{"id":166313,"date":"2023-12-18T15:27:31","date_gmt":"2023-12-18T14:27:31","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=166313"},"modified":"2023-12-18T15:27:35","modified_gmt":"2023-12-18T14:27:35","slug":"mozu-psychedelika-nahradit-opioidy-ako-lieky-proti-bolesti-bez-zavislosti","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/sk\/blog\/can-psychedelics-replace-opioids-as-addiction-free-painkillers\/","title":{"rendered":"M\u00f4\u017eu psychedelik\u00e1 nahradi\u0165 opi\u00e1ty ako lieky proti bolesti bez z\u00e1vislosti?"},"content":{"rendered":"

Na\u0161e mozgy s\u00fa zvl\u00e1\u0161tne veci. Ich \u0161pecifick\u00fd druh m\u00e1gie je v mnoh\u00fdch oh\u013eadoch st\u00e1le nepoznan\u00fd, dokonca aj pre najpokro\u010dilej\u0161\u00edch neurol\u00f3gov. Ale pr\u00e1ve na\u0161e mozgy sprac\u00favaj\u00fa a komunikuj\u00fa boles\u0165, ktor\u00fa c\u00edtime - emocion\u00e1lne aj fyzicky. A v\u010faka t\u00fdmto prepojen\u00fdm mechanizmom spracovania sa hranica medzi t\u00fdmito r\u00f4znymi typmi bolesti stiera.\u00a0<\/strong><\/p>\n\n\n\n

\"\"
cez Pixabay<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Boles\u0165 bez pr\u00ed\u010diny<\/h2>\n\n\n\n

Najviac sa to prejavuje u t\u00fdch, ktor\u00ed trpia nociplastick\u00e1 boles\u0165<\/a>. Nociplastick\u00e1 boles\u0165 je typ bolesti, ktor\u00e1 nem\u00e1 jasn\u00fd alebo zrejm\u00fd sp\u00fa\u0161\u0165a\u010d, \u010d\u00edm sa l\u00ed\u0161i od nocicept\u00edvne<\/a> alebo neuropatick\u00e1 boles\u0165. Je to s\u00fahrnn\u00fd pojem, ktor\u00fd zah\u0155\u0148a stavy od dysfunk\u010dnej bolesti a\u017e po nevysvetlite\u013en\u00e9 telesn\u00e9 syndr\u00f3my. Patr\u00ed k nim fibromyalgia, muskuloskelet\u00e1lna boles\u0165, napr\u00edklad chronick\u00e1 boles\u0165 v kr\u00ed\u017eoch, syndr\u00f3m bolesti mo\u010dov\u00e9ho mech\u00fara a syndr\u00f3m dr\u00e1\u017ediv\u00e9ho \u010dreva. Pre t\u00fdch, ktor\u00ed trpia t\u00fdmito stavmi, to m\u00f4\u017ee by\u0165 mimoriadne traumatizuj\u00face, preto\u017ee nie je zrejm\u00e1 vysledovate\u013en\u00e1 pr\u00ed\u010dina, napr\u00edklad zranenie alebo po\u0161kodenie nervov. To m\u00f4\u017ee vies\u0165 k tomu, \u017ee im nikto never\u00ed, alebo mo\u017eno dokonca spochyb\u0148uj\u00fa svoje vlastn\u00e9 uchopenie reality. <\/p>\n\n\n\n

Probl\u00e9my s opioidmi <\/h4>\n\n\n\n

Mnoh\u00ed z t\u00fdchto \u013eud\u00ed nemaj\u00fa in\u00fa mo\u017enos\u0165, ako siahnu\u0165 po liekoch proti bolesti, ako s\u00fa opioidy. A ako ste u\u017e nepochybne \u010d\u00edtali, epid\u00e9mia opioidov je aktu\u00e1lna pohroma<\/a> zdravotn\u00edckeho syst\u00e9mu. Opioidy s\u00fa z\u00e1rove\u0148 nebezpe\u010dne n\u00e1vykov\u00e9 a z\u00e1rove\u0148 ne\u00fa\u010dinn\u00e9 pri skuto\u010dnej lie\u010dbe z\u00e1kladn\u00fdch pr\u00ed\u010din bolesti. Po\u010diato\u010dn\u00e9 pocity vzru\u0161enia a otupenia bolesti vystrieda rast\u00faca tolerancia a \u017eiadny in\u00fd z\u00e1lo\u017en\u00fd pl\u00e1n ako pokra\u010dova\u0165 v u\u017e\u00edvan\u00ed lieku. <\/p>\n\n\n\n

