{"id":15803,"date":"2020-10-27T16:31:00","date_gmt":"2020-10-27T16:31:00","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=15165"},"modified":"2023-11-02T13:33:55","modified_gmt":"2023-11-02T12:33:55","slug":"composto-anti-inflamatorio-encontrado-nos-psicadelicos","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/pt\/blog\/anti-inflammatory-compound-found-in-psychedelics\/","title":{"rendered":"Composto Anti-inflamat\u00f3rio Encontrado em Psicad\u00e9licos"},"content":{"rendered":"<\/p>\n\n\n

Anti-Inflammatory Compound Found In Psychedelics<\/em><\/h2>\n\n\n\n<\/p>\n

Powerful psychedelic compounds such as psilocybin<\/a> (from magic mushrooms<\/strong>)<\/em>, DMT<\/strong> and LSD<\/strong> have gained support from science in recent years. There has been much published research showing exactly how psychedelics can work as anti-inflammatory agents<\/strong>.<\/p>\n

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Now, researchers from Louisiana State University Health Sciences Center<\/strong> have discovered a compound called 2C-H<\/strong>. This was found to produce the best anti-inflammatory results in tests. It turns out, 2C-H is very similar on a molecular level to the psychedelic drug 2C-B. <\/em><\/p>\n

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There’s Always Space For Serotonin<\/em><\/h2>\n

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Psychedelic drugs spark their desired effect on the brain by attaching to a serotonin receptor<\/strong> in the brain called 5HT-2A<\/a><\/strong>.<\/p>\n

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Serotonin<\/a><\/strong>, a.k.a. \u201cThe Happy Hormone\u201d, reduces inflammation in the body\u2019s immune cells. Therefore, the more serotonin is secreted, the better for patients with conditions such as asthma<\/strong> and arthritis<\/strong>.<\/p>\n

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Now, Think Of Psychedelics as a Substitute For Serotonin <\/em><\/h2>\n

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Like serotonin, psychedelic drugs also spark the 5HT-2A receptor. Thus, substances like psilocybin may help reduce inflammation as well. But here\u2019s the strange part. 2C-H\u2014 though present in psychedelics \u2014has absolutely no psychoactive effects in itself…<\/p>\n

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2C-H: A Psychedelic Compound Without the High <\/em><\/h2>\n

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\"diagram
Researchers have confirmed the efficacy of 2-CH in a rat model of asthma. Note that 2-CH\u2019s anti-inflammatory aspect works separately from the \u201ctrippy\u201d effect. This opens the possibility of a \u201cno-trip\u201d experience for asthma patients who take psilocybin for relief at present.<\/em> Photo courtesy: ACS Pharmacol.<\/strong><\/figcaption><\/figure>\n\n\n<\/p>\n\n\n<\/p>\n

The researchers tested 21 different compounds on rats with symptoms for asthma. <\/p>\n

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(This was done to check for any link between \u201ccanonical signaling pathways\u201d<\/strong> which handles the \u201ctrippy\u201d part, and the desired anti-inflammatory effect.)<\/em><\/p>\n

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Since all of the psychedelic compounds activated the 5HT-2A receptor, many of them were able to prevent (and even reverse)<\/em> inflammation in the lungs. And guess what? Anti-inflammatory effects from 2-CH do not correlate with \u201cbehavioral activity\u201d or tripping out\u2026 at all.<\/p>\n

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\u201cPsychedelic drugs can make [a] strong anti-inflammatory effect. However, anti-inflammatory effects do not appear to correlate with behavioral activity, suggesting different underlying mechanisms.\u201d <\/em><\/p>\n

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– from ACS Pharmacology & Translational Science (2020) <\/strong><\/p>\n

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Testing 2C-H for Inflammation in Allergic Asthma<\/em><\/h2>\n

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The 21 agonists<\/strong> (or drugs that bind to and activate a receptor)<\/em> were taken from the 3 primary chemotypes, based on their ability to prevent symptoms of asthma.<\/p>\n

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Some of these symptoms include:<\/p>\n

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