{"id":188827,"date":"2024-04-22T16:50:12","date_gmt":"2024-04-22T14:50:12","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=188827"},"modified":"2024-04-22T16:50:24","modified_gmt":"2024-04-22T14:50:24","slug":"studia-zistila-ze-psilocybin-moze-byt-ucinnou-liecbou-cukrovky","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/sk\/blog\/study-finds-psilocybin-may-be-an-effective-treatment-for-diabetes\/","title":{"rendered":"\u0160t\u00fadia zistila, \u017ee psilocyb\u00edn m\u00f4\u017ee by\u0165 \u00fa\u010dinnou lie\u010dbou cukrovky"},"content":{"rendered":"

V posledn\u00fdch rokoch, psilocyb\u00edn<\/a> (psychoakt\u00edvna zl\u00fa\u010denina v magick\u00fdch hub\u00e1ch a h\u013euzovk\u00e1ch) <\/em>sa za\u010dal uzn\u00e1va\u0165 jeho terapeutick\u00fd potenci\u00e1l, najm\u00e4 pri du\u0161evn\u00fdch poruch\u00e1ch. Zistenia s\u00fa tak\u00e9 s\u013eubn\u00e9, \u017ee sa teraz dokonca sk\u00fama v s\u00favislosti s lie\u010dbou fyzick\u00e1 boles\u0165<\/a>s \u00faspe\u0161n\u00fdmi v\u00fdsledkami. Vzh\u013eadom na to, \u017ee mnoh\u00e9 z jeho mechanizmov s\u00fa st\u00e1le z\u00e1hadou, nie je divu, \u017ee vedci zo v\u0161etk\u00fdch odborov t\u00fa\u017eia sk\u00fama\u0165 \u010fal\u0161ie vyu\u017eitie psilocyb\u00ednu.<\/strong><\/p>\n\n\n\n

To sa odr\u00e1\u017ea v vzru\u0161uj\u00faca nov\u00e1 \u0161t\u00fadia<\/a>, uverejnen\u00e9 v \u010dasopise G\u00e9ny<\/em>, ktor\u00e1 sk\u00fama mo\u017enos\u0165 pou\u017eitia psilocyb\u00ednu ako lie\u010dby cukrovky. Autor \u0161t\u00fadie Igor Koval\u010duk vysvetlil;<\/p>\n\n\n\n

\"Diabetes a metabolick\u00fd syndr\u00f3m su\u017euj\u00fa spolo\u010dnos\u0165 a my sme h\u013eadali r\u00f4zne sp\u00f4soby, ako prispie\u0165 k boju proti t\u00fdmto ochoreniam... Ke\u010f\u017ee mikrod\u00e1vkovanie hubami by sa mohlo sta\u0165 jednou z mo\u017enost\u00ed lie\u010dby r\u00f4znych ochoren\u00ed, chceli sme otestova\u0165, \u010di ich \u00fa\u010dinn\u00e1 l\u00e1tka, psilocyb\u00edn, bude ma\u0165 aj antidiabetick\u00e9 \u00fa\u010dinky.\"<\/em><\/p>\n\n\n\n

\"\"
prostredn\u00edctvom Creative Commons<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Psilocyb\u00edn: Seroton\u00ednov\u00fd na\u0161epk\u00e1va\u010d<\/h2>\n\n\n\n

A rozhodne to nie je len psychedelick\u00e9 sk\u00e1kanie po kapele. Psilocyb\u00edn interaguje so seroton\u00ednov\u00fdmi receptormi v mozgu, \u010do je jeden z mnoh\u00fdch sp\u00f4sobov, ako sa \u00fa\u010dinn\u00e1 ako lie\u010dba du\u0161evn\u00e9ho zdravia<\/a>. Vedeli ste v\u0161ak, \u017ee seroton\u00ednov\u00e9 receptory m\u00e1me aj v pankrease, kde sa produkuje inzul\u00edn? Pri produkcii inzul\u00ednu (alebo ich nedostatok) <\/em>ke\u010f\u017ee je jadrom toho, \u010do sp\u00f4sobuje cukrovku, mohol by jedine\u010dn\u00fd s\u00fabor schopnost\u00ed psilocyb\u00ednu zmeni\u0165 hru?<\/p>\n\n\n\n

