{"id":14811,"date":"2020-10-06T15:46:00","date_gmt":"2020-10-06T15:46:00","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=14811"},"modified":"2023-05-11T14:22:53","modified_gmt":"2023-05-11T12:22:53","slug":"dmt-pentru-depresia-rezistenta-la-tratament","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/ro\/blog\/dmt-for-treatment-resistant-depression\/","title":{"rendered":"DMT pentru depresia rezistent\u0103 la tratament"},"content":{"rendered":"<h2 class=\"wp-block-heading\" id=\"h-dmt-for-treatment-resistant-depression\"><em>DMT pentru depresia rezistent\u0103 la tratament <\/em><\/h2>\n\n\n<p><strong>Este o problem\u0103 care a urm\u0103rit mult timp tratamentul s\u0103n\u0103t\u0103\u021bii mintale, f\u0103r\u0103 a fi promi\u021b\u0103toare. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3363299\/\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\">alternative<\/a>. Acesta este un blocaj grav \u0219i cronic \u00een calea solu\u021bion\u0103rii crizei de s\u0103n\u0103tate mintal\u0103, care afecteaz\u0103 aproape <a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\">264 de milioane de oameni<\/a> la nivel mondial.<\/strong><\/p>\n\n\n<h2 class=\"wp-block-heading\" id=\"h-enter-dmt\"><em>Introduce\u021bi DMT...<\/em><\/h2>\n\n\n\n<p>\u00cen efortul de a aborda depresia rezistent\u0103 la tratament, ATAI Life Sciences, o companie de biotehnologie, a lansat <strong><a href=\"https:\/\/viridia.life\/\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\">Viridia Life Sciences<\/a><\/strong> pentru a dezvolta noi formul\u0103ri de N,N-dimetiltriptimin\u0103 <em>(cunoscut \u0219i sub numele de compus psihedelic<a href=\"https:\/\/www.healthline.com\/health\/what-is-dmt\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\"> <strong>DMT<\/strong><\/a>)<\/em> ca poten\u021bial tratament.&nbsp;<\/p>\n\n\n\n<figure><img decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/2020\/10\/Screen-Shot-2020-08-31-at-13.28.59-scaled-1.jpg\" alt=\"\" \/>\n<figcaption><mark>Fotografii cu curtoazie: Micii atomi<\/mark><\/figcaption>\n<\/figure>\n\n\n\n<p>Viridia pl\u0103nuie\u0219te acum s\u0103 studieze poten\u021ba DMT-ului cu ajutorul <strong><a href=\"https:\/\/www.statnews.com\/2020\/02\/20\/digital-therapeutics-vs-digital-care\/\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\">terapeutic\u0103 digital\u0103<\/a><\/strong>, care sunt programe sau aplica\u021bii concepute pentru anumite afec\u021biuni (de exemplu, boala pulmonar\u0103 obstructiv\u0103 cronic\u0103 (<a href=\"https:\/\/www.nhs.uk\/conditions\/chronic-obstructive-pulmonary-disease-copd\/symptoms\/\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\">BPOC<\/a>) mai degrab\u0103 dec\u00e2t boli pulmonare; sau depresie, mai degrab\u0103 dec\u00e2t s\u0103n\u0103tate mintal\u0103).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-treating-resistant-depression-with-dmt\"><em>Tratarea depresiei rezistente cu DMT <\/em><\/h2>\n\n\n\n<p>Cunoscut\u0103 \u0219i sub numele de <em>\"molecula de spirit\"<\/em>, DMT poate fi g\u0103sit at\u00e2t \u00een plante c\u00e2t \u0219i \u00een animale - inclusiv \u00een oameni - \u0219i a fost ingerat \u00een scopuri rituale de c\u0103tre popula\u021biile indigene de mii de ani (\u0219i da, DMT <em>este<\/em> principalul ingredient activ din <a href=\"https:\/\/www.healthline.com\/nutrition\/ayahuasca\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\">ayahuasca<\/a>.<\/p>\n\n\n\n<p>Unele dintre efectele mentale ale DMT includ:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Depersonalizarea,<\/li>\n\n\n\n<li>Halucina\u021bii extreme,<\/li>\n\n\n\n<li>Sentimentul alterat al timpului<\/li>\n\n\n\n<li>Un sentiment de \"plutire\"<\/li>\n\n\n\n<li>Euforie.<\/li>\n<\/ul>\n\n\n\n<p>Cercet\u0103rile au ar\u0103tat acum c\u0103 DMT poate trata afec\u021biuni precum anxietatea, stresul post-traumatic \u0219i depresia - poate chiar s\u0103 ofere o solu\u021bie cu ac\u021biune rapid\u0103 pentru depresia rezistent\u0103. Cum este posibil acest lucru?