{"id":47545,"date":"2022-02-22T11:09:07","date_gmt":"2022-02-22T10:09:07","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=47545"},"modified":"2023-05-10T08:03:45","modified_gmt":"2023-05-10T06:03:45","slug":"studiile-arata-ca-ssris-nu-opresc-efectul-psilocibinei","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/ro\/blog\/studies-show-ssris-do-not-stop-psilocybin-working\/","title":{"rendered":"Studiile arat\u0103 c\u0103 SSRI-urile nu opresc Psilocybinul de lucru"},"content":{"rendered":"<p><\/p>\n\n<p style=\"font-size: 27px\"><strong>\u00a0Ridicat\u0103 la \u00een\u0103l\u021bimea studiilor \u0219i cercet\u0103rilor \u0219tiin\u021bifice, aceast\u0103 substan\u021b\u0103, care \u00eenainte era pus\u0103 laolalt\u0103 cu droguri periculoase precum heroina \u0219i cocaina, are parte de o schimbare de imagine mult a\u0219teptat\u0103.\u00a0<\/strong><\/p>\n<p>\u00a0<\/p>\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<figure><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/Magic-mushrooms-with-SSRIs.jpg\" alt=\"\" width=\"840\" height=\"472\"><p><\/p>\n<figcaption><mark><em>via Creative Commons<\/em><\/mark><\/figcaption>\n<\/figure>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-a-bitter-irony-for-those-with-depression\">O ironie amar\u0103 pentru cei care sufer\u0103 de depresie<\/h2>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Nu poate veni destul de repede. Nu numai c\u0103 este o nebunie c\u0103 o substan\u021b\u0103 clasificat\u0103<a href=\"https:\/\/www.sciencealert.com\/researchers-rank-recreational-drugs-based-on-how-dangerous-they-are\" target=\"_blank\" rel=\"noreferrer noopener\"> cel mai pu\u021bin periculos drog recrea\u021bional<\/a><em> (cu<\/em><strong><em> foarte lega<\/em><\/strong><em>l alcool cu cel pu\u021bin 10x mai multe \u0219anse de a te b\u0103ga \u00een \u00eencurc\u0103tur\u0103!)<\/em> este \u00eenc\u0103 interzis\u0103, exist\u0103 milioane de oameni din \u00eentreaga lume care ar putea beneficia de magia psilocibinei.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>P\u00e2n\u0103 \u00een prezent, acest compus minune a fost v\u0103zut pentru a trata afec\u021biuni de la <a href=\"https:\/\/www.wholecelium.com\/ro\/blog\/pot-psihedelicele-sa-trateze-bolile-mintale-pentru-totdeauna\/\">depresie<\/a>,&nbsp;<a href=\"https:\/\/www.wholecelium.com\/ro\/blog\/ciupercile-ajuta-soldatii-sa-lupte-impotriva-ptsd\/\" target=\"_blank\" rel=\"noopener\">PTSD<\/a>, anxietate,&nbsp;<a href=\"https:\/\/www.wholecelium.com\/ro\/blog\/renuntarea-la-fumat-cu-ciuperci-magice\/\" target=\"_blank\" rel=\"noopener\">dependen\u021b\u0103<\/a>, \u0219i tulbur\u0103ri de alimenta\u021bie. Este \u00eentr-adev\u0103r foarte interesant. Cu toate acestea, p\u00e2n\u0103 de cur\u00e2nd a existat <strong>ironie amar\u0103<\/strong> ata\u0219at acestei pove\u0219ti de succes \u00een plin\u0103 expansiune. Pentru o lung\u0103 perioad\u0103 de timp, se \u0219tia c\u0103 efectele dorite ale psilocibinei ar fi atenuate de utilizarea medicamentelor antidepresive \u0219i anxioase tradi\u021bionale. Accentul principal a fost pus pe <em>Inhibitori selectivi ai recapt\u0103rii serotoninei<\/em> sau \"SSRI\".&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/SSRIs-pills.jpg\" alt=\"\" width=\"840\" height=\"436\"><p><\/p>\n<figcaption><em><mark>Fotografie de Nastya Dulhiier pe Unsplash<\/mark><\/em><\/figcaption>\n<\/figure>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>G\u00e2nde\u0219te-te la asta... cei care \u00ee\u0219i doresc cel mai mult ajutorul pe care \u00eel ofer\u0103 psilocibina sunt \u00eempiedica\u021bi de medicamentele pe care le iau \u00een prezent. Vorbim despre nedreptate!