{"id":207459,"date":"2024-08-30T17:12:18","date_gmt":"2024-08-30T15:12:18","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=207459"},"modified":"2024-08-30T17:12:59","modified_gmt":"2024-08-30T15:12:59","slug":"apstiprinats-ka-psilocibins-ir-efektivaks-par-tradicionalajiem-antidepresantiem","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/lv\/blog\/confirmed-psilocybin-more-effective-than-traditional-antidepressant\/","title":{"rendered":"Apstiprin\u0101ts: Psilocib\u012bns efekt\u012bv\u0101ks par tradicion\u0101lo antidepresantu"},"content":{"rendered":"

Depresija skar vair\u0101k nek\u0101 280 miljonus cilv\u0113ku vis\u0101 pasaul\u0113. T\u0101 ir galvenais invalidit\u0101tes c\u0113lonis vis\u0101 pasaul\u0113, kas skar vair\u0101k nek\u0101 3,8% iedz\u012bvot\u0101ju. Neraugoties uz to, ir gr\u016bti atrast piem\u0113rotas \u0101rst\u0113\u0161anas iesp\u0113jas. Lai gan da\u017eiem cilv\u0113kiem pieejamie antidepresanti iedarbojas, lielai da\u013cai cilv\u0113ku tie ir neefekt\u012bvi vai izraisa nepat\u012bkamas blakuspar\u0101d\u012bbas. <\/strong><\/p>\n\n\n\n

Sacen\u0161amies, lai atrastu efekt\u012bv\u0101kus, holistisk\u0101kus un pieejam\u0101kus risin\u0101jumus. Pa\u0161laik l\u012bderis ir psihed\u0113li\u0137i; aizvien vair\u0101k p\u0113t\u012bjumu liecina, ka tie var pal\u012bdz\u0113t \u0101rst\u0113t veselu virkni gar\u012bg\u0101s vesel\u012bbas trauc\u0113jumu, tostarp, protams, depresiju. <\/p>\n\n\n\n

\"\"
Foto - Stormseeker on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n
Svar\u012bgi ir sal\u012bdzino\u0161ie p\u0113t\u012bjumi<\/h5>\n\n\n\n

Lai gan ir pier\u0101d\u012bts, ka psihed\u0113li\u0137i, piem\u0113ram, psilocib\u012bns no burvju s\u0113n\u0113m. efekt\u012bvs depresijas \u0101rst\u0113\u0161an\u0101<\/a>, bet \u012bstais sp\u0113ks ir tad, kad to rezult\u0101ti tiek sal\u012bdzin\u0101ti un sal\u012bdzin\u0101ti ar tradicion\u0101l\u0101s depresijas \u0101rst\u0113\u0161anas rezult\u0101tiem. \u0160\u0101di p\u0113t\u012bjumi pa\u0161laik tiek veikti ret\u0101k, da\u013c\u0113ji t\u0101p\u0113c, ka 20. gadsimta otraj\u0101 pus\u0113 psihed\u0113liju p\u0113t\u012bjumi bija p\u0101rtraukti. Tom\u0113r, p\u0101rskats un metaanal\u012bze<\/a>, kas \u0161om\u0113nes public\u0113ts \u017eurn\u0101l\u0101 BMJ <\/em>tie\u0161i t\u0101 ar\u012b ir dar\u012bts, sal\u012bdzinot psilocib\u012bna iedarb\u012bbu ar antidepresantu escitalopr\u0101mu. <\/p>\n\n\n\n

P\u0101rskata rezult\u0101ti liecina, ka lielas psilocib\u012bna devas bija efekt\u012bv\u0101kas nek\u0101 escitaloprams depresijas simptomu mazin\u0101\u0161an\u0101. Tas liecina, ka psilocib\u012bns var b\u016bt (vismaz)<\/em> sal\u012bdzin\u0101ma ar antidepresantu terapiju. <\/p>\n\n\n\n

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caur Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Psihod\u0113lisko l\u012bdzek\u013cu sal\u012bdzin\u0101jums ar citiem depresijas \u0101rst\u0113\u0161anas veidiem<\/h3>\n\n\n\n