<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-here-s-how\"><em>Iat\u0103 cum!<\/em><\/h2>\n\n\n\n<p>Teste in vitro<em> (care se refer\u0103 la studierea celulelor sau moleculelor biologice \"\u00een sticl\u0103\", \u00een afara gazdelor lor normale)<\/em> pentru modelele animale au ar\u0103tat noi cre\u0219teri de celule cerebrale cu mai multe conexiuni <em>(a.k.a. neuroplasticitate)<\/em> dup\u0103 ce a luat DMT. Aceste cre\u0219teri sunt adesea legate de \u00eembun\u0103t\u0103\u021birea simptomelor de depresie. Efectele DMT, a\u0219a cum sunt observate pe o electroencefalogram\u0103 <em>(EEG)<\/em> a prezentat, de asemenea, acelea\u0219i modific\u0103ri ale undelor cerebrale care, odat\u0103, au fost teoretizate ca fiind utile \u00een cazul depresiei.<\/p>\n\n\n\n<figure><img decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/2020\/10\/Screen-Shot-2020-08-31-at-13.28.59-1-scaled-1.jpg\" alt=\"\" \/>\n<figcaption><mark>Creierul t\u0103u pe DMT, a\u0219a cum se vede \u00eentr-o electroencefalogram\u0103 <em>(EEG)<\/em> model. Fotografie:<strong> BioRxiv.org<\/strong><\/mark><\/figcaption>\n<\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-not-just-intravenously-new-ways-of-taking-dmt\"><em> Nu doar intravenos: Noi moduri de a lua DMT <\/em><\/h2>\n\n\n\n<p>De\u0219i DMT este adesea administrat intravenos, Viridia inten\u021bioneaz\u0103 s\u0103 creeze mai multe produse DMT bazate pe alte c\u0103i de administrare. <strong>Glenn Short, PhD<\/strong>, CEO al Viridias, a explicat:<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><p><em> \"DMT administrat prin perfuzie intravenoas\u0103 (IV) nu este \u00eentotdeauna de scurt\u0103 durat\u0103 \u0219i este, de asemenea, foarte intens. Ceea ce ne propunem noi este s\u0103 folosim chimia formulei pentru a putea \u00eencetini debutul efectelor compusului, precum \u0219i pentru a controla durata \u0219i durata experien\u021bei, astfel \u00eenc\u00e2t aceasta s\u0103 fie mai gradual\u0103 \u0219i, \u00een general, s\u0103 fie o experien\u021b\u0103 mai bl\u00e2nd\u0103 \u0219i mai pl\u0103cut\u0103 pentru pacient. Putem regla cu adev\u0103rat fin modul \u00een care este eliberat un medicament.\" <\/em><\/p><\/p>\n\n\n\n<p>Aceasta este o veste bun\u0103 pentru pacien\u021bii cu fobie de ace, deoarece pot alege o form\u0103 mai pu\u021bin invaziv\u0103 de administrare a DMT.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-pairing-dmt-with-psychotherapy-for-maximum-effect\"><em>Asocierea DMT cu psihoterapia pentru un efect maxim <\/em><\/h2>\n\n\n\n<p>Viridian inten\u021bioneaz\u0103 s\u0103 se foloseasc\u0103 de timpul de \u00eenjum\u0103t\u0103\u021bire scurt al DMT \u00een clinic\u0103 pentru a induce o experien\u021b\u0103 psihedelic\u0103, urmat\u0103 imediat de o \u0219edin\u021b\u0103 de psihoterapie.&nbsp;<\/p>\n\n\n\n<p>Aceast\u0103 combina\u021bie s-a dovedit a fi cea mai benefic\u0103 pentru subiec\u021bi - a\u0219a cum a ar\u0103tat o meta-analiz\u0103 recent\u0103 a 20 de studii pentru anxietate \u0219i depresie, prin combinarea unui medicament psihedelic cu psihoterapia.<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><p><em> \"DMT reprezint\u0103 o oportunitate de a ajunge la cei care nu pot sau nu doresc s\u0103 se supun\u0103 unei experien\u021be psihedelice mai lungi.\" <\/em><\/p><\/p>\n\n\n\n<p>- Florian Brand, CEO al ATAI Life Sciences.<\/p>\n\n\n\n<p>De data aceasta, \u00eens\u0103, Viridias va folosi <em>digital<\/em> terapeutice care s\u0103 urmeze administr\u0103rii de DMT. Poten\u021bialii subiec\u021bi se pot a\u0219tepta la o serie de aplica\u021bii specializate ca \"linie direct\u0103 de comunicare\" cu terapeutul lor.