{"id":47545,"date":"2022-02-22T11:09:07","date_gmt":"2022-02-22T10:09:07","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=47545"},"modified":"2023-05-10T08:03:45","modified_gmt":"2023-05-10T06:03:45","slug":"petijumi-liecina-ka-ssris-nepartrauc-psilocibina-darbibu","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/lv\/blog\/studies-show-ssris-do-not-stop-psilocybin-working\/","title":{"rendered":"P\u0113t\u012bjumi liecina, ka SSAI neaptur psilocib\u012bna darb\u012bbu"},"content":{"rendered":"

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\u00a0\u0160\u012b viela, kas iepriek\u0161 tika uzskat\u012bta par vienu no b\u012bstamaj\u0101m narkotik\u0101m, piem\u0113ram, hero\u012bnu un koka\u012bnu, un kas ir augsti pacelta uz zin\u0101tnisko p\u0113t\u012bjumu un p\u0113t\u012bjumu pleciem, jau sen ir main\u012bjusi savu t\u0113lu.\u00a0<\/strong><\/p>\n

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izmantojot Creative Commons<\/em><\/mark><\/figcaption>\n<\/figure>\n

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R\u016bgt\u0101 ironija cilv\u0113kiem ar depresiju<\/h2>\n

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Tas patie\u0161\u0101m nevar notikt pietiekami \u0101tri. Tas ir ne tikai diezgan traki, ka viela, kas nov\u0113rt\u0113ta k\u0101 vismaz\u0101k b\u012bstam\u0101 izklaides narkotika<\/a> (ar<\/em> \u013coti lega<\/em><\/strong>l alkohola reitings ir vismaz 10 reizes liel\u0101ks, lai j\u016bs nok\u013c\u016btu nepat\u012bkam\u0101 situ\u0101cij\u0101!)<\/em> joproj\u0101m ir aizliegta, miljoniem cilv\u0113ku vis\u0101 pasaul\u0113 var\u0113tu g\u016bt labumu no psilocib\u012bna ma\u0123ijas. <\/p>\n

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L\u012bdz \u0161im \u0161is br\u012bnumainais savienojums ir izmantots, lai \u0101rst\u0113tu da\u017e\u0101dus apst\u0101k\u013cus, s\u0101kot no depresija<\/a>, PTSD<\/a>, trauksme, atkar\u012bba<\/a>un \u0113\u0161anas trauc\u0113jumi. Tas patie\u0161\u0101m ir diezgan aizraujo\u0161i. Tom\u0113r v\u0113l nesen r\u016bgt\u0101 ironija<\/strong> pievienots \u0161im strauji augo\u0161ajam veiksmes st\u0101stam. Ilgu laiku vald\u012bja uzskats, ka psilocib\u012bna v\u0113lamo iedarb\u012bbu mazin\u0101s tradicion\u0101lo antidepresantu un medikamentu pret trauksmi lieto\u0161ana. Galven\u0101 uzman\u012bba tika piev\u0113rsta Selekt\u012bvie seroton\u012bna atpaka\u013csaistes inhibitori<\/em> vai \"SSAI\". <\/p>\n

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Foto - Nastya Dulhiier on Unsplash<\/mark><\/em><\/figcaption>\n<\/figure>\n

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Padom\u0101jiet par to... tiem, kuri visvair\u0101k v\u0113las psilocib\u012bna pal\u012bdz\u012bbu, trauc\u0113 medikamenti, kurus vi\u0146i pa\u0161laik lieto. Run\u0101jam par netaisn\u012bbu!<\/p>\n

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Probl\u0113mas ar SSAI<\/h2>\n

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Turkl\u0101t ir daudz iemeslu, k\u0101p\u0113c k\u0101ds var\u0113tu v\u0113l\u0113ties p\u0101rtraukt tradicion\u0101lo farmaceitisko z\u0101\u013cu lieto\u0161anu. Protams, daudziem cilv\u0113kiem t\u0101s darbojas. Bet daudziem cilv\u0113kiem t\u0101s nedarbojas. Var gad\u012bties, ka t\u0101m nav nek\u0101das iedarb\u012bbas vai t\u0101 ir \u013coti maza. T\u0101s rada emocion\u0101lu nejut\u012bgumu, ko nav iesp\u0113jams paciest. Ka daudz\u0101s blakuspar\u0101d\u012bbas ir p\u0101r\u0101k smagas, lai ar t\u0101m tiktu gal\u0101. Vai pat tas, ka lietot\u0101js nev\u0113las ievad\u012bt organism\u0101 nedabiskas \u0137imik\u0101lijas. <\/p>\n

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Lai ar\u012b cik \u013coti da\u017ei lietot\u0101ji ar t\u0101m c\u012bn\u0101s, daudziem tie ir vai nu medikamenti, vai ar\u012b cie\u0161 no depresijas vai trauksmes, kas vi\u0146us v\u0101jina. Tas apdraud vi\u0146u pa\u0161u dro\u0161\u012bbu, k\u0101 ar\u012b attiec\u012bbas ar tuviniekiem un profesion\u0101l\u0101s saist\u012bbas. <\/p>\n