\u010co sp\u00f4sobuje cukrovku? <\/h3>\n\n\n\n

Cukrovka je chronick\u00e1 metabolick\u00e1 porucha, ktor\u00e1 vznik\u00e1 vtedy, ke\u010f pankreas prestane produkova\u0165 inzul\u00edn alebo ke\u010f telo u\u017e nedok\u00e1\u017ee \u00fa\u010dinne vyu\u017e\u00edva\u0165 produkovan\u00fd inzul\u00edn. Inzul\u00edn je horm\u00f3n, ktor\u00fd premie\u0148a gluk\u00f3zu z prijatej potravy na energiu, ktor\u00fa m\u00f4\u017eu vyu\u017ei\u0165 na\u0161e bunky. Ke\u010f na\u0161e telo nedok\u00e1\u017ee \u00fa\u010dinne produkova\u0165 alebo pou\u017e\u00edva\u0165 inzul\u00edn, vedie to k vysokej hladine gluk\u00f3zy v krvi, ktor\u00e1 sa naz\u00fdva hyperglyk\u00e9mia. <\/em>Tieto vysok\u00e9 hladiny gluk\u00f3zy v krvi m\u00f4\u017eu \u010dasom po\u0161kodi\u0165 organizmus a sp\u00f4sobi\u0165 zlyhanie r\u00f4znych org\u00e1nov a tkan\u00edv. Pod\u013ea autorov \u0161t\u00fadie teda psilocyb\u00edn interakciou so seroton\u00ednov\u00fdmi bunkami v pankrease m\u00f4\u017ee zabr\u00e1ni\u0165 strate \u017eivotne d\u00f4le\u017eit\u00fdch buniek produkuj\u00facich inzul\u00edn. <\/p>\n\n\n\n

\"\"
Foto: Matt C on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Ako \u0161t\u00fadia fungovala<\/h4>\n\n\n\n

V \u0161t\u00fadii vedci sk\u00famali \u00fa\u010dinky psilocyb\u00ednu na \u03b2-bunky pankreasu. Pankreatick\u00e9 \u03b2-bunky s\u00fa bunky zodpovedn\u00e9 za produkciu inzul\u00ednu. Ke\u010f s\u00fa naru\u0161en\u00e9, ako napr\u00edklad u diabetika, schopnos\u0165 tela regulova\u0165 hladinu cukru v krvi je naru\u0161en\u00e1. <\/p>\n\n\n\n

V\u00fdskumn\u00edci vystavili \u03b2-bunky pankreasu vysok\u00e9mu obsahu gluk\u00f3zy a lipidov (tuk) <\/em>stav, ktor\u00fd odr\u00e1\u017ea metabolick\u00fd stres sp\u00f4soben\u00fd cukrovkou. Pou\u017eili bunkov\u00e1 l\u00ednia inzulin\u00f3mu potkana<\/a>, vedeck\u00fd model pou\u017e\u00edvan\u00fd vzh\u013eadom na jeho v\u00fdznam pre funkciu \u013eudsk\u00fdch \u03b2-buniek. <\/p>\n\n\n\n

Po kultiv\u00e1cii v m\u00e9diu bohatom na \u017eiviny boli niektor\u00e9 bunky o\u0161etren\u00e9 \u0161pecifickou koncentr\u00e1ciou psilocyb\u00ednu. Po lie\u010dbe psilocyb\u00ednom boli bunky ponoren\u00e9 do podmienok s vysok\u00fdm obsahom gluk\u00f3zy a lipidov, ktor\u00e9 boli vypo\u010d\u00edtan\u00e9 tak, aby vyvolali z\u00e1\u0165a\u017e a po\u0161kodenie v\u0161eobecne pozorovan\u00e9 v \u03b2-bunk\u00e1ch pankreasu \u013eud\u00ed s cukrovkou. <\/p>\n\n\n\n