M\u0113s esam p\u0101rliecin\u0101ti, ka j\u016bs zin\u0101t, (bet gad\u012bjum\u0101, ja ir k\u0101di jaunpien\u0101c\u0113ji) <\/em>psihed\u0113li\u0137i ir psihoakt\u012bvas vielas, da\u017eas dab\u0101 sastopamas (psilocib\u012bns, ayahuasca<\/a>)<\/em>, da\u017ei sint\u0113tiskie (LSD, MDMA)<\/em>, kas izraisa psihed\u0113lisko ce\u013cojumu. L\u012bdztekus izklaides, gar\u012bgajai un pr\u0101tu maino\u0161ajai iedarb\u012bbai tiem ir potenci\u0101ls \u0101rst\u0113t daudzus gar\u012bg\u0101s vesel\u012bbas trauc\u0113jumus, piem\u0113ram, p\u0113ctraumatisko stresa sindromu. (PTSD<\/a>), <\/em>\u0113\u0161anas trauc\u0113jumi, piem\u0113ram. anoreksija<\/a>, atkar\u012bbas probl\u0113mas<\/a>, k\u0101 ar\u012b depresija un daudzas citas. <\/p>\n\n\n\n

Neskatoties uz to, cik daudzsolo\u0161i ir biju\u0161i psihed\u0113li\u0137u p\u0113t\u012bjumu rezult\u0101ti, vienm\u0113r ir gr\u016bti veikt pien\u0101c\u012bgi \"aklus\" p\u0113t\u012bjumus psihed\u0113li\u0137u subjekt\u012bv\u0101s iedarb\u012bbas d\u0113\u013c. Tas noz\u012bm\u0113, ka placebo efekts un iesp\u0113jam\u0101 neobjektivit\u0101te var k\u013c\u016bt izteikt\u0101ka. <\/p>\n\n\n\n

K\u0101 notika p\u0101rskat\u012b\u0161ana<\/h2>\n\n\n\n

Jaun\u0101 BMJ p\u0101rskata p\u0113tnieki v\u0113l\u0113j\u0101s sal\u012bdzin\u0101t monoterapijas (tikai vienas z\u0101les) <\/em>psihed\u0113liku lieto\u0161ana kop\u0101 ar escitalopramu, pla\u0161i izplat\u012btu farmaceitisku antidepresantu. Lai l\u012bdzsvarotu psihed\u0113liku izm\u0113\u0123in\u0101jumos potenci\u0101li maz\u0101ku placebo efektu, autori uzsv\u0113ra, ka j\u0101no\u0161\u0137ir psihed\u0113liku izm\u0113\u0123in\u0101jumos re\u0123istr\u0113t\u0101 placebo reakcija un antidepresantu p\u0113t\u012bjumos re\u0123istr\u0113t\u0101 placebo reakcija. <\/p>\n\n\n\n

P\u0113tnieki iek\u013c\u0101va izlases veida kontrol\u0113tus p\u0113t\u012bjumus ar pieaugu\u0161ajiem dal\u012bbniekiem, kuriem bija diagnostic\u0113ta kl\u012bnisk\u0101 depresija. Visos datos k\u0101 prim\u0101ro rezult\u0101tu vi\u0146i mekl\u0113ja depresijas simptomu izmai\u0146as. Kopum\u0101 vi\u0146i var\u0113ja iek\u013caut datus no 19 p\u0113t\u012bjumiem. Tajos bija iek\u013cauti 811 dal\u012bbnieki psihod\u0113liskos p\u0113t\u012bjumos un 1968 dal\u012bbnieki escitalopr\u0101ma p\u0113t\u012bjumos. Apkopojot datus, p\u0113tnieki konstat\u0113ja, ka placebo efekts psihed\u0113lisko l\u012bdzek\u013cu p\u0113t\u012bjumos bija maz\u0101ks nek\u0101 placebo efekts escitalopr\u0101ma p\u0113t\u012bjumos. <\/p>\n\n\n\n

