{"id":16583,"date":"2021-01-12T15:10:37","date_gmt":"2021-01-12T15:10:37","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=16583"},"modified":"2023-11-02T16:58:39","modified_gmt":"2023-11-02T15:58:39","slug":"co-je-salvia-salvinorin-a","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/sk\/blog\/what-is-salvia-salvinorin-a\/","title":{"rendered":"\u010co je \u0161alvia (salvinor\u00edn A)?"},"content":{"rendered":"

 <\/strong><\/p>\n\n\n\n

Psychedelik\u00e1 dnes u\u017e\u00edva \u0161irok\u00e9 spektrum spolo\u010dnosti - od mikrod\u00e1vkovanie<\/a> matk\u00e1m, \u013eu\u010fom, ktor\u00ed sa sna\u017eia unikn\u00fa\u0165 z uzamknutia - aj ke\u010f len preto, aby mohli cestova\u0165 vo svojich mysliach. <\/p>\n\n\n\n

Mo\u017eno nie ste kme\u0148ov\u00fd mudrc, ale mo\u017eno sa chcete dozvedie\u0165 nie\u010do viac o \u0161irokej \u0161k\u00e1le l\u00e1tok vyvol\u00e1vaj\u00facich videnie? Tak my sme tu, aby sme v\u00e1m predstavili \u010fal\u0161iu z nich - Miley Cyrus'<\/a> v\u00fdber halucinog\u00e9nov pre t\u00edned\u017eerov - mexick\u00e1 droga Salvinor\u00edn A<\/strong> (pravdepodobne ju pozn\u00e1te pod n\u00e1zvom Salvia).<\/em><\/p>\n\n\n\n

Na Univerzite Johnsa Hopkinsa vedci r\u00f6ntgenovali mozgy t\u00fdch, ktor\u00ed mali vaped Salvinorin A <\/a><\/strong>. Potvrdili, \u017ee salvinor\u00edn A p\u00f4sob\u00ed podobne ako in\u00e9 psychedelik\u00e1, napr\u00edklad psilocyb\u00edn, MDMA a LSD, a to tak, \u017ee nov\u00e9 spojenia v mozgu<\/strong>. <\/p>\n\n\n\n

V\u00fdskumn\u00edci potom zistili, \u010d\u00edm je salvinor\u00edn A tak\u00fd v\u00fdnimo\u010dn\u00fd. Sp\u00fa\u0161\u0165al viac n\u00e1hodn\u00e9<\/strong>, odpojen\u00e9 sign\u00e1ly<\/strong>, ale v pozit\u00edvnom zmysle. <\/p>\n\n\n\n

Nie, \u0161t\u00fadia si to uvedomila. Salvinor\u00edn A nie je len p\u00e1rty droga - je to pr\u00edrodn\u00fd smiechov\u00fd plyn!<\/p>\n\n\n\n

Pr\u00edrodn\u00fd smiechov\u00fd plyn <\/em><\/h2>\n\n\n\n

Salvinor\u00edn A je halucinog\u00e9n, ktor\u00fd sa z\u00edskava z rastliny Salvia divinorum<\/strong>. Poskytuje intenz\u00edvny \"pl\u00e1vaj\u00face\"<\/em> pocity a ak\u00fasi kr\u00e1tkodob\u00fa amn\u00e9ziu - podobne ako pri pou\u017eit\u00ed oxidu dusnat\u00e9ho (alebo \"smiechov\u00e9ho plynu\") u zub\u00e1ra.<\/p>\n\n\n\n

\"Salvinor\u00edn
\u00daplne bo\u017esk\u00e9! Detail z kvetu Salvia divinorum. (S l\u00e1skav\u00fdm dovolen\u00edm: Wikimedia Commons)<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Manoj Doss, PhD.<\/strong>, postdoktorandsk\u00fd v\u00fdskumn\u00fd pracovn\u00edk na Univerzite Johnsa Hopkinsa v oblasti v\u00fdskumu psychedelick\u00fdch l\u00e1tok a vedomia, povedal:<\/p>\n\n\n\n

