{"id":13908,"date":"2020-07-23T15:36:18","date_gmt":"2020-07-23T15:36:18","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=13908"},"modified":"2023-05-11T17:56:08","modified_gmt":"2023-05-11T15:56:08","slug":"preco-je-efekt-okolia-dolezity","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/sk\/blog\/why-the-entourage-effect-matters\/","title":{"rendered":"Pre\u010do je efekt Entourage d\u00f4le\u017eit\u00fd"},"content":{"rendered":"<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-what-is-the-entourage-effect\"><em>\u010co je to Entourage Effect?<\/em><\/h2>\n\n\n\n<p>Nov\u00fd v\u00fdskum uk\u00e1zal, \u017ee v magick\u00fdch hub\u00e1ch je ove\u013ea viac \u00fa\u010dinn\u00fdch l\u00e1tok ako len psilocyb\u00edn. Okrem toho je ve\u013emi pravdepodobn\u00e9, \u017ee zohr\u00e1vaj\u00fa d\u00f4le\u017eit\u00fa \u00falohu pri psychedelick\u00fdch \u00fa\u010dinkoch h\u00fab. Ide o tzv. sprievodn\u00fd \u00fa\u010dinok. Je v\u0161eobecne zn\u00e1me, \u017ee existuje s <a aria-label=\"undefined (otvor\u00ed sa v novej karte)\" href=\"https:\/\/www.leafly.com\/news\/cannabis-101\/cannabis-entourage-effect-why-thc-and-cbd-only-medicines-arent-g\" target=\"_blank\" rel=\"noreferrer noopener\">konope<\/a>. Skor\u0161\u00ed v\u00fdskum vlastnost\u00ed konope sa zameriaval v\u00fdlu\u010dne na THC.  \u010coskoro v\u0161ak \u0161t\u00fadie zistili, \u017ee ide o cel\u00fa s\u00fastavu zl\u00fa\u010den\u00edn, ktor\u00e9 spolo\u010dne vytv\u00e1raj\u00fa jej \u00fa\u010dinok. V s\u00fa\u010dasnosti sa dospelo k z\u00e1veru, \u017ee CBD je okrem in\u00fdch zl\u00fa\u010den\u00edn nevyhnutn\u00fd na to, aby konope dosiahlo svoj pln\u00fd potenci\u00e1l. Zauj\u00edmav\u00e9 je, \u017ee v pr\u00edpade magick\u00fdch h\u00fab je to nie\u010do, \u010do e\u0161te len objavujeme. Zd\u00e1 sa, \u017ee psychoakt\u00edvne zl\u00fa\u010deniny sa radi dr\u017eia v skupin\u00e1ch. <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-twin-troublemakers\"><em>Dvoji\u010dky Troublemakers<\/em><\/h2>\n\n\n\n<p>Tak\u017ee, <a aria-label=\"undefined (otvor\u00ed sa v novej karte)\" href=\"https:\/\/www.wholecelium.com\/sk\/wiki\/mykologia\/what-is-psilocybin\/\" target=\"_blank\" rel=\"noreferrer noopener\">psilocyb\u00edn<\/a> je zl\u00fa\u010denina, ktor\u00e1 zvy\u010dajne pri\u0165ahuje najv\u00e4\u010d\u0161iu pozornos\u0165. Magick\u00e9 huby obsahuj\u00fa v z\u00e1vislosti od druhu 0,2-1,8% psilocyb\u00ednu v su\u0161ine. Po konzum\u00e1cii sa psilocyb\u00edn r\u00fdchlo men\u00ed na svoj akt\u00edvny metabolit, psiloc\u00edn. Psilocyb\u00edn aj psiloc\u00edn sa via\u017eu na seroton\u00ednov\u00e9 receptory. Tak\u017ee tieto dvoj\u010dat\u00e1 s\u00fa zodpovedn\u00e9 za v\u00e4\u010d\u0161inu psychedelick\u00fdch \u00fa\u010dinkov magick\u00fdch h\u00fab.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-don-t-underestimate-baeocystin\"><em>Nepodce\u0148ujte baeocyst\u00edn!