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Foto - Gadiel Lazcano on Unsplash<\/em><\/mark><\/figcaption>\n<\/figure>\n

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Gan psilocib\u012bns, gan SSAI mijiedarbojas ar neiromediatoru seroton\u012bns<\/a>, bet \u013coti at\u0161\u0137ir\u012bgos veidos. SSAI aiztur seroton\u012bnu smadzen\u0113s un bie\u017ei vien var apsl\u0101p\u0113t emocion\u0101lo reakciju. Turpret\u012b psilocib\u012bns saist\u0101s ar receptoriem un stimul\u0113 tos, t\u0101d\u0113j\u0101di palielinot emocion\u0101lo saikni. <\/p>\n

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Agr\u0101k tika ieteikts, ka SSAI lietot\u0101jam pirms psilocib\u012bna lieto\u0161anas vajadz\u0113tu ats\u0101kt lietot. Daudziem lietot\u0101jiem tas ir probl\u0113ma, jo vi\u0146i izjut\u012bs iev\u0113rojamu fizisku un gar\u012bgu abstinenci, k\u0101 ar\u012b vi\u0146u slim\u012bbas simptomu atgrie\u0161anos. Tas ir daudz, jo \u012bpa\u0161i, ja v\u0113lam\u0101 \u0101rst\u0113\u0161ana daudzviet ir neleg\u0101la vai gr\u016bti pieejama. <\/p>\n

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Jauni p\u0113t\u012bjumi liecina, ka var kombin\u0113t SSAI un psilocib\u012bnu<\/h2>\n

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T\u0101p\u0113c ar visliel\u0101ko saj\u016bsmu m\u0113s varam zi\u0146ot, ka divi jaun\u0101kie p\u0113t\u012bjumi, kas tika public\u0113ti 2021. gada nogal\u0113 ned\u0113\u013cu laik\u0101, liecina par to, ka tas faktiski ir ne <\/em>gad\u012bjum\u0101. J\u016bs varat kombin\u0113t SSAI un psilocib\u012bnu bez negat\u012bvas ietekmes uz ab\u0101m viel\u0101m! <\/p>\n

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Vispirms biotehnolo\u0123iju uz\u0146\u0113mums MindMed<\/a>, kas 2021. gada novembr\u012b public\u0113ja datus, kuri par\u0101d\u012bja psilocib\u012bna un SSAI mijiedarb\u012bbu cilv\u0113kiem. P\u0113t\u012bjum\u0101, ko veica B\u0101zeles Universit\u0101tes slimn\u012bca, tika konstat\u0113ts, ka dal\u012bbnieki, kuri lietoja SSAI escitaloprams<\/em> joproj\u0101m izjuta psilocib\u012bna pozit\u012bvo ietekmi uz garast\u0101vokli. Sal\u012bdzinot ar placebo grupu, vi\u0146iem bija ar\u012b maz\u0101ka iesp\u0113ja, ka psilocib\u012bns var izrais\u012bt negat\u012bvas sekas, piem\u0113ram, trauksmi. <\/p>\n

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Foto - jesse orrico on Unsplash<\/em><\/mark><\/figcaption>\n<\/figure>\n

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P\u0113t\u012bjum\u0101 da\u017eiem dal\u012bbniekiem septi\u0146as dienas katru dienu deva 10 mg escitalopr\u0101ma, p\u0113c tam n\u0101kam\u0101s septi\u0146as dienas, ieskaitot psilocib\u012bna lieto\u0161anas dienu, - 20 mg escitalopr\u0101ma dien\u0101. P\u0101r\u0113jie divas ned\u0113\u013cas lietoja placebo l\u012bdz psilocib\u012bna ievad\u012b\u0161anai. <\/p>\n

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Atbildes uz galvenajiem jaut\u0101jumiem<\/h2>\n

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P\u0113t\u012bjuma galvenais p\u0113tnieks Dr. Matiass L\u012bhti (Matthias Liechti) paskaidroja, uz k\u0101diem jaut\u0101jumiem vi\u0146i cer\u0113ja rast atbildes ar savu p\u0113t\u012bjumu:<\/p>\n

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\"Pirmk\u0101rt, vai dro\u0161\u012bbas apsv\u0113rumu d\u0113\u013c pacientam pirms psilocib\u012bna lieto\u0161anas vajadz\u0113tu p\u0101rtraukt antidepresantu lieto\u0161anu? Otrk\u0101rt, ja nav dro\u0161\u012bbas riska, vai antidepresanti mazin\u0101s pacienta reakciju uz psilocib\u012bnu?\"<\/em><\/p>\n

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Un vi\u0146i var\u0113ja uz tiem atbild\u0113t:<\/p>\n