\"Zd\u00e1 sa, \u017ee salvinor\u00edn A rob\u00ed v\u0161etky veci, o ktor\u00fdch sa vedci domnievaj\u00fa, \u017ee sa dej\u00fa, ke\u010f in\u00e9 psychedelik\u00e1 (ako LSD a psilocyb\u00edn) p\u00f4sobia na mozog. <\/em><\/p>\n\n\n\n

\"Z\u00e1bavn\u00e9 je, \u017ee niektor\u00ed v\u00fdskumn\u00edci sa selekt\u00edvne zameriavaj\u00fa na sie\u0165 \u0161tandardn\u00e9ho re\u017eimu, hoci pr\u00e1ve v nej nenach\u00e1dzaj\u00fa najsilnej\u0161ie \u00fa\u010dinky klasick\u00fdch psychedel\u00edk. <\/em><\/p>\n\n\n\n

\"Naopak, pr\u00e1ve tam sme zistili najsilnej\u0161ie \u00fa\u010dinky salvinor\u00ednu A.\"<\/em><\/p>\n\n\n\n

Mudrc a mudrci <\/em><\/h2>\n\n\n\n

Salvinor\u00edn A je podobne ako psilocyb\u00edn z\u00edskan\u00e9 prirodzen\u00fdm sp\u00f4sobom<\/strong>. Z\u00edskava sa zo \u0161alvie lek\u00e1rskej, Salvia Divinorum. Salvinor\u00edn A m\u00e1 pri u\u017e\u00edvan\u00ed \u013eu\u010fmi r\u00fdchly n\u00e1stup (alebo \u010das, ktor\u00fd je potrebn\u00fd, aby sa \"aktivoval\").<\/em> V\u00fdlet je kr\u00e1tky, ale siln\u00fd... s mimotelov\u00fdmi pocitmi, halucin\u00e1ciami a odtrhnutie od reality. <\/strong><\/p>\n\n\n\n

Na rozdiel od psilocyb\u00ednu a LSD v\u0161ak salvinor\u00edn A neinteraguje s seroton\u00edn-2A<\/strong> - receptor v mozgu, ktor\u00fd riadi u\u010denie, chu\u0165 do jedla a \u010fal\u0161ie akt\u00edvne telesn\u00e9 procesy. V skuto\u010dnosti sa via\u017ee na kappa-opioidn\u00fd receptor, ktor\u00fd zni\u017euje hladinu dopam\u00ednu. To vyvol\u00e1va pocit dysf\u00f3rie (to je opak euf\u00f3rie, tak\u017ee viete, nie je to dobr\u00e9). <\/em>Z tohto d\u00f4vodu mnoh\u00ed \u013eudia hovoria, \u017ee v\u00fdlet so \u0161alviou je \u0165a\u017ek\u00e9<\/em> u\u017e\u00edva\u0165 si.<\/p>\n\n\n\n

Pr\u00edslu\u0161n\u00edk \u010de\u013eade m\u00e4tovit\u00fdch, Salvia divinorum <\/em>je historicky ob\u013e\u00faben\u00fd Mazat\u00e9kovia <\/strong>z Oaxacy v Mexiku. Mazateck\u00ed mudrci u\u017e stovky rokov u\u017e\u00edvaj\u00fa t\u00fato psychoakt\u00edvnu rastlinu pri ritu\u00e1loch. <\/p>\n\n\n\n

Dnes, Salvia divinorum<\/em> sa nach\u00e1dza v\u0161ade v Kalifornii, kde je od roku 2009 leg\u00e1lnym psychedelikom. Miestni obyvatelia chrumkaj\u00fa S. divinorum<\/em> ako quid<\/strong>, \u010do je nie\u010do ako \u017euvac\u00ed tabak. Salvia sa tie\u017e faj\u010d\u00ed v trad\u00edcii tr\u00e1vy, av\u0161ak pre svoje preva\u017ene dezorientuj\u00face a nepr\u00edjemn\u00e9 \u00fa\u010dinky sa nikdy nestala takou roz\u0161\u00edrenou ako in\u00e9 psychedelik\u00e1, ako napr\u00edklad psilocyb\u00edn a LSD. <\/p>\n\n\n\n