<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-the-problems-with-ssris\">Problemele cu SSRIs<\/h2>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>\u0218i exist\u0103 multe motive pentru care cineva ar putea dori s\u0103 renun\u021be la medicamentele farmaceutice tradi\u021bionale. Bine\u00een\u021beles c\u0103 acestea func\u021bioneaz\u0103 pentru mul\u021bi oameni. Dar pentru mul\u021bi oameni nu func\u021bioneaz\u0103. S-ar putea ca acestea s\u0103 nu aib\u0103 niciun efect sau foarte pu\u021bin efect. C\u0103 ele creeaz\u0103 o amor\u021beal\u0103 emo\u021bional\u0103 care nu poate fi suportat\u0103. C\u0103 numeroasele efecte secundare sunt prea mult de suportat. Sau, chiar c\u0103 utilizatorul nu dore\u0219te s\u0103 introduc\u0103 \u00een corpul s\u0103u substan\u021be chimice nenaturale.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Oric\u00e2t de mult s-ar lupta unii dintre utilizatorii lor cu ele, pentru mul\u021bi dintre ei este vorba fie de medicamente, fie de a suferi de cea mai paralizant\u0103 versiune a depresiei sau anxiet\u0103\u021bii lor. Acest lucru le pune \u00een pericol propria lor siguran\u021b\u0103, precum \u0219i rela\u021biile cu cei dragi \u0219i angajamentele profesionale.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/gadiel-lazcano-ulPAVuxITEw-unsplash.jpg\" alt=\"\" width=\"841\" height=\"416\"><p><\/p>\n<figcaption><mark><em>Fotografie de Gadiel Lazcano pe Unsplash<\/em><\/mark><\/figcaption>\n<\/figure>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>At\u00e2t psilocibina, c\u00e2t \u0219i SSRI-urile interac\u021bioneaz\u0103 cu neurotransmi\u021b\u0103torul <a href=\"https:\/\/en.wikipedia.org\/wiki\/Serotonin\" target=\"_blank\" rel=\"noreferrer noopener\">serotonin\u0103<\/a>, dar \u00een moduri foarte diferite. SSRI prind serotonina \u00een creier \u0219i pot adesea s\u0103 atenueze r\u0103spunsul emo\u021bional. \u00cen schimb, psilocibina se leag\u0103 \u0219i stimuleaz\u0103 receptorii, sporind de fapt conexiunea emo\u021bional\u0103.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Anterior, se recomanda ca un utilizator de SSRI s\u0103 se dezintoxice \u00eenainte de a \u00eencepe s\u0103 ia psilocibin\u0103. Pentru mul\u021bi utilizatori, acest lucru reprezint\u0103 o problem\u0103, deoarece ace\u0219tia vor experimenta un sevraj fizic \u0219i psihic substan\u021bial, precum \u0219i o revenire a simptomelor afec\u021biunii lor. Este mult de cerut, mai ales atunci c\u00e2nd tratamentul pe care \u00eel dori\u021bi este ilegal sau greu de accesat \u00een multe locuri.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-new-studies-show-you-can-combine-ssris-and-psilocybin\">Noi studii arat\u0103 c\u0103 pute\u021bi combina SSRI \u0219i Psilocybinul<\/h2>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>A\u0219adar, cu o emo\u021bie suprem\u0103 putem raporta c\u0103 dou\u0103 studii recente, publicate la c\u00e2teva s\u0103pt\u0103m\u00e2ni distan\u021b\u0103 unul de cel\u0103lalt, la sf\u00e2r\u0219itul anului 2021, indic\u0103 faptul c\u0103 acest lucru este de fapt <em>nu <\/em>cazul. Pute\u021bi combina SSRI \u0219i psilocibina f\u0103r\u0103 efecte negative asupra ambelor substan\u021be!