<\/em><\/h2>\n\n\n\n<p>Psilocy\u00edn tvor\u00ed pribli\u017ene 0,02-0,6% suchej hmotnosti magick\u00fdch h\u00fab v z\u00e1vislosti od druhu. Potom e\u0161te menej zn\u00e1my baeocyst\u00edn je \u010fal\u0161ou najroz\u0161\u00edrenej\u0161ou molekulou - v s\u00fa\u010dasnosti v\u0161ak o \u0148om ve\u013ea nevieme. Podobne ako psiloc\u00edn je to \u010fal\u0161\u00ed deriv\u00e1t psilocyb\u00ednu, tak\u017ee pravdepodobne m\u00e1 tie\u017e nejak\u00fd psychoakt\u00edvny \u00fa\u010dinok. Vedec Jochen Gartz op\u00edsal, ako mu mal\u00e1 d\u00e1vka 4 mg poskytla <em>\"jemn\u00fd halucinog\u00e9nny z\u00e1\u017eitok\".<\/em> <em> <\/em>Baeocyst\u00edn je v su\u0161en\u00fdch magick\u00fdch hub\u00e1ch pr\u00edtomn\u00fd v mno\u017estve pribli\u017ene 0,005-0,36% v z\u00e1vislosti od druhu.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-enter-the-beta-carbolines\"><em>Vst\u00fapte do Beta-karbol\u00ednov!<\/em><\/h2>\n\n\n\n<p>Pr\u00edtomnos\u0165 beta-karbol\u00ednov bola ned\u00e1vno zisten\u00e1 aj v magick\u00fdch hub\u00e1ch. Beta-karbol\u00edny s\u00fa skupinou alkaloidov, ktor\u00e9 sa nach\u00e1dzaj\u00fa v mnoh\u00fdch druhoch rastl\u00edn. Najm\u00e4 v lie\u010divej rastline <a aria-label=\"undefined (otvor\u00ed sa v novej karte)\" href=\"https:\/\/en.wikipedia.org\/wiki\/Ayahuasca\" target=\"_blank\" rel=\"noreferrer noopener\">ayahuasca<\/a> obsahuje beta-karbol\u00edny<em> harmin, harmal\u00edn<\/em>a <em>tetrahydroharm\u00edn<\/em>. Tie br\u00e1nia enz\u00fdmu monoaminooxid\u00e1ze (MAO), ktor\u00fd sa nach\u00e1dza v na\u0161ich \u017eal\u00fadkoch. Ajahuaskov\u00e9 n\u00e1poje obsahuj\u00fa psychedelick\u00fa molekulu <a aria-label=\"undefined (otvor\u00ed sa v novej karte)\" href=\"https:\/\/en.wikipedia.org\/wiki\/N,N-Dimethyltryptamine\" target=\"_blank\" rel=\"noreferrer noopener\">DMT<\/a>, ktor\u00fd sa zvy\u010dajne rozklad\u00e1 enz\u00fdmom MAO. Teraz vid\u00edte, ako do hry vstupuj\u00fa beta-karbol\u00edny; blokuj\u00fa MAO a pom\u00e1haj\u00fa DMT pre\u017ei\u0165 dlh\u0161ie v tele, kde m\u00f4\u017ee ma\u0165 psychoakt\u00edvny \u00fa\u010dinok.<\/p>\n\n\n\n<p>Ned\u00e1vno sa beta-karbol\u00edny <em>harm\u00e1n, harm\u00edn, norharm\u00e1n<\/em> a <em>perlolyrin<\/em> boli zisten\u00e9 u \u0161tyroch druhov h\u00fab. Podobne ako DMT v ayahuasce, aj psiloc\u00edn sa v tele rozklad\u00e1 pomocou enz\u00fdmu MAO. Teraz v\u0161ak vieme o existencii beta-karbol\u00ednov v magick\u00fdch hub\u00e1ch, z \u010doho m\u00f4\u017eeme usudzova\u0165, \u017ee blokuj\u00fa enz\u00fdm MAO! To predl\u017euje a zvy\u0161uje z\u00e1\u017eitok z psilocyb\u00ednu\/psiloc\u00ednu t\u00fdm, \u017ee zabra\u0148uje jeho odb\u00faravaniu. <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-shrooms-and-ayahuasca-more-similar-than-we-thought\"><em>Huby a ayahuasca - podobnej\u0161ie, ako sme si mysleli! <\/em><\/h2>\n\n\n\n<p>Fascinuj\u00face je, \u017ee objav, \u017ee magick\u00e9 huby obsahuj\u00fa aj beta-karbol\u00edny, by mohol znamena\u0165, \u017ee ayahuasca a magick\u00e9 huby s\u00fa porovnate\u013enej\u0161ie, ako sme si mysleli! Je v\u0161ak v magick\u00fdch hub\u00e1ch dostatok beta-karbol\u00ednov na to, aby mali v\u00fdznamn\u00fd vplyv na