{"id":188282,"date":"2024-04-15T16:28:57","date_gmt":"2024-04-15T14:28:57","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=188282"},"modified":"2024-04-15T16:30:39","modified_gmt":"2024-04-15T14:30:39","slug":"petijuma-konstatets-ka-dabiskais-psilocibins-ir-efektivaks-par-sintetiskajam-kopijam","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/lv\/blog\/study-finds-natural-psilocybin-more-effective-than-synthetic-copies\/","title":{"rendered":"P\u0113t\u012bjum\u0101 konstat\u0113ts, ka dabiskais psilocib\u012bns ir efekt\u012bv\u0101ks nek\u0101 sint\u0113tisk\u0101s kopijas"},"content":{"rendered":"

Jauns p\u0113t\u012bjums<\/a>, kas sal\u012bdzina<\/strong>s dabisk\u0101 psilocib\u012bna un sint\u0113tisk\u0101 psilocib\u012bna iedarb\u012bbu, ir konstat\u0113ts, ka dab\u0101 sastopamais s\u0113\u0146u ekstrakts ir terapeitiski efekt\u012bv\u0101ks nek\u0101 sintez\u0113t\u0101 versija. \u0160ie secin\u0101jumi liecina, ka dab\u0101 sastopamajam psilocib\u012bnam var b\u016bt liel\u0101kas iesp\u0113jas g\u016bt pan\u0101kumus nopietnu gar\u012bg\u0101s vesel\u012bbas trauc\u0113jumu, piem\u0113ram, depresijas, \u0161izofr\u0113nijas un PTSD, \u0101rst\u0113\u0161an\u0101.\u00a0<\/strong><\/p>\n\n\n\n

Dabas Vs. Sint\u0113tiskais<\/h2>\n\n\n\n

P\u0113t\u012bjumu veica p\u0113tnieku komanda no Jeruzalemes Ebreju Universit\u0101tes Hada\u0161as Medic\u012bnas centra BrainLabs psihod\u0113lisko p\u0113t\u012bjumu centrs. <\/em>P\u0113t\u012bjuma m\u0113r\u0137is bija sal\u012bdzin\u0101t un pretstat\u012bt dab\u0101 sastopam\u0101 psilocib\u012bna iedarb\u012bbu uz organismu. (no burvju s\u0113n\u0113m) <\/em>ar sintez\u0113tu psilocib\u012bnu, (bie\u017ei tiek izmantots \u012bstas preces viet\u0101)<\/em> psihed\u0113lisko vielu p\u0113t\u012bjumos.\u00a0<\/p>\n\n\n\n

Bernards Lerers, psihiatrijas profesors un universit\u0101tes direktors, past\u0101st\u012bja PsyPost;<\/p>\n\n\n\n

\"Mani kol\u0113\u0123i un mani \u013coti interes\u0113 psihed\u0113li\u0137u potenci\u0101ls nopietnu, pret \u0101rst\u0113\u0161anu rezistentu psihisku trauc\u0113jumu, piem\u0113ram, depresijas, PTSD, OKT un pat \u0161izofr\u0113nijas, \u0101rst\u0113\u0161an\u0101.<\/em><\/p>\n\n\n\n

...Ir daudz anekdotisku un kl\u012bnisku zi\u0146ojumu, kas liecina, ka psilocib\u012bnu saturo\u0161u s\u0113\u0146u ekstraktam var b\u016bt unik\u0101la iedarb\u012bba, kas kvalitat\u012bvi un kvantitat\u012bvi at\u0161\u0137iras no \u0137\u012bmisk\u0101 psilocib\u012bna, k\u0101 ar\u012b da\u017ei prekl\u012bniskie p\u0113t\u012bjumi,\". <\/em><\/p>\n\n\n\n

Komanda v\u0113l\u0113j\u0101s p\u0101rbaud\u012bt \u0161os zi\u0146ojumus, nor\u0101dot, ka rezult\u0101tiem b\u016btu j\u0101b\u016bt. \"svar\u012bgas kl\u012bnisk\u0101s sekas.\"<\/em><\/p>\n\n\n\n

\"\"
Sint\u0113tisk\u0101 psilocib\u012bna test\u0113\u0161ana... via DeepDreamGenerator<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Vai entourage efekts pastiprina psilocib\u012bna terapeitisko iedarb\u012bbu?<\/h3>\n\n\n\n