Ke\u010f sa na to pozrieme t\u00fdmto sp\u00f4sobom, za\u010dne n\u00e1m by\u0165 jasn\u00e9, pre\u010do je sk\u00famanie potenci\u00e1lu psychedel\u00edk pri lie\u010dbe fyzickej aj psychickej bolesti tak\u00e9 d\u00f4le\u017eit\u00e9. D\u00e1va to zmysel, v\u0161ak? Depresia aj chronick\u00e1 boles\u0165 zranen\u00fd. <\/em>M\u00f4\u017eu zni\u010di\u0165 kvalitu n\u00e1\u0161ho \u017eivota. A na\u0161e s\u00fa\u010dasn\u00e9 met\u00f3dy lie\u010dby sp\u00f4sobuj\u00fa, ak v\u00f4bec nie\u010do, viac <\/em>z dlhodob\u00e9ho h\u013eadiska ubl\u00ed\u017ei\u0165. <\/p>\n\n\n\n

\"\"
cez Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Psychedelik\u00e1 sa \u010dasom st\u00e1vaj\u00fa \u00fa\u010dinnej\u0161\u00edmi <\/h2>\n\n\n\n

\u0160t\u00fadie teda op\u00e4\u0165 priniesli s\u013eubn\u00e9 v\u00fdsledky, ktor\u00e9 nazna\u010duj\u00fa, \u017ee psychedelik\u00e1 m\u00f4\u017eu by\u0165 efekt\u00edvne<\/a> pri lie\u010dbe fyzickej bolesti. Tu je v\u0161ak \u010dere\u0161ni\u010dka na torte. Zd\u00e1 sa, \u017ee v priamom protiklade k opioidom sa psychedelik\u00e1 skuto\u010dne st\u00e1vaj\u00fa viac <\/em>\u00fa\u010dinn\u00e1 v priebehu \u010dasu. V\u00fdskum bolesti nervov uk\u00e1zal, \u017ee drogy ako psilocyb\u00edn a LSD, ktor\u00e9 s\u00fa zameran\u00e9 na seroton\u00ednov\u00e9 receptory, pri opakovanom u\u017e\u00edvan\u00ed skuto\u010dne \u010doraz viac zmier\u0148uj\u00fa boles\u0165 a nepr\u00edjemn\u00e9 pocity. <\/p>\n\n\n\n

V ned\u00e1vnom preh\u013ead literat\u00fary<\/a> v\u00fdskumn\u00edci sk\u00famali a porovn\u00e1vali r\u00f4zne \u0161t\u00fadie pokr\u00fdvaj\u00face t\u00fato oblas\u0165 psychedelick\u00e9ho v\u00fdskumu. A zistili, \u017ee hist\u00f3ria psychedelickej lie\u010dby fyzickej bolesti nie je tak\u00e1 nov\u00e1, ako by ste si mohli myslie\u0165. V skuto\u010dnosti v rokoch 1964 a\u017e 1977 prebiehali r\u00f4zne mal\u00e9 klinick\u00e9 \u0161t\u00fadie, ktor\u00e9 uk\u00e1zali, \u017ee LSD m\u00f4\u017ee fungova\u0165 ako \u00fa\u010dinn\u00fd liek proti bolesti. V t\u00fdchto \u0161t\u00fadi\u00e1ch sa dokonca zistilo, \u017ee psychedelik\u00e1 prekonali opioidy pri lie\u010dbe rakoviny a gangr\u00e9ny. Posu\u0148me sa do dne\u0161n\u00fdch dn\u00ed a viac \u013eud\u00ed ako kedyko\u013evek predt\u00fdm si samo lie\u010di ochorenia, ako s\u00fa napr\u00edklad klastrov\u00e9 bolesti hlavy, pomocou psilocyb\u00ednu alebo LSD, pri\u010dom ich pova\u017euj\u00fa za ove\u013ea \u00fa\u010dinnej\u0161ie. <\/p>\n\n\n\n

\"\"
cez Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Pr\u00e1ca s fyzickou aj emocion\u00e1lnou boles\u0165ou naraz<\/h3>\n\n\n\n