z\u00e1\u017eitok u\u017e\u00edvate\u013ea? Nu\u017e, najhojnej\u0161ie zast\u00fapenie beta-karbol\u00ednov zisten\u00fdch v druhoch magick\u00fdch h\u00fab bolo <em>harmane<\/em>, ktor\u00e1 sa pohybovala v rozmedz\u00ed 0,2-21 ug\/g vysu\u0161enej hmotnosti. V n\u00e1pojoch z ayahuascy s\u00fa beta-karbol\u00edny akt\u00edvne v mno\u017estv\u00e1ch a\u017e 0,5 mikrogramu pre priemern\u00e9ho \u010dloveka. To nazna\u010duje, \u017ee mierna d\u00e1vka magickej huby <em>(pribli\u017ene 2 gramy su\u0161en\u00fdch h\u00fab)<\/em> by bolo dostato\u010dn\u00e9 na to, aby tieto beta-karbol\u00edny prispeli k ceste.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-two-studies-stand-out\"><em>Dve \u0161t\u00fadie vystupuj\u00fa do popredia<\/em><\/h2>\n\n\n\n<p>Ke\u010f\u017ee v\u00e4\u010d\u0161ina klinick\u00fdch v\u00fdskumov magick\u00fdch h\u00fab sa s\u00fastredila v\u00fdlu\u010dne na psilocyb\u00edn, nie je ve\u013ea inform\u00e1ci\u00ed, ktor\u00e9 by porovn\u00e1vali subjekt\u00edvne v\u00fdsledky psilocyb\u00ednu v porovnan\u00ed s cel\u00fdmi hubami. Napriek tomu existuj\u00fa dve \u0161t\u00fadie na zvierat\u00e1ch s relevantn\u00fdmi v\u00fdsledkami. V \u0161t\u00fadii z roku 2009 bol my\u0161iam pod\u00e1van\u00fd bu\u010f \u010dist\u00fd psilocyb\u00edn, alebo extrakt z magick\u00fdch h\u00fab. V\u00fdsledky uk\u00e1zali, \u017ee extrakt z magick\u00fdch h\u00fab bol \u00fa\u010dinnej\u0161\u00ed pri zni\u017eovan\u00ed nervov\u00e9ho spr\u00e1vania my\u0161\u00ed ako samotn\u00fd \u010dist\u00fd psilocyb\u00edn.&nbsp;<\/p>\n\n\n\n<p>V inej \u0161t\u00fadii z roku 2015 sa zistilo, \u017ee extrakt z magickej huby bol pribli\u017ene 10-kr\u00e1t \u00fa\u010dinnej\u0161\u00ed pri zmene \u00fazkostn\u00e9ho spr\u00e1vania u my\u0161\u00ed v porovnan\u00ed s \u010dist\u00fdm psiloc\u00ednom. Zd\u00e1 sa, \u017ee to potvrdzuje to, \u010do vedci predpokladali, ke\u010f objavili beta-karbol\u00edny v druhoch magick\u00fdch h\u00fab - \u017ee sprievodn\u00fd efekt v magick\u00fdch hub\u00e1ch m\u00f4\u017ee by\u0165 k\u013e\u00fa\u010dom k ich \u00fa\u010dinnosti. V podstate, ako v\u00e1s u\u010dili v \u0161kole, t\u00edmov\u00e1 pr\u00e1ca zvy\u010dajne prin\u00e1\u0161a lep\u0161\u00ed v\u00fdsledok.<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-strengths-may-vary\"><em> Siln\u00e9 str\u00e1nky sa m\u00f4\u017eu l\u00ed\u0161i\u0165<\/em><\/h2>\n\n\n\n<p>Okrem toho sa ned\u00e1vno zistilo, \u017ee r\u00f4zne \u010dasti tej istej huby m\u00f4\u017eu obsahova\u0165 r\u00f4zne mno\u017estvo psychoakt\u00edvnych l\u00e1tok. U niektor\u00fdch druhov m\u00f4\u017eu klob\u00fa\u010diky obsahova\u0165 dvakr\u00e1t viac psilocyb\u00ednu ako stonky! Podobne aj magick\u00e9 h\u013euzovky obsahuj\u00fa r\u00f4zne mno\u017estv\u00e1 psilocyb\u00ednu v porovnan\u00ed s magick\u00fdmi hubami.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-so-what-does-this-mean\"><em>\u010co to znamen\u00e1?