{"id":14862,"date":"2020-10-17T16:58:00","date_gmt":"2020-10-17T16:58:00","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=14862"},"modified":"2023-05-11T14:16:00","modified_gmt":"2023-05-11T12:16:00","slug":"benzile-de-psilocibina-care-schimba-medicina","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/ro\/blog\/the-psilocybin-strips-changing-medicine\/","title":{"rendered":"Benzi de psilocibin\u0103 care schimb\u0103 medicina"},"content":{"rendered":"<h2 class=\"wp-block-heading\" id=\"h-the-psilocybin-strips-changing-medicine\"><em>Benzi de psilocibin\u0103 care schimb\u0103 medicina<\/em><\/h2>\n\n\n\n\n\n<p>Exist\u0103, de asemenea, o avalan\u0219\u0103 de universit\u0103\u021bi uria\u0219e \u0219i respectate care \u00ee\u0219i lanseaz\u0103 propriile centre de cercetare psihedelic\u0103, \u0219i anume Centrul pentru \u0218tiin\u021ba Psihedelicilor de la UC Berkeley, luna trecut\u0103.<strong>,<\/strong> Johns Hopkins \u00een 2019, iar NYU Langone Health a deschis \u00een 2019. <a aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\" href=\"https:\/\/cheddar.com\/media\/mindmed-psychedelics-nyu-langone-nasdaq-uplist\" target=\"_blank\" rel=\"noreferrer noopener\">divizia viitoare<\/a>, toate \u00een c\u0103utarea urm\u0103toarei mari descoperiri a medicinei psihedelice.<\/p>\n\n\n\n<p>Ve\u0219ti incitante, nu? A\u0219tepta\u021bi p\u00e2n\u0103 c\u00e2nd ve\u021bi auzi despre <a aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\" href=\"https:\/\/www.cybin.com\/cybin-corp-and-intelgenx-corp-enter-into-feasibility-agreement-for-fast-acting-orally-dissolving-psilocybin-film\/\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Cybin's <\/em>nou concasor<\/a>: o band\u0103 de film cu doze mari de psilocibin\u0103 care se tope\u0219te \u00een gur\u0103... la propriu. Acestea sunt benzile de psilocibin\u0103 care schimb\u0103 medicina...<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-oral-vs-sublingual-intake-of-psilocybin\"><strong> <\/strong><em>Administrarea oral\u0103 vs. sublingual\u0103 a psilocibinei <\/em><\/h2>\n\n\n\n<figure><img decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/2020\/10\/mouths-scaled-1.jpg\" alt=\"\" \/><figcaption><mark><em>(Pentru imagine, multumim: site-ul IntelGenX)<\/em><\/mark><\/figcaption><\/figure>\n\n\n\n<p>Cybin Corporation a \u00eencheiat un parteneriat cu <a aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\" href=\"https:\/\/www.intelgenx.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">IntelGenx<\/a> <strong>,<\/strong> o companie de tehnologie de administrare oral\u0103 a medicamentelor, pentru a face <em>Psilotonin\u2122<\/em> - primele benzi cu dizolvare rapid\u0103 cu psilocibin\u0103 de calitate farmaceutic\u0103. Benzile de 25 mg de psilocibin\u0103 sunt concepute pentru a fi sublinguale. <em>(sau plasate \"sub limb\u0103\")<\/em> spre deosebire de majoritatea studiilor clinice \u0219i a terapiilor psihedelice care utilizeaz\u0103 capsule.<\/p>\n\n\n\n<p>Prin intermediul c\u0103ii standard de administrare, psilocibina trebuie s\u0103 treac\u0103 prin sistemul digestiv pentru a se putea transforma \u00een psilocin\u0103 - compusul bioactiv care ac\u021bioneaz\u0103 asupra creierului. <em><a aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\" href=\"https:\/\/www.hormone.org\/your-health-and-hormones\/glands-and-hormones-a-to-z\/hormones\/serotonin\" target=\"_blank\" rel=\"noreferrer noopener\">\"hormonul fericirii\"<\/a><\/em><strong><a aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\" href=\"https:\/\/www.hormone.org\/your-health-and-hormones\/glands-and-hormones-a-to-z\/hormones\/serotonin\" target=\"_blank\" rel=\"noreferrer noopener\"> <\/a><\/strong> receptoare.<\/p>\n\n\n\n<p><em>(Not\u0103: Acesta este motivul pentru care, de obicei, dureaz\u0103 cel pu\u021bin 30 de minute pentru ca o c\u0103l\u0103torie s\u0103 se materializeze. Acum \u0219tii!)<\/em><\/p>\n\n\n\n<p>De asemenea, merit\u0103 men\u021bionat faptul c\u0103 50-60% dintr-o doz\u0103 de 25 mg se pierde atunci c\u00e2nd este administrat\u0103 pe cale oral\u0103, ceea ce \u00eenseamn\u0103 c\u0103 nu intr\u0103 niciodat\u0103 \u00een fluxul sanguin... sau ajunge la creier, dac\u0103 este cazul.  