Ja esat ma\u0123isk\u0101s mikolo\u0123ijas cien\u012bt\u0101js, j\u016bs, iesp\u0113jams, esat dzird\u0113jis parsv\u012btas efekts<\/a>'. T\u0101 ir \u012bpa\u0161a psihoakt\u012bvo un nepsihoakt\u012bvo savienojumu kombin\u0101cija, kas dabiski sastopama psilocib\u012bna s\u0113n\u0113s. Tie rada kopum\u0101 <\/strong>psihed\u0113liskais efekts. Kad psilocib\u012bnu sintez\u0113 laboratorijas vajadz\u012bb\u0101m, tiek izdal\u012bts tikai galvenais psihoakt\u012bvais savienojums, bet netiek izdal\u012bti visi ar to saist\u012btie savienojumi. Da\u013c\u0113ji tas tiek dar\u012bts, lai ieg\u016btu vielu ar visviendab\u012bg\u0101k paredzamu iedarb\u012bbu, un da\u013c\u0113ji t\u0101p\u0113c, ka tiek atveidots le\u0123end\u0101rais entourage efekts, it k\u0101, it k\u0101, nevar izdar\u012bt.\u00a0<\/em><\/p>\n\n\n\n

Pazi\u0146ojum\u0101 par p\u0113t\u012bjumu p\u0113tnieki paskaidroja; <\/p>\n\n\n\n

\"Rietumu medic\u012bn\u0101 v\u0113sturiski ir bijusi priek\u0161roka akt\u012bvo savienojumu izol\u0113\u0161anai, nevis ekstrakta izmanto\u0161anai.<\/em>s. Galvenok\u0101rt t\u0101p\u0113c, lai lab\u0101k kontrol\u0113tu devas un \u0101rst\u0113\u0161anas laik\u0101 paredz\u0113tu zin\u0101mo iedarb\u012bbu... Probl\u0113mas, str\u0101d\u0101jot ar ekstraktiem, rad\u012bja tas, ka agr\u0101k nebija iesp\u0113jams konsekventi ra\u017eot prec\u012bzu produktu ar viendab\u012bgu savienojumu profilu.\"<\/em><\/p>\n\n\n\n

\"\"
izmantojot DeepDreamGenerator<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Vi\u0146i turpin\u0101ja;<\/p>\n\n\n\n

\"Pretstat\u0101 tam sen\u0101s medic\u012bnas prakses, \u012bpa\u0161i t\u0101s, kas pied\u0113v\u0113ja terapeitisko labumu psihed\u0113lisk\u0101m z\u0101l\u0113m, ietv\u0113ra ekstraktu vai veselu produktu lieto\u0161anu, piem\u0113ram, pat\u0113r\u0113jot visu s\u0113ni... Lai gan Rietumu medic\u012bna jau sen ir atzinusi ar veseliem ekstraktiem saist\u012bto \"pavado\u0161o\" efektu, \u0161\u012bs pieejas noz\u012bme ir k\u013cuvusi paman\u0101m\u0101ka nesen.\"<\/em><\/p>\n\n\n\n

K\u0101 tika veikts p\u0113t\u012bjums<\/h4>\n\n\n\n

P\u0113t\u012bjums tika veikts ar laboratorijas pel\u0113m. P\u0113tnieki t\u0101s sadal\u012bja tr\u012bs grup\u0101s; viena sa\u0146\u0113ma dab\u012bgo psilocib\u012bna s\u0113\u0146u ekstraktu, otra - sintez\u0113to versiju, bet tre\u0161\u0101 - fiziolo\u0123isko \u0161\u0137\u012bdumu k\u0101 kontroli. Pel\u0113m, kas sa\u0146\u0113ma k\u0101du no psilocib\u012bna form\u0101m, tika dota deva, kas atbilst devai, kura b\u016btu terapeitiski noz\u012bm\u012bga cilv\u0113kam.\u00a0<\/p>\n\n\n\n

P\u0113tnieki nov\u0113roja un nov\u0113rt\u0113ja psilocib\u012bna ietekmi uz pe\u013cu uzved\u012bbu un potenci\u0101lo neiroplasticit\u0101ti. Vi\u0146i to veica, izmantojot \"galvas raust\u012b\u0161an\u0101s reakcijas testu\". \u0160\u012b ir pla\u0161i izmantota metode, lai p\u0113t\u012btu psihed\u0113lisko vielu iedarb\u012bbu uz grauz\u0113jiem. P\u0113c \u0101rst\u0113\u0161anas vi\u0146i ar\u012b sal\u012bdzin\u0101ja vielmai\u0146as izmai\u0146as front\u0101laj\u0101 garoz\u0101 un analiz\u0113ja sinaptisko prote\u012bnu ekspresiju smadzen\u0113s. \u0160o efektu m\u0113r\u012bjumus var izmantot k\u0101 neiroplasticit\u0101tes r\u0101d\u012bt\u0101jus, t. i., smadze\u0146u sp\u0113ju main\u012bties, piel\u0101goties un augt.\u00a0<\/em><\/p>\n\n\n\n

