pieaugo\u0161a tolerance un nav cita rezerves pl\u0101na k\u0101 vien turpin\u0101t lietot z\u0101les. <\/p>\n\n\n\n

Kad m\u0113s uz to raug\u0101mies \u0161\u0101di, k\u013c\u016bst skaidrs, k\u0101p\u0113c ir tik svar\u012bgi izp\u0113t\u012bt psihed\u0113liku potenci\u0101lu ne tikai fizisku, bet ar\u012b psiholo\u0123isku s\u0101pju \u0101rst\u0113\u0161an\u0101. Tas ir lo\u0123iski, vai ne? Gan depresija, gan hroniskas s\u0101pes ievainots. <\/em>Tie var saboj\u0101t m\u016bsu dz\u012bves kvalit\u0101ti. Un m\u016bsu pa\u0161reiz\u0113j\u0101s \u0101rst\u0113\u0161anas metodes izraisa, ja visp\u0101r kaut ko izraisa, vair\u0101k <\/em>ilgtermi\u0146\u0101. <\/p>\n\n\n\n

\"\"
caur Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Laika gait\u0101 psihod\u0113liskie l\u012bdzek\u013ci k\u013c\u016bst efekt\u012bv\u0101ki <\/h2>\n\n\n\n

T\u0101tad p\u0113t\u012bjumi atkal ir sniegu\u0161i daudzsolo\u0161us rezult\u0101tus, kas liecina, ka psihed\u0113li\u0137i var b\u016bt efekt\u012bvs<\/a> fizisko s\u0101pju \u0101rst\u0113\u0161an\u0101. Bet \u0161eit ir galvenais - \u0137irsis virs\u016b. \u0160\u0137iet, ka tie\u0161\u0101 pretstat\u0101 opio\u012bdiem psihed\u0113li\u0137i paties\u012bb\u0101 k\u013c\u016bst par... vair\u0101k <\/em>efekt\u012bva laika gait\u0101. Nervu s\u0101pju p\u0113t\u012bjumi liecina, ka t\u0101das z\u0101les k\u0101 psilocib\u012bns un LSD, kas iedarbojas uz seroton\u012bna receptoriem, atk\u0101rtotas lieto\u0161anas gad\u012bjum\u0101 patie\u0161\u0101m arvien vair\u0101k mazina s\u0101pes un diskomfortu. <\/p>\n\n\n\n

Nesen notiku\u0161aj\u0101 literat\u016bras apskats<\/a> p\u0113tnieki izp\u0113t\u012bja un sal\u012bdzin\u0101ja da\u017e\u0101dus p\u0113t\u012bjumus, kas aptver \u0161o psihed\u0113lisko vielu p\u0113t\u012bjumu jomu. Vi\u0146i atkl\u0101ja, ka psihod\u0113lisko l\u012bdzek\u013cu lieto\u0161ana fizisko s\u0101pju \u0101rst\u0113\u0161anai nav tik jauna, k\u0101 var\u0113tu dom\u0101t. Paties\u012bb\u0101 laik\u0101 no 1964. l\u012bdz 1977. gadam notika da\u017e\u0101di nelieli kl\u012bniskie p\u0113t\u012bjumi, kas pier\u0101d\u012bja, ka LSD var darboties k\u0101 efekt\u012bvs prets\u0101pju l\u012bdzeklis. \u0160ajos p\u0113t\u012bjumos pat tika konstat\u0113ts, ka psihed\u0113li\u0137i p\u0101rsp\u0113ja opio\u012bdus v\u0113\u017ea un gangr\u0113nas \u0101rst\u0113\u0161an\u0101. Ritiniet l\u012bdz m\u016bsdien\u0101m, un vair\u0101k cilv\u0113ku nek\u0101 jebkad agr\u0101k pa\u0161\u0101rst\u0113jas, izmantojot psilocib\u012bnu vai LSD, lai \u0101rst\u0113tu t\u0101das slim\u012bbas k\u0101 klastera galvass\u0101pes, un uzskata, ka t\u0101s ir daudz efekt\u012bv\u0101kas. <\/p>\n\n\n\n

\"\"
caur Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Darbs gan ar fizisk\u0101m, gan emocion\u0101l\u0101m s\u0101p\u0113m vienlaic\u012bgi<\/h3>\n\n\n\n