Ako sa teda tieto tripov\u00e9 l\u00e1tky dok\u00e1\u017eu vysporiada\u0165 s boles\u0165ou? No psilocyb\u00edn a LSD na rozdiel od opioidov neza\u010d\u00ednaj\u00fa okam\u017eite a priamo manipulova\u0165 s receptormi bolesti. V\u010faka svojmu seroton\u00ednergick\u00e9mu p\u00f4sobeniu v\u0161ak m\u00f4\u017eu by\u0165 ide\u00e1lne na lie\u010dbu nociplastick\u00fdch stavov, ako je IBS, fibromyalgia a komplexn\u00fd region\u00e1lny bolestiv\u00fd syndr\u00f3m. (CRPS). <\/em>Z toho ist\u00e9ho preh\u013eadu literat\u00fary vypl\u00fdva, \u017ee tieto lieky p\u00f4sobia s\u00fa\u010dasne na fyzick\u00fa boles\u0165 aj na p\u00f4vod emocion\u00e1lnych \u0165a\u017ekost\u00ed. <\/p>\n\n\n\n

Psychedelik\u00e1 sa mo\u017eno pr\u00e1ve z tohto d\u00f4vodu stan\u00fa nov\u00fdmi liekmi proti bolesti. Zd\u00e1 sa, \u017ee psilocyb\u00edn a LSD dok\u00e1\u017eu prestava\u0165 mozog sp\u00f4sobom, ktor\u00fd men\u00ed jeho vz\u0165ah k emocion\u00e1lnemu utrpeniu a zni\u017euje jeho vn\u00edmavos\u0165 na sign\u00e1ly fyzickej bolesti. Toto komplikovan\u00e9 nervov\u00e9 preskupenie je rozhoduj\u00face pre lie\u010dbu pacientov s nociplastickou boles\u0165ou, preto\u017ee ich neur\u00f3ny detekuj\u00face boles\u0165 sa ve\u013emi \u013eahko sp\u00fa\u0161\u0165aj\u00fa, \u010do im sp\u00f4sobuje boles\u0165, ktor\u00fa in\u00ed \u013eudia nemusia c\u00edti\u0165. Tento druh citlivosti sa \u010dasto za\u010d\u00edna v\u0161eobecn\u00fdm diskomfortom, ale \u010dasom sa st\u00e1va intenz\u00edvnej\u0161\u00edm. Nakoniec sa pre postihnut\u00e9ho stane neznesite\u013enou. <\/p>\n\n\n\n

Chronick\u00e1 boles\u0165 m\u00f4\u017ee zmeni\u0165 n\u00e1\u0161 mozog<\/h4>\n\n\n\n

Tento stav sa m\u00f4\u017ee r\u00fdchlo zmeni\u0165 z ak\u00fatneho na chronick\u00fd, preto\u017ee bunky sa pos\u00favaj\u00fa, bunkov\u00e9 prote\u00edny sa preskupuj\u00fa a g\u00e9ny za\u010d\u00ednaj\u00fa fungova\u0165 inak. Nakoniec mozog, ktor\u00fd u\u017e nespr\u00e1vne riadi fyzick\u00fa boles\u0165, pokra\u010duje v tom istom aj s na\u0161imi emocion\u00e1lnymi procesmi. To m\u00f4\u017ee vysvet\u013eova\u0165, pre\u010do sa u \u013eud\u00ed trpiacich chronickou boles\u0165ou objavuje aj \u00fazkos\u0165 a\/alebo depresia. <\/p>\n\n\n\n

Chronick\u00e1 boles\u0165 dokonca men\u00ed predvolen\u00fd re\u017eim siete (DMN), <\/em>\u010das\u0165 na\u0161ej mozgovej siete spojen\u00e1 s my\u0161lienkami o na\u0161om \"ja\". \u013dudia trpiaci depresiou aj chronickou nociplatickou boles\u0165ou vykazuj\u00fa nezvy\u010dajne vysok\u00fa aktivitu v DMN a zd\u00e1 sa, \u017ee je odrezan\u00e1 od ostatn\u00fdch \u010dast\u00ed mozgu, ktor\u00e9 spracov\u00e1vaj\u00fa em\u00f3cie a boles\u0165. S\u00favis\u00ed to s posadnutos\u0165ou sebou sam\u00fdm a negat\u00edvnymi my\u0161lienkov\u00fdmi slu\u010dkami. <\/p>\n\n\n\n