\"\"
caur Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Dabiskais psilocib\u012bns izce\u013cas uz aug\u0161u<\/h3>\n\n\n\n

P\u0113tnieki atkl\u0101ja, ka s\u0113\u0146u ekstrakts (dabiskais psilocib\u012bns) <\/em>rad\u012bja sp\u0113c\u012bg\u0101ku un ilgsto\u0161\u0101ku ietekmi uz sinaptisko plastiskumu. Tas nor\u0101da, ka dab\u0101 sastopamais savienojums sniedz unik\u0101las terapeitiskas priek\u0161roc\u012bbas, kuras sintez\u0113t\u0101 versija nevar piel\u012bdzin\u0101t. P\u0113c anal\u012bzes tika konstat\u0113ts, ka sintez\u0113t\u0101 psilocib\u012bna un dab\u012bg\u0101 ekstrakta metaboliskie profili ir at\u0161\u0137ir\u012bgi. Tas liecina, ka dab\u012bgajam ekstraktam var b\u016bt \"unik\u0101la ietekme uz oksidat\u012bvo stresu un ener\u0123ijas ra\u017eo\u0161anas ce\u013ciem.<\/em>.\"<\/em> (Via Neuroscience News.)<\/em><\/p>\n\n\n\n

P\u0113tnieki konstat\u0113ja, ka dabiskajam un sintez\u0113tajam psilocib\u012bnam ir at\u0161\u0137ir\u012bga iedarb\u012bba dzi\u013c\u0101k\u0101 l\u012bmen\u012b, (piem\u0113ram, neiroplastisko un metabolisko). <\/em>uzved\u012bbas l\u012bmen\u012b reakcija bija l\u012bdz\u012bga, ar sal\u012bdzin\u0101mu galvas raust\u012b\u0161an\u0101s reakciju. Tas liecina, ka uzved\u012bbas pamatl\u012bmen\u012b dabisko un sint\u0113tisko savienojumu ak\u016bt\u0101 iedarb\u012bba ir l\u012bdz\u012bga.\u00a0<\/p>\n\n\n\n

\"\"
Foto - Igor Omilaev on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Profesors Lerers teica;<\/p>\n\n\n\n

\"M\u016bs p\u0101rsteidza fakts, ka starp \u0137\u012bmisk\u0101 psilocib\u012bna un psilocib\u012bnu saturo\u0161a s\u0113\u0146u ekstrakta ak\u016bt\u0101 iedarb\u012bb\u0101 uz galvas raust\u012b\u0161an\u0101s reakciju nebija nek\u0101du at\u0161\u0137ir\u012bbu, bet at\u0161\u0137ir\u012bbas par\u0101d\u012bj\u0101s attiec\u012bb\u0101 uz ilgtermi\u0146a ietekmi uz sinaptiskiem prote\u012bniem un metabolomiku... Tam ir svar\u012bga potenci\u0101la kl\u012bniska noz\u012bme.\"<\/em><\/p>\n\n\n\n

Sint\u0113tisko psilocib\u012bnu var b\u016bt viegl\u0101k prognoz\u0113t p\u0113t\u012bjumos<\/h4>\n\n\n\n

Tas noteikti pier\u0101da, ka dabiskais psilocib\u012bns ir daudz lab\u0101ks par sintez\u0113to. Un, protams, m\u0113s esam vienispr\u0101tis.<\/strong>. ???? Tom\u0113r kl\u012bniskaj\u0101 praks\u0113 sint\u0113tiskais psilocib\u012bns bie\u017ei vien ir praktisk\u0101ka izv\u0113le. Tas ir t\u0101p\u0113c, ka ir viegl\u0101k nodro\u0161in\u0101t konsekventu iedarb\u012bbu un efektu . Neraugoties uz to, p\u0113tnieki nor\u0101da, ka, ja dabiskais psilocib\u012bns patie\u0161\u0101m nodro\u0161ina lab\u0101ku iedarb\u012bbu, ar r\u016bp\u012bgu apstr\u0101di un kultiv\u0113\u0161anu var\u0113tu b\u016bt iesp\u0113jams izgatavot dabiskus ekstraktus ar konsekventiem sast\u0101viem. \u0160\u0137iet, ka tas noteikti var\u0113tu b\u016bt lietder\u012bgi!<\/p>\n\n\n\n