<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><p><em>\"Prin asocierea terapiei digitale cu terapia DMT, putem preg\u0103ti subiectul pentru aceast\u0103 experien\u021b\u0103 \u00een prealabil - dar putem, de asemenea, s\u0103 monitoriz\u0103m pacientul dup\u0103 terapie. Pacientul... ar putea, de asemenea, s\u0103 poat\u0103 discuta cu alte persoane care sunt supuse acelora\u0219i tipuri de tratamente.\" <\/em><\/p><\/p>\n\n\n\n<p>- Glenn Short, PhD, CEO al Viridias.<\/p>\n\n\n\n<p>Terapia digital\u0103 le permite terapeu\u021bilor s\u0103 monitorizeze pacien\u021bii \u00een timp real. De asemenea, asigur\u0103 un sprijin continuu pentru pacient, dincolo de clinic\u0103.<\/p>\n\n\n\n<p>Este interesant de observat c\u0103 nici m\u0103car unul dintre studiile din cadrul studiului <strong><a href=\"http:\/\/:https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/da.23065\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\">meta-analiz\u0103<\/a><\/strong> a constatat c\u0103 doar substan\u021ba era suficient\u0103. Aceasta este diferen\u021ba esen\u021bial\u0103 \u00eentre consumul de psihedelice \u00een scop recreativ \u0219i cele administrate \u00een clinic\u0103.  Deocamdat\u0103, compania va fi supus\u0103 unei serii de studii preclinice privind farmacologia \u0219i toxicologia \u00eenainte de a putea depune cererea de reglementare. Abia atunci Viridias va avea permisiunea de a trece la studiile de faz\u0103 1.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-implications-for-mental-health-in-2020\"><em>Implica\u021bii pentru s\u0103n\u0103tatea mintal\u0103 \u00een 2020<\/em><\/h2>\n\n\n\n<p>Actuala pandemie de COVID-19 a for\u021bat o mul\u021bime de oameni s\u0103 tr\u0103iasc\u0103 \u00een s\u0103r\u0103cie \u0219i izolare, ceea ce, potrivit unui avertisment recent al ONU, ar putea duce la <strong>agraveaz\u0103 criza de s\u0103n\u0103tate mintal\u0103<\/strong>.<\/p>\n\n\n\n<p>Cu toate acestea, s-a constatat c\u0103 multe dintre tratamentele prescrise pentru depresie, cum ar fi SSRI, pot provoca<a href=\"https:\/\/www.health.harvard.edu\/mind-and-mood\/what-are-the-real-risks-of-antidepressants\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\"> alte probleme de s\u0103n\u0103tate mintal\u0103<\/a>, cum ar fi <em>\"cre\u0219terea g\u00e2ndurilor suicidare, a ostilit\u0103\u021bii \u0219i a agita\u021biei\"<\/em> la copii, adolescen\u021bi \u0219i adul\u021bi tineri.<\/p>\n\n\n\n<p>Pentru mul\u021bi pacien\u021bi care se str\u0103duiesc s\u0103 g\u0103seasc\u0103 stabilitate, schimbarea constant\u0103 a medicamentelor Big Pharma \u00eei poate priva de un sentiment de echilibru \u0219i normalitate - ceea ce duce apoi la perioade de recidiv\u0103. \u00cen acest caz, pacien\u021bii nu sunt singurii afecta\u021bi; familia lor trebuie adesea s\u0103 sufere \u0219i ea efectele acesteia. Astfel, tratamentele alternative pentru depresie, cum ar fi psihedelicele, sunt cu adev\u0103rat necesare \u00een aceste vremuri incerte.&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>\u0218tia\u021bi c\u0103, pentru multe persoane care sufer\u0103 de depresie \u00een \u00eentreaga lume, o parte substan\u021bial\u0103 dintre ele nu r\u0103spund la niciun tratament?<\/p>","protected":false},"author":1,"featured_media":14815,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"topics":[],"class_list":["post-14811","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts\/14811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/comments?post=14811"}],"version-history":[{"count":1,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts\/14811\/revisions"}],"predecessor-version":[{"id":123822,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts\/14811\/revisions\/123822"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/media\/14815"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/media?parent=14811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/categories?post=14811"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/tags?post=14811"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/topics?post=14811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}