&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>\u00cen primul r\u00e2nd de c\u0103tre o companie de biotehnologie<a href=\"https:\/\/mindmed.co\/\" target=\"_blank\" rel=\"noreferrer noopener\"> MindMed<\/a>, care \u00een noiembrie 2021 a publicat date care au ar\u0103tat cum interac\u021bioneaz\u0103 psilocibina \u0219i SSRI-urile la om. Studiul, realizat de Spitalul Universitar din Basel, a constatat c\u0103 participan\u021bii care foloseau SSRI <em>escitalopram<\/em> au sim\u021bit totu\u0219i efectele pozitive ale psilocibinei asupra st\u0103rii de spirit. Ace\u0219tia au avut, de asemenea, un poten\u021bial redus pentru efectele negative pe care psilocibina le poate provoca, cum ar fi anxietatea, \u00een compara\u021bie cu grupul placebo.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<figure><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/jesse-orrico-rmWtVQN5RzU-unsplash.jpg\" alt=\"\" width=\"839\" height=\"556\"><p><\/p>\n<figcaption><mark><em>Fotografie de jesse orrico pe Unsplash<\/em><\/mark><\/figcaption>\n<\/figure>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>\u00cen cadrul studiului, unor participan\u021bi li s-au administrat fie 10 mg de escitalopram zilnic timp de \u0219apte zile, apoi 20 mg zilnic \u00een urm\u0103toarele \u0219apte zile, inclusiv \u00een ziua administr\u0103rii psilocibinei. Ceilal\u021bi, dou\u0103 s\u0103pt\u0103m\u00e2ni de un placebo p\u00e2n\u0103 la administrarea de psilocibin\u0103.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-answering-key-questions\">R\u0103spunsuri la \u00eentreb\u0103ri cheie<\/h2>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Cercet\u0103torul principal al studiului, Dr. Matthias Liechti, a explicat \u00eentreb\u0103rile la care sper\u0103 s\u0103 r\u0103spund\u0103 prin cercetarea lor:<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p><em>\"\u00cen primul r\u00e2nd, din motive de siguran\u021b\u0103, ar trebui ca un pacient s\u0103 nu mai foloseasc\u0103 antidepresive \u00eenainte de a primi psilocibin\u0103? \u00cen al doilea r\u00e2nd, dac\u0103 nu exist\u0103 niciun risc de siguran\u021b\u0103, va reduce antidepresivul r\u0103spunsul pacientului la psilocibin\u0103?\"<\/em><\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>\u0218i au fost \u00een m\u0103sur\u0103 s\u0103 le r\u0103spund\u0103:<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p><em>\"Aceste rezultate indic\u0103 faptul c\u0103 psilocibina poate fi dozat\u0103 \u00een timpul tratamentului cu escitalopram f\u0103r\u0103 un impact aparent asupra efectului psilocibinei. Astfel, studiul r\u0103spunde la prima \u00eentrebare \u0219i ofer\u0103 o indica\u021bie pozitiv\u0103 pentru cea de-a doua.\" (Dr. Liechti)&nbsp;<\/em><\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Un prim pas bun, cu un stimulent urgent pentru a face mai multe studii, dup\u0103 cum a subliniat Dr. Miri Halperin Wernli, pre\u0219edintele executiv al MindMed;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p><em>\"Dac\u0103 rezultatele sunt confirmate \u00een studii ulterioare, cu alte substan\u021be \u0219i la pacien\u021bi \u0219i nu la persoane s\u0103n\u0103toase, s-ar putea s\u0103 nu mai fie nevoie de \u00eentreruperea tratamentului cu psilocibin\u0103,\"&nbsp;<\/em><\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-compass-pathways-find-the-same-result\">Compass Pathways a g\u0103sit acela\u0219i rezultat<\/h2>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Oh, \u0219i nu \u0219tii? \u00cen c\u00e2teva s\u0103pt\u0103m\u00e2ni <a href=\"https:\/\/compasspathways.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">C\u0103ile de acces Compass<\/a> au publicat propriile date, cu mai multe dovezi...