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Foto: Julia Koblitz on Unsplash<\/mark><\/em><\/figcaption><\/figure>\n\n\n\n

Psilocyb\u00edn chr\u00e1ni bunky<\/h3>\n\n\n\n

Vedci zistili, \u017ee bunky, ktor\u00e9 boli lie\u010den\u00e9 psilocyb\u00ednom, vykazovali v\u00fdrazne lep\u0161iu \u017eivotaschopnos\u0165 v porovnan\u00ed s bunkami, ktor\u00e9 psilocyb\u00ednom lie\u010den\u00e9 neboli. Toto zistenie nazna\u010duje, \u017ee psilocyb\u00edn m\u00e1 ochrann\u00fd \u00fa\u010dinok na \u03b2-bunky pankreasu, \u010do pom\u00e1ha zmierni\u0165 po\u0161kodenie metabolick\u00fdm stresom spojen\u00fdm s cukrovkou. <\/p>\n\n\n\n

Pri \u010fal\u0161ej anal\u00fdze vedci zistili, pre\u010do m\u00f4\u017ee ma\u0165 psilocyb\u00edn tieto ochrann\u00e9 \u00fa\u010dinky. PomocouWestern Blot<\/a>' anal\u00fdza zistila, \u017ee lie\u010dba psilocyb\u00ednom viedla k poklesu nieko\u013ek\u00fdch k\u013e\u00fa\u010dov\u00fdch apoptotick\u00fdch biomarkerov v \u03b2-bunk\u00e1ch, ktor\u00e9 boli vystaven\u00e9 vysok\u00fdm hladin\u00e1m gluk\u00f3zy a lipidov, ktor\u00e9 imituj\u00fa diabetes. Apopt\u00f3za<\/a> (\u010do znamen\u00e1 programovan\u00fa bunkov\u00fa smr\u0165) <\/em>zohr\u00e1va k\u013e\u00fa\u010dov\u00fa \u00falohu pri strate \u03b2-buniek pri cukrovke. Pozorovan\u00e1 schopnos\u0165 psilocyb\u00ednu zni\u017eova\u0165 markery spojen\u00e9 s t\u00fdmto procesom zd\u00f4raz\u0148uje jeho potenci\u00e1l zachra\u0148ova\u0165 \u03b2-bunky pri cukrovke. <\/p>\n\n\n\n

V reakcii na vzru\u0161uj\u00face zistenia svojho t\u00edmu Koval\u010duk poznamenal;<\/p>\n\n\n\n

\"Neo\u010dak\u00e1vali sme, \u017ee psilocyb\u00edn bude tak dobre p\u00f4sobi\u0165 na bunky pankreasu,\" <\/em><\/p>\n\n\n\n

PsyPostu tie\u017e povedal, \u017ee;<\/p>\n\n\n\n

\"...mikrod\u00e1vkovanie magick\u00fdch h\u00fab bude ma\u0165 pravdepodobne pozit\u00edvny \u00fa\u010dinok na \u013eud\u00ed s metabolick\u00fdm syndr\u00f3mom (prediabetes) a cukrovkou,\"<\/em><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Obmedzenia \u0161t\u00fadie: Za\u010diatky<\/h4>\n\n\n\n

Hoci ide o s\u013eubn\u00fd za\u010diatok v tejto oblasti v\u00fdskumu, \u0161t\u00fadia m\u00e1 ur\u010dit\u00e9 obmedzenia, ktor\u00e9 nazna\u010duj\u00fa potrebu \u010fal\u0161\u00edch v\u00fdskumn\u00fdch projektov. Najm\u00e4, samozrejme, to, \u017ee \u0161t\u00fadia bola vykonan\u00e1 s pou\u017eit\u00edm bunkovej l\u00ednie inzulin\u00f3mu potkana, ktor\u00e1 je s\u00edce vhodn\u00e1 na ve\u013emi skor\u00e9 v\u00fdskumy, ale nie je schopn\u00e1 plne kop\u00edrova\u0165 zlo\u017eitos\u0165 \u017eiv\u00e9ho organizmu. <\/p>\n\n\n\n