<\/em><\/h2>\n\n\n\n<p>\u010co to teda znamen\u00e1 pre na\u0161e ch\u00e1panie z\u00e1\u017eitku z magick\u00fdch h\u00fab? Vo v\u0161eobecnosti takmer v\u0161etky lek\u00e1rske v\u00fdskumy lie\u010debn\u00e9ho potenci\u00e1lu magick\u00fdch h\u00fab na \u013eu\u010foch vyu\u017e\u00edvali izolovan\u00fd psilocyb\u00edn alebo psiloc\u00edn, a nie extrakt z celej huby.<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-why-the-entourage-effect-matters\"><em>Pre\u010do je efekt Entourage d\u00f4le\u017eit\u00fd<\/em><\/h2>\n\n\n\n<p>Tento nov\u00fd z\u00e1ujem o efekt sprievodu v\u0161ak bude pravdepodobne r\u00e1s\u0165. Mo\u017eno v bud\u00facnosti, ke\u010f bude psychedelick\u00e1 lie\u010dba be\u017en\u00e1, sa rozdiel medzi spotrebite\u013emi, ktor\u00ed si vyber\u00fa doplnok izolovan\u00e9ho psilocyb\u00ednu od farmaceutickej spolo\u010dnosti alebo mikrod\u00e1vku skuto\u010dn\u00fdch h\u00fab alebo h\u013euzoviek, zn\u00ed\u017ei na aspekty, ako je entourage efekt. Pr\u00e1ve preto je sprievodn\u00fd \u00fa\u010dinok d\u00f4le\u017eit\u00fd. <\/p>\n\n\n\n<h2 class=\"wp-block-heading has-pale-cyan-blue-color has-text-color\" id=\"h-real-vs-synthetic\"><em>Skuto\u010dn\u00fd vs. syntetick\u00fd<\/em><\/h2>\n\n\n\n<p>Pri \u010d\u00edtan\u00ed v\u00fdskumnej \u0161t\u00fadie o syntetickom psilocyb\u00edne alebo psiloc\u00edne je preto dobr\u00e9 ma\u0165 tento rozdiel na pam\u00e4ti. A nabud\u00face, ke\u010f budete tripova\u0165 na hub\u00e1ch alebo h\u013euzovk\u00e1ch, nezabudnite oceni\u0165 harm\u00f3niu zl\u00fa\u010den\u00edn, ktor\u00e9 spolo\u010dne vytv\u00e1raj\u00fa v\u00e1\u0161 z\u00e1\u017eitok!<\/p>","protected":false},"excerpt":{"rendered":"<p>Ke\u010f sa hovor\u00ed o magick\u00fdch hub\u00e1ch a v\u00fdskume ich pou\u017eitia, do popredia sa \u010dasto dost\u00e1va \u010dastica psilocyb\u00edn. Psilocyb\u00edn je najroz\u0161\u00edrenej\u0161ou psychedelickou zlo\u017ekou v hub\u00e1ch a magick\u00fdch h\u013euzovk\u00e1ch. V s\u00fa\u010dasnosti sa pri v\u00fdskume \u00fa\u010dinkov magick\u00fdch h\u00fab \u010dasto vyu\u017e\u00edva len t\u00e1to zl\u00fa\u010denina namiesto celej huby. Pre\u010do je teda cel\u00e1 huba lep\u0161ia? Je \u010das dozvedie\u0165 sa, pre\u010do je d\u00f4le\u017eit\u00fd sprievodn\u00fd \u00fa\u010dinok.<\/p>","protected":false},"author":1,"featured_media":13913,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"topics":[],"class_list":["post-13908","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/13908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/comments?post=13908"}],"version-history":[{"count":1,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/13908\/revisions"}],"predecessor-version":[{"id":123871,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/13908\/revisions\/123871"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/media\/13913"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/media?parent=13908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/categories?post=13908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/tags?post=13908"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/topics?post=13908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}