Najsilnej\u0161\u00ed pr\u00edrodn\u00fd halucinog\u00e9n<\/em> <\/h2>\n\n\n\n
\"mozog
Salvinor\u00edn A ovplyv\u0148uje oblasti mozgu, ktor\u00e9 s\u00fa najakt\u00edvnej\u0161ie, ke\u010f nie ste du\u0161evne zamestnan\u00ed (zn\u00e1zornen\u00e9 \u010dervenou farbou). Napr\u00edklad, ke\u010f relaxujete doma alebo sa uvo\u013en\u00edte po\u010das vyu\u010dovania. (S l\u00e1skav\u00fdm dovolen\u00edm: Johns Hopkins Medicine)<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Hlavn\u00fd agonista <\/strong>(alebo \"tripper\") <\/em>z Salvia divinorum<\/em> je salvinor\u00edn A. M\u00e1 tie\u017e ve\u013emi jedine\u010dn\u00e1 chemick\u00e1 \u0161trukt\u00fara<\/strong>, na rozdiel od in\u00fdch halucinog\u00e9nov vyskytuj\u00facich sa v pr\u00edrode, ako s\u00fa psilocyb\u00edn, peyotl a DMT. Salvinor\u00edn A sa, samozrejme, chemicky l\u00ed\u0161i aj od laborat\u00f3rne vyroben\u00fdch halucinog\u00e9nov - napr\u00edklad LSD a ketam\u00ednu. <\/p>\n\n\n\n

Salvinor\u00edn A tie\u017e \"zamrzne\"<\/em> na mieste, najm\u00e4 pri vdychovan\u00ed. \u00da\u010dinky mo\u017eno op\u00edsa\u0165 ako z\u00e1\u017eitok podobn\u00fd snu, z\u00e1\u017eitok bl\u00edzky smrti<\/strong>.<\/p>\n\n\n\n

Ak\u00fd siln\u00fd je salvinor\u00edn A v skuto\u010dnosti? <\/p>\n\n\n\n

Salvinor\u00edn A je pri faj\u010den\u00ed <\/strong>the<\/em> <\/strong>najsilnej\u0161\u00ed pr\u00edrodn\u00fd halucinog\u00e9n. Jedin\u00e1 d\u00e1vka u \u013eud\u00ed (od 200 do 1 000 \u03bcg)<\/em> sa vyrovn\u00e1 LSD v tom, ako zasiahne va\u0161e zmysly. V\u00fdlet prich\u00e1dza po 1 min\u00fate<\/strong>a trv\u00e1 15 min\u00fat<\/strong> v priemere. <\/p>\n\n\n\n

Mrknite a zme\u0161k\u00e1te to!<\/p>\n\n\n\n

Psychedelick\u00fd vaping <\/em><\/h2>\n\n\n\n

V \u0161t\u00fadii bolo \u00fa\u010dastn\u00edkom povedan\u00e9, \u017ee dostan\u00fa pomerne vysok\u00e1 d\u00e1vka<\/strong> salvinor\u00ednu A. Predt\u00fdm, ako im bola podan\u00e1 samotn\u00e1 droga, nieko\u013ekokr\u00e1t si precvi\u010dili, ako vapova\u0165, pri\u010dom dostali \u0161peci\u00e1lne pokyny: \"\u013dahnite si na chrb\u00e1t, nasa\u010fte si tienidl\u00e1 na o\u010di a po\u010d\u00favajte hudbu!\"<\/em><\/p>\n\n\n\n

12 mu\u017eov vapovalo kry\u0161t\u00e1liky salvinor\u00ednu A a hne\u010f boli vy\u0161etren\u00ed pomocou fMRI (alebo funk\u010dn\u00e1 magnetick\u00e1 rezonancia<\/strong>) po\u010das nasleduj\u00facich 15 min\u00fat, aby sme zistili, ako v\u00fdlet ovplyvnil ich mozog.<\/p>\n\n\n\n