Apstiprin\u0101ts: Psilocib\u012bns efekt\u012bv\u0101ks par tradicion\u0101lo antidepresantu<\/h5>\n\n\n\n

P\u0113t\u012bjum\u0101 konstat\u0113ts, ka lielas devas (20 mg vai vair\u0101k) <\/em>psilocib\u012bna bija nedaudz efekt\u012bv\u0101kas nek\u0101 escitaloprams.<\/p>\n\n\n\n

\"\"
izmantojot Creative Commons<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

\"Psilocib\u012bns liel\u0101s dev\u0101s ir daudzsolo\u0161s...\"<\/em><\/h4>\n\n\n\n

Dr. Deivids Merrils (David Merrill), Providence Saint John's Health Center Santa Monik\u0101 geriatrisk\u0101s psihiatrijas \u0101rsts, kur\u0161 p\u0113t\u012bjum\u0101 netika iesaist\u012bts, izdevumam Medical News Today par p\u0101rskat\u0101 iek\u013cautajiem secin\u0101jumiem sac\u012bja sekojo\u0161o:<\/p>\n\n\n\n

\"\u0160aj\u0101 p\u0113t\u012bjum\u0101, izmantojot metaanal\u012bzes metodes, tika sal\u012bdzin\u0101ta psihed\u0113li\u0137u un escitalopr\u0101ma (Lexapro) efektivit\u0101te depresijas simptomu \u0101rst\u0113\u0161an\u0101... Psilocib\u012bns liel\u0101s dev\u0101s ir daudzsolo\u0161s k\u0101 \u0101tras iedarb\u012bbas, \u012bstermi\u0146a depresijas \u0101rst\u0113\u0161anas l\u012bdzeklis. Tas ir sal\u012bdzin\u0101jum\u0101 ar antidepresantiem, kuru iedarb\u012bba s\u0101kas p\u0113c ned\u0113\u013c\u0101m vai pat m\u0113ne\u0161iem un turpina darboties tikai p\u0113c ilgsto\u0161as lieto\u0161anas,\".<\/em><\/p>\n\n\n\n

\"Lai gan \u0161aj\u0101 p\u0113t\u012bjum\u0101 tas nav apl\u016bkots, kl\u012bnisk\u0101 vienpr\u0101t\u012bba ir t\u0101da, ka lielas psilocib\u012bna devas var sniegt labumu m\u0113ne\u0161iem un, iesp\u0113jams, gadiem ilgi p\u0113c ak\u016bt\u0101s \u0101rst\u0113\u0161anas epizodes. Reiz\u0113m pat ir nepiecie\u0161ama tikai viena \u0101rst\u0113\u0161anas sesija cit\u0101di hroniskas, gr\u016bti \u0101rst\u0113jamas depresijas gad\u012bjum\u0101. Tas ir viens no iemesliem, k\u0101p\u0113c psihod\u0113lisk\u0101 psihoterapija ar psihod\u0113lisko l\u012bdzek\u013cu pal\u012bdz\u012bbu dro\u0161\u0101, kontrol\u0113t\u0101 profesion\u0101l\u0101 vid\u0113 psiholo\u0123ijas un psihiatrijas jom\u0101 g\u016bst tik lielu impulsu un entuziasmu,\". <\/em><\/p>\n\n\n\n

K\u0101 var\u0113tu uzlabot psihod\u0113liskos izm\u0113\u0123in\u0101jumus? <\/h3>\n\n\n\n

P\u0113t\u012bjuma autori ierosina, ka, uzlabojot aklas metodes un nodro\u0161inot standartiz\u0113t\u0101ku psihoterapiju, var\u0113tu uzlabot izpratni par psihed\u0113liku efektivit\u0101ti. Da\u017ei p\u0113tnieki ir kritiz\u0113ju\u0161i secin\u0101jumus, sakot, ka sal\u012bdzin\u0101tie p\u0113t\u012bjumi ir p\u0101r\u0101k at\u0161\u0137ir\u012bgi, lai tos var\u0113tu uzskat\u012bt par atbilsto\u0161iem. <\/p>\n\n\n\n