K\u0101 ar \u0161\u012bm viel\u0101m, kas rada tr\u012bsk\u0101r\u0161u saj\u016btu, tiek gal\u0101 ar s\u0101p\u0113m? Psilocib\u012bns un LSD at\u0161\u0137ir\u012bb\u0101 no opio\u012bdiem uzreiz un tie\u0161i nes\u0101k manipul\u0113t ar s\u0101pju receptoriem. Tom\u0113r, pateicoties seroton\u012bner\u0123iskajai iedarb\u012bbai, tie var b\u016bt ide\u0101li piem\u0113roti t\u0101du nociplastisku slim\u012bbu \u0101rst\u0113\u0161anai k\u0101 IBS, fibromial\u0123ija un kompleksais re\u0123ion\u0101lo s\u0101pju sindroms. (CRPS). <\/em>Taj\u0101 pa\u0161\u0101 literat\u016bras apskat\u0101 tika nor\u0101d\u012bts, ka \u0161ie medikamenti vienlaikus iedarbojas gan uz fizisk\u0101m s\u0101p\u0113m, gan uz emocion\u0101l\u0101 stresa c\u0113lo\u0146iem. <\/p>\n\n\n\n

Tie\u0161i \u0161\u012b iemesla d\u0113\u013c psihod\u0113liskie l\u012bdzek\u013ci var k\u013c\u016bt par jaunajiem prets\u0101pju l\u012bdzek\u013ciem. Psilocib\u012bns un LSD, \u0161\u0137iet, sp\u0113j p\u0101rveidot smadzenes t\u0101, ka t\u0101s maina attieksmi pret emocion\u0101lo stresu un padara t\u0101s maz\u0101k uz\u0146\u0113m\u012bgas pret fizisku s\u0101pju sign\u0101liem. \u0160\u012b sare\u017e\u0123\u012bt\u0101 nervu p\u0101rk\u0101rto\u0161an\u0101s ir \u013coti svar\u012bga, lai \u0101rst\u0113tu pacientus ar nociplastisk\u0101m s\u0101p\u0113m, jo vi\u0146u s\u0101pes uztvero\u0161ie neironi \u013coti viegli aktiviz\u0113jas, izraisot vi\u0146iem s\u0101pes, ko citi cilv\u0113ki nej\u016bt. \u0160\u0101da veida jut\u012bba bie\u017ei s\u0101kas ar visp\u0101r\u0113ju diskomfortu, bet laika gait\u0101 t\u0101 k\u013c\u016bst intens\u012bv\u0101ka. Galu gal\u0101 t\u0101 k\u013c\u016bst neizturam\u0101ka cietu\u0161ajam. <\/p>\n\n\n\n

Hroniskas s\u0101pes var main\u012bt m\u016bsu smadzenes<\/h4>\n\n\n\n

\u0160\u012b slim\u012bba var strauji p\u0101riet no ak\u016bta st\u0101vok\u013ca uz hronisku, jo \u0161\u016bnas maina rull\u012b\u0161us, \u0161\u016bnu olbaltumvielas tiek p\u0101rk\u0101rtotas un g\u0113ni s\u0101k darboties cit\u0101di. Galu gal\u0101 smadzenes, kas jau ir nepareizi p\u0101rvald\u012bju\u0161as fizisk\u0101s s\u0101pes, turpina dar\u012bt to pa\u0161u ar\u012b ar m\u016bsu emocion\u0101lajiem procesiem. Tas var izskaidrot, k\u0101p\u0113c cilv\u0113kiem, kuri cie\u0161 no hronisk\u0101m s\u0101p\u0113m, att\u012bst\u0101s ar\u012b trauksme un\/vai depresija. <\/p>\n\n\n\n

Hroniskas s\u0101pes pat maina noklus\u0113juma re\u017e\u012bma t\u012bklu (DMN), <\/em>m\u016bsu smadze\u0146u t\u012bkla da\u013ca, kas saist\u012bta ar dom\u0101m par sevi. Gan cilv\u0113kiem, kas cie\u0161 no depresijas, gan hronisk\u0101m nociplatisk\u0101m s\u0101p\u0113m, DMN ir neparasti augsts aktivit\u0101tes l\u012bmenis, un \u0161\u0137iet, ka t\u0101 ir atdal\u012bta no cit\u0101m smadze\u0146u da\u013c\u0101m, kas apstr\u0101d\u0101 emocijas un s\u0101pes. Tas ir saist\u012bts ar sevis aps\u0113st\u012bbu un negat\u012bv\u0101m domu cilp\u0101m. <\/p>\n\n\n\n