V\u00fdskumn\u00edci pou\u017eili 8 mozgov\u00fdch siet\u00ed <\/strong>ako v\u00fdchodiskov\u00fa hodnotu, a to: 3 siete pre videnie a 5 \u010fal\u0161\u00edch pre pohyb a dotyk, pozornos\u0165, odmenu a \"predvolen\u00fd re\u017eim siete\"<\/strong> (alebo myse\u013e v pokoji)<\/em>. <\/p>\n\n\n\n

Tu je zauj\u00edmavos\u0165. Dalo by sa o\u010dak\u00e1va\u0165, \u017ee \"symf\u00f3nia\"<\/em> v\u0161etk\u00fdch 8 mozgov\u00fdch siet\u00ed. Salvinor\u00edn A je predsa psychedelikum, nie? <\/p>\n\n\n\n

Vedci v\u0161ak zistili, \u017ee mozgov\u00e9 aktivity nielen pauza<\/strong> <\/em>zatia\u013e sa sign\u00e1ly stali n\u00e1hodn\u00fdmi a nepredv\u00eddate\u013en\u00fdmi. <\/p>\n\n\n\n

(Cik-cak. Zig-zag. Po\u010dkajte, testovan\u00fd subjekt \u010d. 9 sa smeje?<\/em>)<\/p>\n\n\n\n

Potenci\u00e1l na lie\u010dbu z\u00e1vislosti <\/em><\/h2>\n\n\n\n

Salvinor\u00edn A je napriek svojim jasn\u00fdm odli\u0161nostiam od in\u00fdch \"klasick\u00fdch\" psychedel\u00edk st\u00e1le jednou z nov\u00fdch rockov\u00fdch hviezd farmaceutick\u00e9ho priemyslu. <\/em>kv\u00f4li jeho skuto\u010dn\u00e9mu potenci\u00e1lu pri lie\u010dbe z\u00e1vislosti. Iboga\u00edn<\/strong> (pr\u00edbuzn\u00fd salvinor\u00ednu A)<\/em> preuk\u00e1zala \u00fa\u010dinnos\u0165 ako lie\u010dba zneu\u017e\u00edvanie koka\u00ednu a opioidov<\/strong>v predklinickom modeli. <\/p>\n\n\n\n

Vedci \u010doskoro za\u010dn\u00fa nov\u00fa \u0161t\u00fadiu, aby zistili, ako salvinor\u00edn A skuto\u010dne porovn\u00e1va<\/strong> terapeuticky na popul\u00e1rne halucinog\u00e9nne drogy, ako s\u00fa psilocyb\u00edn a LSD. <\/p>\n\n\n\n

\u010co si mysl\u00edte? Je pre \u0161alviu miesto pri stole psychedelickej medic\u00edny? <\/p>\n\n\n\n

Pode\u013ete sa o svoje n\u00e1zory ni\u017e\u0161ie!<\/em><\/p>","protected":false},"excerpt":{"rendered":"

Psychedelik\u00e1 boli v\u017edy spojen\u00e9 so starovek\u00fdmi kult\u00farami.\u00a0<\/p>\n

Mudrci u\u017e\u00edvali psychedelik\u00e1 v ritu\u00e1lnom prostred\u00ed, aby videli v\u00edzie pravdy v dyme a ohni. Domorod\u00ed Mexi\u010dania varili peyotl a kaktus San Pedro a amazonsk\u00e9 kmene pili ayahuascu.<\/p>","protected":false},"author":4,"featured_media":16584,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[68],"tags":[],"topics":[],"class_list":["post-16583","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/16583","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/comments?post=16583"}],"version-history":[{"count":2,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/16583\/revisions"}],"predecessor-version":[{"id":159774,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/16583\/revisions\/159774"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/media\/16584"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/media?parent=16583"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/categories?post=16583"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/tags?post=16583"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/topics?post=16583"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}