P\u0113tnieki rakst\u012bja;<\/p>\n\n\n\n

\"Galvenais izaicin\u0101jums dab\u012bgo ekstraktu gad\u012bjum\u0101 ir pan\u0101kt konsekventi stabilu savienojumu profilu, jo \u012bpa\u0161i augu gad\u012bjum\u0101, tom\u0113r s\u0113nes ir unik\u0101ls gad\u012bjums... S\u0113\u0146u savienojumus liel\u0101 m\u0113r\u0101 ietekm\u0113 to aug\u0161anas vide, kas ietver t\u0101dus faktorus k\u0101 substr\u0101ta sast\u0101vs, CO2\/O2 attiec\u012bba, gaismas iedarb\u012bba, temperat\u016bra un mikrobiolo\u0123isk\u0101 vide. Neraugoties uz \u0161\u012bm ietekm\u0113m, kontrol\u0113ta audz\u0113\u0161ana \u013cauj pieradin\u0101t s\u0113nes, \u013caujot ieg\u016bt atk\u0101rtojamu ekstraktu.\"<\/em><\/p>\n\n\n\n

P\u0113tnieki secin\u0101ja, ka nepiecie\u0161ami papildu p\u0113t\u012bjumi, vienlaikus uzsverot, ka dabisk\u0101 psilocib\u012bna lieto\u0161ana var sniegt iev\u0113rojamu kl\u012bnisku labumu, nevis sint\u0113tisk\u0101 psilocib\u012bna lieto\u0161ana.\u00a0<\/p>\n\n\n\n

Profesors Lerers paskaidroja;<\/p>\n\n\n\n

\"M\u016bsu atkl\u0101jumi ir j\u0101apstiprina p\u0113t\u012bjumos ar cilv\u0113kiem, ta\u010du tie liecina, ka psilocib\u012bnu saturo\u0161s s\u0113\u0146u ekstrakts var sniegt terapeitiskas priek\u0161roc\u012bbas sal\u012bdzin\u0101jum\u0101 ar \u0137\u012bmiski sintez\u0113tu psilocib\u012bnu, ja abus lieto vien\u0101d\u0101 psilocib\u012bna dev\u0101,\".\u00a0<\/em><\/p>\n\n\n\n

Dabas veltes<\/h2>\n\n\n\n

T\u0101tad atkal \u0161\u0137iet, ka daba ???? zina vislab\u0101k. Un, ja j\u016bs<\/em> v\u0113laties dabisk\u0101, autentisk\u0101 psilocib\u012bna - m\u0113s zin\u0101m vietu, kur to dabiski ieg\u016bt... <\/p>\n\n\n\n

\"\"<\/a>
Apmekl\u0113jiet m\u016bsu interneta veikalu jau \u0161odien!<\/em><\/figcaption><\/figure>","protected":false},"excerpt":{"rendered":"

K\u0101 saka vecais teiciens: \"Daba zina vislab\u0101k.\" Vi\u0146a nesteidzas. Viss ir l\u012bdzsvar\u0101. Nekas netiek izniekots. Un, k\u0101 mums bija aizdomas, vi\u0146a sav\u0101s s\u0113n\u0113s ra\u017eo vislab\u0101ko, ma\u0123isk\u0101ko psilocib\u012bnu. B\u016bt\u012bb\u0101 \u0161ie laboratorijas m\u0113te\u013ci var\u0113tu m\u0113\u0123in\u0101t, bet paties\u012bb\u0101 - vi\u0146i nekad nevar\u0113tu m\u0113\u0123in\u0101t.\u00a0<\/p>","protected":false},"author":4,"featured_media":188295,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[90,88],"tags":[],"topics":[],"class_list":["post-188282","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-product-knowledge","category-psychedelic-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/188282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/comments?post=188282"}],"version-history":[{"count":9,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/188282\/revisions"}],"predecessor-version":[{"id":188848,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/188282\/revisions\/188848"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/media\/188295"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/media?parent=188282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/categories?post=188282"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/tags?post=188282"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/topics?post=188282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}