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\"\u0160ie rezult\u0101ti liecina, ka psilocib\u012bnu var lietot escitalopr\u0101ma terapijas laik\u0101 bez ac\u012bmredzamas ietekmes uz psilocib\u012bna iedarb\u012bbu. T\u0101d\u0113j\u0101di p\u0113t\u012bjums sniedz atbildi uz pirmo jaut\u0101jumu un pozit\u012bvu nor\u0101di uz otro.\" (Dr. Liechti) <\/em><\/p>\n

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Labs pirmais solis, un tas mudina veikt vair\u0101k p\u0113t\u012bjumu, k\u0101 to uzsv\u0113ra MindMed izpildprezidente Dr. Miri Halperin Wernli;<\/p>\n

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\"Ja rezult\u0101ti apstiprin\u0101sies turpm\u0101kajos p\u0113t\u012bjumos ar cit\u0101m viel\u0101m un ar pacientiem, nevis veseliem cilv\u0113kiem, iesp\u0113jams, ka psilocib\u012bna terapijas laik\u0101 vairs neb\u016bs j\u0101p\u0101rtrauc lietot antidepresantus,\". <\/em><\/p>\n

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Kompasa ce\u013ci atrod t\u0101du pa\u0161u rezult\u0101tu<\/h2>\n

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Un, vai j\u016bs to nezin\u0101t? Da\u017eu ned\u0113\u013cu laik\u0101 Kompasa ce\u013ci<\/a> izlaida savus datus ar vair\u0101k v\u0113lamajiem pier\u0101d\u012bjumiem...<\/p>\n

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Compass Pathways p\u0113t\u012bjum\u0101 sal\u012bdzin\u0101mi rezult\u0101ti tika konstat\u0113ti dal\u012bbniekiem, kuri joproj\u0101m lietoja SSAI, un tiem, kuri pirms p\u0113t\u012bjuma bija p\u0101rtrauku\u0161i to lieto\u0161anu, kad vi\u0146iem tika doti. COMP360. COMP360 <\/em>ir jauns psilocib\u012bna ekstrakts, ko kompass Pathways rad\u012bjis \u012bpa\u0161i terapeitiskai lieto\u0161anai. <\/p>\n

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Compass Pathways galvenais \u0101rsts Gajs Gudvins pazi\u0146oja:<\/p>\n

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\"\u0160\u012b p\u0113t\u012bjuma rezult\u0101ti ap\u0161auba pla\u0161i izplat\u012bto uzskatu, ka SSAI medikamentu lieto\u0161ana kop\u0101 ar psilocib\u012bnu var\u0113tu trauc\u0113t psilocib\u012bna terapeitisko iedarb\u012bbu. M\u016bsu atkl\u0101jumi ir sp\u0113c\u012bgs sign\u0101ls, ka psilocib\u012bna terapija ar COMP360 var\u0113tu b\u016bt papildterapija ar SSAI antidepresantiem, k\u0101 ar\u012b monoterapija.\"<\/em><\/p>\n

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A <\/em>\"monoterapija\" ir viens medikaments <\/strong>\u0101rst\u0113\u0161ana. T\u0101tad, ko vi\u0146\u0161 ir sakot <\/em>ir, ka psilocib\u012bnu var\u0113tu izmantot gan k\u0101 vienreiz\u0113ju \u0101rst\u0113\u0161anu (k\u0101 m\u0113s zin\u0101j\u0101m)<\/em> un<\/strong> <\/em>kop\u0101 ar SSAI. <\/p>\n

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Burvju s\u0113\u0146u m\u012btu grau\u0161ana!<\/h2>\n

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Phew! Diezgan daudz m\u012btu sagr\u0101vei. T\u0101s ir lieliskas zi\u0146as tiem, kas pa\u0161laik lieto SSAI un v\u0113las \u0101rst\u0113ties ar psilocib\u012bnu - bie\u017ei vien tiem, kam tas visvair\u0101k nepiecie\u0161ams. <\/p>\n

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Sekojiet \u0161ai vietnei, lai uzzin\u0101tu vair\u0101k pozit\u012bvu atkl\u0101jumu!<\/p>\n

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Ja pl\u0101nojat main\u012bt medikamentus vai labsaj\u016btu, vienm\u0113r konsult\u0113jieties ar savu \u0101rstu.<\/em>.<\/p>\n

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P\u0113d\u0113jo p\u0101ris gadu laik\u0101 psilocib\u012bns - akt\u012bv\u0101 viela burvju s\u0113n\u0113s un trifel\u0113s - tiek uzskat\u012bts par lielo cer\u012bbu gar\u012bg\u0101s vesel\u012bbas \u0101rst\u0113\u0161an\u0101.<\/p>","protected":false},"author":4,"featured_media":47646,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88],"tags":[],"topics":[],"class_list":["post-47545","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/47545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/comments?post=47545"}],"version-history":[{"count":2,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/47545\/revisions"}],"predecessor-version":[{"id":123347,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/posts\/47545\/revisions\/123347"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/media\/47646"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/media?parent=47545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/categories?post=47545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/tags?post=47545"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/lv\/wp-json\/wp\/v2\/topics?post=47545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}