<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>\u00cen studiul Compass Pathways s-au constatat rezultate comparabile la participan\u021bii care \u00eenc\u0103 mai luau un regim de SSRI \u0219i la cei care \u00ee\u0219i \u00eentrerupseser\u0103 regimul \u00eenainte de studiu, c\u00e2nd li s-a administrat <em>COMP360.  COMP360 <\/em>este o nou\u0103 extrac\u021bie de psilocibin\u0103 creat\u0103 de Compass Pathways special pentru uz terapeutic.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Directorul medical al Compass Pathways, Guy Goodwin, a declarat:<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p><em>\"Rezultatele acestui studiu contest\u0103 credin\u021ba larg r\u0103sp\u00e2ndit\u0103 c\u0103 utilizarea medicamentelor SSRI \u00eempreun\u0103 cu psilocibina ar putea interfera cu efectul terapeutic al psilocibinei. Constat\u0103rile noastre ofer\u0103 un semnal puternic c\u0103 terapia cu psilocibin\u0103 COMP360 ar putea fi un tratament adjuvant la antidepresivele SSRI, precum \u0219i o monoterapie.\"<\/em><\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>A<em> <\/em>\"monoterapie\" este un <strong>un medicament <\/strong>tratament. Deci, ceea ce el <em>spun\u00e2nd <\/em>este c\u0103 psilocibina ar putea fi folosit\u0103 at\u00e2t ca tratament singular <em>(a\u0219a cum \u0219tiam)<\/em> <em><strong>\u0219i<\/strong> <\/em>\u00eempreun\u0103 cu SSRI.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-magic-mushroom-myth-busting\">Mitul ciupercilor magice: distrugerea mitului!<\/h2>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Uf! Se \u00eent\u00e2mpl\u0103 o adev\u0103rat\u0103 distrugere de mituri. Este o veste grozav\u0103 pentru cei care iau \u00een prezent SSRI \u0219i care doresc s\u0103 urmeze tratamente cu psilocibin\u0103 - adesea cei care au cea mai mare nevoie de ele.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Urm\u0103ri\u021bi acest spa\u021biu pentru mai multe rezultate pozitive!<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<figure><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/19.png\" alt=\"\" width=\"341\" height=\"341\"><\/figure>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p><em>\u0218i \u00eentre timp, nu uita\u021bi s\u0103 vorbi\u021bi \u00eentotdeauna cu medicul dumneavoastr\u0103 dac\u0103 inten\u021biona\u021bi s\u0103 face\u021bi o schimbare \u00een ceea ce prive\u0219te medicamentele sau rutina de wellness.<\/em>.<\/p>\n<p>\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>\u00cen ultimii doi ani, psilocibina - ingredientul activ din ciupercile magice \u0219i trufe - a fost prezentat\u0103 ca fiind marea speran\u021b\u0103 \u00een tratamentul s\u0103n\u0103t\u0103\u021bii mintale.<\/p>","protected":false},"author":4,"featured_media":47646,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88],"tags":[],"topics":[],"class_list":["post-47545","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts\/47545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/comments?post=47545"}],"version-history":[{"count":2,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts\/47545\/revisions"}],"predecessor-version":[{"id":123347,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/posts\/47545\/revisions\/123347"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/media\/47646"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/media?parent=47545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/categories?post=47545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/tags?post=47545"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/ro\/wp-json\/wp\/v2\/topics?post=47545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}