Acest lucru se datoreaz\u0103 faptului c\u0103 o mare parte din psilocin\u0103 este metabolizat\u0103 mai \u00eent\u00e2i \u00een ficat - nu \u00een gur\u0103 sau \u00een stomac.<\/p>\n\n\n\n<p>Pe de alt\u0103 parte, atunci c\u00e2nd o band\u0103 de film de psilocibin\u0103 se tope\u0219te sub limb\u0103, aceasta poate s\u0103ri peste traseul obi\u0219nuit pe care \u00eel parcurge pentru a fi \"biodisponibil\u0103\". <em>(sau absorbite \u0219i utilizate de organism),<\/em> care intr\u0103 imediat \u00een fluxul sanguin.<\/p>\n\n\n\n<p>Directorul medical al Cybin, Jukka Karjalainen, a declarat:<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><p> <em>\"\u00cen cazul doz\u0103rii cu film oral, biodisponibilitatea ajunge la 100%. Doza care se administreaz\u0103 este doza disponibil\u0103 pentru efectul clinic.\" <\/em><\/p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-is-your-gut-required-for-psilocybin-s-full-effect\"> <em>Este necesar intestinul t\u0103u pentru efectul deplin al psilocibinei? <\/em><\/h2>\n\n\n\n<p>A\u0219tepta\u021bi. Dac\u0103 o doz\u0103 administrat\u0103 printr-o pelicul\u0103 cu dizolvare oral\u0103 este doar o frac\u021biune din cea necesar\u0103 pentru capsule, atunci ce rol mai joac\u0103 intestinul t\u0103u c\u00e2nd vine vorba de psilocibin\u0103? Dr. Alan Davis, profesor asistent adjunct al Unit\u0103\u021bii de Cercetare Psihedelic\u0103 a Universit\u0103\u021bii Johns Hopkins, ofer\u0103 c\u00e2teva informa\u021bii:<\/p>\n\n\n\n<p class=\"has-medium-font-size\"><p> <em>\"Exist\u0103, de asemenea, unele semne de \u00eentrebare cu privire la importan\u021ba intestinului \u00een perturbarea proceselor de s\u0103n\u0103tate mintal\u0103.\"<\/em><\/p><\/p>\n\n\n\n<p>Dr. Davis a mai spus c\u0103 microbiomul intestinal - sau totalitatea bacteriilor, protozoarelor \u0219i ciupercilor prezente \u00een interiorul t\u0103u - poate juca un rol \u00een s\u0103n\u0103tatea mintal\u0103. Acest lucru se datoreaz\u0103 \u00een mare parte abunden\u021bei de transportatori de serotonin\u0103 <em>(care aduce psilocin\u0103 \u00een creier)<\/em> \u00een interiorul intestinului.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-this-could-mean-for-patients\"><em>Ce ar putea \u00eensemna acest lucru pentru pacien\u021bi<\/em><\/h2>\n\n\n\n<p>IntelGenX's wafer-thin <a aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\" href=\"https:\/\/www.intelgenx.com\/technology\/versafilm.html\" target=\"_blank\" rel=\"noreferrer noopener\">Tehnologia VersaFilm<\/a> - care permite o dezintegrare rapid\u0103 f\u0103r\u0103 a fi nevoie de ap\u0103 - are o mul\u021bime de implica\u021bii nu doar pentru psihedelice, ci \u0219i pentru medicin\u0103 \u00een general.<\/p>\n\n\n\n<p>O platform\u0103 versatil\u0103 de administrare a medicamentelor, cum ar fi benzile de film, ar putea oferi pacien\u021bilor o serie de alte beneficii poten\u021biale, cum ar fi:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Absorb\u021bie bucal\u0103 mai rapid\u0103<\/strong> <em>(care se refer\u0103 la momentul \u00een care un medicament este plasat \u00eentre gingii \u0219i obraz.)<\/em><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Absorb\u021bie sublingual\u0103 mai rapid\u0103<\/strong> <em>(\"sub limb\u0103<\/em>.&#8221;<em>)<\/em><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Debut mai rapid al ac\u021biunii + biodisponibilitate crescut\u0103<\/strong>.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Mai mult confort pentru pacien\u021bi<\/strong> datorit\u0103 dimensiunii sale mici \u0219i sub\u021biri.<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p>De asemenea, prin omiterea metabolismului de prim\u0103 trecere, <em>\"ceea ce dozezi este ceea ce prime\u0219ti\"<\/em> - deci exist\u0103 <strong>mai multe medicamente pentru a fi absorbite \u00een fluxul sanguin<\/strong> <em>(spre deosebire de capsule)<\/em>.<\/p>\n\n\n\n<p>Benzile de film sunt, de asemenea, perfecte pentru pacien\u021bii care au probleme de \u00eenghi\u021bire, care se tem s\u0103 se \u00eenece sau care sunt cuprin\u0219i de grea\u021b\u0103 de la<strong> chimioterapie<\/strong> sau <strong>radioterapie<\/strong>.