Kova\u013e\u010duk poznamenal; \"Mus\u00edme t\u00fato \u0161t\u00fadiu vykona\u0165 na zvierat\u00e1ch, aby sme si boli ist\u00ed, \u017ee funguje rovnako dobre ako in vitro,\" <\/em><\/p>\n\n\n\n

Okrem toho sa t\u00e1to \u0161t\u00fadia zaoberala len \u00fa\u010dinkami psilocyb\u00ednu v \u0161pecifick\u00fdch podmienkach stresu vyvolan\u00e9ho vysokou hladinou gluk\u00f3zy a vysok\u00fdm obsahom lipidov. Predstavuje to len jeden aspekt diabetu, ktor\u00fd je multifaktori\u00e1lnym ochoren\u00edm, \u010do znamen\u00e1, \u017ee vykazuje \u0161irok\u00fa \u0161k\u00e1lu patologick\u00fdch javov vr\u00e1tane z\u00e1palu, inzul\u00ednovej rezistencie a v pr\u00edpade diabetu 1. typu aj autoimunitn\u00fdch zlo\u017eiek.<\/p>\n\n\n\n

Revol\u00facia v lie\u010dbe cukrovky<\/h3>\n\n\n\n

T\u00e1to \u0161t\u00fadia v podstate poukazuje na mo\u017en\u00fa revol\u00faciu v lie\u010dbe cukrovky. Je to ve\u013emi d\u00f4le\u017eit\u00e9, preto\u017ee ide o ochorenie, ktor\u00e9 sa mus\u00ed lie\u010di\u0165 po\u010das cel\u00e9ho \u017eivota. V mnoh\u00fdch krajin\u00e1ch s\u00fa lieky potrebn\u00e9 na udr\u017eanie zdravia diabetika drah\u00e9 a pre \u013eud\u00ed s ni\u017e\u0161\u00edmi pr\u00edjmami \u010dasto obetovan\u00e9 namiesto jedla alebo n\u00e1jomn\u00e9ho. Ako hovor\u00ed Kolvachuk \"V\u017edy h\u013ead\u00e1me prirodzenej\u0161ie\/tradi\u010dn\u00e9\/holistick\u00e9 sp\u00f4soby lie\u010dby chor\u00f4b.\"<\/em><\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Mohol by tento v\u00fdskum pripravi\u0165 p\u00f4du pre bud\u00facnos\u0165, v ktorej by \u013eudia mohli riadi\u0165 svoje zdravie pestovan\u00edm vlastn\u00fdch pr\u00edrodn\u00fdch liekov? <\/strong><\/p>\n\n\n\n

D\u00fafame!\u00a0<\/strong>????<\/p>","protected":false},"excerpt":{"rendered":"

Diabetes je ochorenie, ktor\u00fdm v s\u00fa\u010dasnosti trp\u00ed 537 mili\u00f3nov \u013eud\u00ed na celom svete, a tento po\u010det sa neust\u00e1le zvy\u0161uje. Vzh\u013eadom na to, \u017ee do roku 2045 bude ma\u0165 cukrovku 783 mili\u00f3nov \u013eud\u00ed, je potrebn\u00e9 vyvin\u00fa\u0165 \u00fa\u010dinnej\u0161iu a dostupnej\u0161iu lie\u010dbu. Nov\u00e1 \u0161t\u00fadia nazna\u010duje, \u017ee magick\u00e9 huby by v tom mohli zohr\u00e1va\u0165 d\u00f4le\u017eit\u00fa \u00falohu.\u00a0<\/p>","protected":false},"author":4,"featured_media":189850,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88],"tags":[],"topics":[],"class_list":["post-188827","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/188827","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/comments?post=188827"}],"version-history":[{"count":13,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/188827\/revisions"}],"predecessor-version":[{"id":189860,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/188827\/revisions\/189860"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/media\/189850"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/media?parent=188827"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/categories?post=188827"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/tags?post=188827"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/topics?post=188827"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}