\"\"
cez Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Rozmanitos\u0165 mozgu je k\u013e\u00fa\u010dov\u00e1<\/h4>\n\n\n\n

Ke\u010f psychedelik\u00e1 interaguj\u00fa so seroton\u00ednov\u00fdmi receptormi v na\u0161om mozgu, napr\u00edklad s 5-HT2A, zvy\u0161uj\u00fa \"entropiu\" n\u00e1\u0161ho mozgu. Je to ako bohatstvo a rozmanitos\u0165 n\u00e1\u0161ho mozgu - zvy\u0161uje prepojenie s ostatn\u00fdmi \u010das\u0165ami mozgu, \u010do n\u00e1m pom\u00e1ha vymani\u0165 sa z kontroly DMN, ktor\u00e1 je zameran\u00e1 na seba. Predpoklad\u00e1 sa, \u017ee tento proces resetuje n\u00e1\u0161 mozog, \u010do pon\u00faka nov\u00fd sp\u00f4sob lie\u010dby chronickej bolesti aj emocion\u00e1lneho utrpenia. <\/p>\n\n\n\n

Z\u00e1pal je \u010fal\u0161\u00edm k\u013e\u00fa\u010dov\u00fdm faktorom chronickej bolesti a depres\u00edvnych stavov. Uk\u00e1zalo sa, \u017ee psychedelik\u00e1 zmier\u0148uj\u00fa z\u00e1pal, ako aj podporuj\u00fa rast a prepojenie mozgov\u00fdch buniek.<\/p>\n\n\n\n

Celostn\u00e1 lie\u010dba pre uzdravuj\u00faci sa svet<\/h2>\n\n\n\n
\"\"<\/figure>\n\n\n\n

\u010c\u00edm je lek\u00e1rska veda dokonalej\u0161ia, t\u00fdm je jasnej\u0161ie, \u017ee na\u0161e \"ja\" je komplexn\u00e1 kombin\u00e1cia, ktor\u00e1 je zlo\u017een\u00e1 z rovnak\u00fdch \u010dast\u00ed n\u00e1\u0161ho fyzick\u00e9ho tela a na\u0161ej emocion\u00e1lnej a duchovnej podstaty. Myse\u013e nemo\u017eno oddeli\u0165 od tela a telo nemo\u017eno oddeli\u0165 od mysle, ke\u010f ide o \u00fapln\u00e9 uzdravenie. Psychedelik\u00e1 s\u00fa jednou z m\u00e1la l\u00e1tok, ktor\u00e9 n\u00e1s dok\u00e1\u017eu lie\u010di\u0165 holisticky, p\u00f4sobia na na\u0161u myse\u013e, telo a ducha. \u010c\u00edm viac v\u00fdskumov o ich tajomn\u00fdch \u00fa\u010dinkoch urob\u00edme, t\u00fdm lep\u0161ie. <\/p>","protected":false},"excerpt":{"rendered":"

S\u00fa\u010dasn\u00fa vlnu psychedelick\u00e9ho v\u00fdskumu m\u00e1me tendenciu sp\u00e1ja\u0165 s oblas\u0165ou du\u0161evn\u00e9ho zdravia. Depresia, \u00fazkos\u0165, posttraumatick\u00e1 stresov\u00e1 porucha - v\u0161etky tieto stavy sa daj\u00fa v\u00fdrazne zlep\u0161i\u0165 pod\u00e1van\u00edm psychedel\u00edk, napr\u00edklad psilocyb\u00ednu. Ned\u00e1vna \u0161t\u00fadia v\u0161ak odhalila, \u017ee tieto l\u00e1tky dok\u00e1\u017eu lie\u010di\u0165 aj fyzick\u00fa boles\u0165, ako aj du\u0161evn\u00e9 utrpenie. A mo\u017eno tieto dve veci spolu s\u00favisia viac, ako ste si p\u00f4vodne mysleli...<\/p>","protected":false},"author":4,"featured_media":167391,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88,68],"tags":[],"topics":[],"class_list":["post-166313","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-studies","category-science-and-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/166313","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/comments?post=166313"}],"version-history":[{"count":11,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/166313\/revisions"}],"predecessor-version":[{"id":167398,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/166313\/revisions\/167398"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/media\/167391"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/media?parent=166313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/categories?post=166313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/tags?post=166313"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/topics?post=166313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}