<\/p>\n\n\n\n<p>Exist\u0103, de asemenea, poten\u021bialul pentru op\u021biuni nelimitate de arom\u0103, deoarece \u00eentreaga cantitate de aport se produce \u00een papilele gustative. <em>(Benzi de film cu arom\u0103 de ciocolat\u0103 cu ment\u0103? Cybin ar fi nebun s\u0103 nu experimenteze)<\/em>.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-clinical-trials-in-jamaica\"><em>Studii clinice \u00een Jamaica<\/em><\/h2>\n\n\n\n<p>Cybin inten\u021bioneaz\u0103 s\u0103 efectueze testele \u00een Jamaica, unul dintre locurile norocoase \u00een care psilocibina este legal\u0103, cu 2 faze \u00een total: Phase2A \u0219i Phase2B. Faza 2A ar trebui s\u0103 afle exact c\u00e2te miligrame de psilocibin\u0103 pur\u0103 <em>(administrat sublingual prin benzi de film)<\/em> sunt echivalente cu doza standard de 25 mg \u00eentr-o capsul\u0103. Dozele de 1, 3, 5 \u0219i 7 mg vor fi testate \u00een mod specific. Faza 2B va testa apoi doza sublingual\u0103 corect\u0103 fa\u021b\u0103 de placebo la 120 de participan\u021bi cu tulburare depresiv\u0103 major\u0103 <em>(MDD)<\/em>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-easier-times-ahead-for-patients-and-their-caregivers\"><em> Se anun\u021b\u0103 vremuri mai u\u0219oare pentru pacien\u021bi \u0219i \u00eengrijitorii lor? <\/em><\/h2>\n\n\n\n<p>U\u0219urin\u021ba, comoditatea \u0219i confortul.&nbsp;<\/p>\n\n\n\n<p>Acestea sunt lucruri pe care uneori le consider\u0103m de la sine \u00een\u021belese. Ne bucur\u0103m de pl\u0103cerile simple ale vie\u021bii, cum ar fi un sfert de kilogram cu br\u00e2nz\u0103 sau o halb\u0103 de bere rece ca ghea\u021ba. Avem parte de luxul timpului, un lux pe care pacien\u021bii din <a aria-label=\"nedefinit (se deschide \u00eentr-o fil\u0103 nou\u0103)\" href=\"https:\/\/www.who.int\/cancer\/palliative\/definition\/en\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u00eengrijire paliativ\u0103<\/a> nu poate fi permis\u0103.<\/p>\n\n\n\n<p>Iat\u0103 de ce este at\u00e2t de important ca oamenii de \u0219tiin\u021b\u0103 s\u0103 inoveze, pentru cercetarea psihedelic\u0103 <em>(sau doar cercetarea medical\u0103, \u00een general)<\/em> s\u0103 ne str\u0103duim s\u0103 facem ca experien\u021bele acestor pacien\u021bi s\u0103 fie mai suportabile.  Lucruri simple, cum ar fi scurtarea timpului de a\u0219teptare, ar putea salva secunde pre\u021bioase din rutina zilnic\u0103 a unui pacient - care ar trebui s\u0103 fie petrecute \u00een confort.<\/p>\n\n\n\n<p>Aceast\u0103 nou\u0103 tehnologie a benzilor de psilocibin\u0103 este un alt pas spre legitimitate \u0219i eficien\u021b\u0103 \u00een tratamentul psihedelic ... aceasta va juca un rol important \u00een medicina viitorului, \u00een special pentru \u00eengrijirea la sf\u00e2r\u0219itul vie\u021bii.&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Promisiunea psihedelicelor str\u0103luce\u0219te mai puternic cu fiecare descoperire din cercetare. S\u0103 lu\u0103m, de exemplu, terapia cu MDMA pentru pacien\u021bii cu PTSD sau microdozarea psilocibinei pentru combaterea depresiei \u0219i a anxiet\u0103\u021bii. \u0218i v\u0103 aminti\u021bi c\u00e2nd Canada a permis utilizarea psilocibinei pentru \u00eengrijirea la sf\u00e2r\u0219itul vie\u021bii?\u00a0<\/p>","protected":false},"author":1,"featured_media":14865,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[69],"tags":[],"topics":[],"class_list":["post-14862","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-culture"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts\/14862","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/comments?post=14862"}],"version-history":[{"count":1,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts\/14862\/revisions"}],"predecessor-version":[{"id":123816,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts\/14862\/revisions\/123816"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/media\/14865"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/media?parent=14862"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/categories?post=14862"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/tags?post=14862"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/topics?post=14862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}