Tom\u0113r \u0161\u012b p\u0113t\u012bjuma p\u0113tnieki uzskata, ka \u0161ie rezult\u0101ti liecina, ka psilocib\u012bnam ir re\u0101ls potenci\u0101ls, ko var izmantot l\u012bdztekus psihoterapeitiskajam atbalstam. Doktors Deivids Merrils (David Merrill) tam piekr\u012bt, apgalvojot: \"Psihsilocibiotiskais prepar\u0101ts ir \u013coti noder\u012bgs; <\/p>\n\n\n\n

\"\u0160ie atkl\u0101jumi dod cer\u012bbu cilv\u0113kiem ar depresiju, jo \u012bpa\u0161i tiem, kuriem antidepresanti ir neefekt\u012bvi vai nav pie\u0146emami blakuspar\u0101d\u012bbu d\u0113\u013c. Lai gan vienm\u0113r past\u0101v iesp\u0113jamie riski, lietojot z\u0101les vesel\u012bbas st\u0101vok\u013ca \u0101rst\u0113\u0161anai, \u0161is p\u0101rskats liecina, ka, iev\u0113rojot pareizu dom\u0101\u0161anas veidu un \u0101rst\u0113\u0161anas nosac\u012bjumus, lielas psihed\u0113liku devas var dro\u0161i un efekt\u012bvi lietot depresijas \u0101rst\u0113\u0161anai, un rezult\u0101ti ir l\u012bdzv\u0113rt\u012bgi vai lab\u0101ki nek\u0101 ar antidepresantiem.\"<\/em><\/p>\n\n\n\n

\"Daudzi \u0161aj\u0101 jom\u0101 c\u012bt\u012bgi str\u0101d\u0101, lai izveidotu atjaunotu pier\u0101d\u012bjumu b\u0101zi, kas \u013cautu legaliz\u0113t un reglament\u0113ti apstiprin\u0101t psilocib\u012bna un citu psihod\u0113lisko terapiju depresijas, PTSD, atkar\u012bbas un citu vesel\u012bbas st\u0101vok\u013cu \u0101rst\u0113\u0161anai,\". <\/em><\/p>\n\n\n\n

\"\"
caur Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Ieg\u016btais rezult\u0101ts:<\/h3>\n\n\n\n
    \n
  • Ir pier\u0101d\u012bts, ka psihod\u0113liskie l\u012bdzek\u013ci ir efekt\u012bvi psihisko slim\u012bbu \u0101rst\u0113\u0161an\u0101.<\/li>\n\n\n\n
  • P\u0113t\u012bjumi, kuros psihed\u0113li\u0137i tiek sal\u012bdzin\u0101ti ar tradicion\u0101lajiem medikamentiem, pa\u0161laik ir sal\u012bdzino\u0161i maz. <\/li>\n\n\n\n
  • Jaun\u0101 BMJ p\u0113t\u012bjuma apskats liecina, ka lielas psilocib\u012bna devas ir nedaudz efekt\u012bv\u0101kas depresijas \u0101rst\u0113\u0161an\u0101 nek\u0101 escitaloprams - pla\u0161i izplat\u012bts antidepresants. <\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"

    Nesen veikt\u0101 p\u0113t\u012bjumu p\u0101rskat\u0101 konstat\u0113ts, ka lielas psilocib\u012bna (no burvju s\u0113n\u0113m) devas ir efekt\u012bv\u0101kas nek\u0101 parastais antidepresants escitaloprams.<\/p>","protected":false},"author":4,"featured_media":207614,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88,68],"tags":[],"topics":[],"class_list":["post-207459","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-studies","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/207459","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/comments?post=207459"}],"version-history":[{"count":7,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/207459\/revisions"}],"predecessor-version":[{"id":207615,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/207459\/revisions\/207615"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/media\/207614"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/media?parent=207459"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/categories?post=207459"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/tags?post=207459"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/topics?post=207459"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}