\"\"
caur Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Galvenais ir smadze\u0146u daudzveid\u012bba<\/h4>\n\n\n\n

Kad psihed\u0113li\u0137i mijiedarbojas ar smadze\u0146u seroton\u012bna receptoriem, piem\u0113ram, 5-HT2A, tie palielina smadze\u0146u \"entropiju\". Tas ir k\u0101 m\u016bsu smadze\u0146u bag\u0101t\u012bba un daudzveid\u012bba - tas palielina saikni ar cit\u0101m smadze\u0146u da\u013c\u0101m, pal\u012bdzot mums atbr\u012bvoties no DMN pa\u0161kontroles. Tiek uzskat\u012bts, ka \u0161is process reset\u0113 m\u016bsu smadzenes, pied\u0101v\u0101jot jaunu veidu, k\u0101 \u0101rst\u0113t gan hroniskas s\u0101pes, gan emocion\u0101las cie\u0161anas. <\/p>\n\n\n\n

Iekaisums ir v\u0113l viens b\u016btisks hronisku s\u0101pju un depresijas izrais\u012bt\u0101js. Ir pier\u0101d\u012bts, ka psihed\u0113li\u0137i mazina iekaisumu, k\u0101 ar\u012b veicina smadze\u0146u \u0161\u016bnu aug\u0161anu un savieno\u0161anu.<\/p>\n\n\n\n

Holistisk\u0101 \u0101rst\u0113\u0161ana dziedino\u0161\u0101 pasaul\u0113<\/h2>\n\n\n\n
\"\"<\/figure>\n\n\n\n

Medic\u012bnas zin\u0101tnei k\u013c\u016bstot arvien sare\u017e\u0123\u012bt\u0101kai, k\u013c\u016bst arvien skaidr\u0101ks, ka m\u016bsu \"es\" ir sare\u017e\u0123\u012bta kombin\u0101cija, kas ir vien\u0101d\u0101s da\u013c\u0101s gan m\u016bsu fiziskais \u0137ermenis, gan m\u016bsu emocion\u0101l\u0101 un gar\u012bg\u0101 b\u016bt\u012bba. Pr\u0101tu nevar no\u0161\u0137irt no \u0137erme\u0146a, un \u0137ermeni nevar no\u0161\u0137irt no pr\u0101ta, kad runa ir par piln\u012bgu dziedin\u0101\u0161anu. Psihed\u0113li\u0137i ir viena no vien\u012bgaj\u0101m viel\u0101m, kas sp\u0113j m\u016bs \u0101rst\u0113t holistiski, iedarbojoties uz m\u016bsu pr\u0101tu, \u0137ermeni un garu. Jo vair\u0101k m\u0113s p\u0113t\u012bsim to nosl\u0113pumaino iedarb\u012bbu, jo lab\u0101k. <\/p>","protected":false},"excerpt":{"rendered":"

Pa\u0161reiz\u0113jo psihed\u0113lisko p\u0113t\u012bjumu vilni m\u0113s parasti asoci\u0113jam ar gar\u012bg\u0101s vesel\u012bbas jomu. Depresija, trauksme, PTSD - visus \u0161os st\u0101vok\u013cus var iev\u0113rojami uzlabot, lietojot psihed\u0113li\u0137us, piem\u0113ram, psilocib\u012bnu. Tom\u0113r jaun\u0101kie p\u0113t\u012bjumi atkl\u0101ja, ka \u0161\u012bs vielas var \u0101rst\u0113t ar\u012b fiziskas s\u0101pes, k\u0101 ar\u012b gar\u012bg\u0101s cie\u0161anas. Un, iesp\u0113jams, abas \u0161\u012bs vielas var\u0113tu b\u016bt vair\u0101k saist\u012btas, nek\u0101 j\u016bs s\u0101kotn\u0113ji dom\u0101j\u0101t...<\/p>","protected":false},"author":4,"featured_media":167391,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88,68],"tags":[],"topics":[],"class_list":["post-166313","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-studies","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/166313","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/comments?post=166313"}],"version-history":[{"count":11,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/166313\/revisions"}],"predecessor-version":[{"id":167398,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/166313\/revisions\/167398"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/media\/167391"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/media?parent=166313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/categories?post=166313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/tags?post=166313"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/topics?post=166313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}