{"id":47545,"date":"2022-02-22T11:09:07","date_gmt":"2022-02-22T10:09:07","guid":{"rendered":"https:\/\/www.wholecelium.com\/?p=47545"},"modified":"2023-05-10T08:03:45","modified_gmt":"2023-05-10T06:03:45","slug":"studie-ukazuju-ze-ssris-nezastavuje-posobenie-psilocybinu","status":"publish","type":"post","link":"https:\/\/www.wholecelium.com\/sk\/blog\/studies-show-ssris-do-not-stop-psilocybin-working\/","title":{"rendered":"\u0160t\u00fadie ukazuj\u00fa, \u017ee SSRI nezastavuj\u00fa p\u00f4sobenie psilocyb\u00ednu"},"content":{"rendered":"<p><\/p>\n\n<p style=\"font-size: 27px\"><strong>\u00a0T\u00e1to l\u00e1tka, ktor\u00e1 sa v\u010faka vedeck\u00fdm \u0161t\u00fadi\u00e1m a v\u00fdskumom dostala vysoko do popredia a bola predt\u00fdm zara\u010fovan\u00e1 medzi nebezpe\u010dn\u00e9 drogy, ako s\u00fa hero\u00edn a koka\u00edn, sa u\u017e d\u00e1vno do\u010dkala zmeny imid\u017eu.\u00a0<\/strong><\/p>\n<p>\u00a0<\/p>\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<figure><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/Magic-mushrooms-with-SSRIs.jpg\" alt=\"\" width=\"840\" height=\"472\"><p><\/p>\n<figcaption><mark><em>prostredn\u00edctvom Creative Commons<\/em><\/mark><\/figcaption>\n<\/figure>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-a-bitter-irony-for-those-with-depression\">Trpk\u00e1 ir\u00f3nia pre \u013eud\u00ed s depresiou<\/h2>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Naozaj to nem\u00f4\u017ee pr\u00eds\u0165 dos\u0165 r\u00fdchlo. Nielen\u017ee je dos\u0165 \u0161ialen\u00e9, \u017ee l\u00e1tka s hodnoten\u00edm<a href=\"https:\/\/www.sciencealert.com\/researchers-rank-recreational-drugs-based-on-how-dangerous-they-are\" target=\"_blank\" rel=\"noreferrer noopener\"> najmenej nebezpe\u010dn\u00e1 rekrea\u010dn\u00e1 droga<\/a><em> (s<\/em><strong><em> ve\u013emi lega<\/em><\/strong><em>l alkoholu najmenej 10x vy\u0161\u0161ia pravdepodobnos\u0165, \u017ee sa dostanete do probl\u00e9mov!)<\/em> je st\u00e1le zak\u00e1zan\u00e1, na celom svete s\u00fa mili\u00f3ny \u013eud\u00ed, ktor\u00ed by mohli ma\u0165 prospech z k\u00fazla psilocyb\u00ednu.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Doteraz sa t\u00e1to z\u00e1zra\u010dn\u00e1 zl\u00fa\u010denina pou\u017e\u00edvala na lie\u010dbu stavov od <a href=\"https:\/\/www.wholecelium.com\/sk\/blog\/mozu-psychedelika-liecit-dusevne-choroby-nadobro\/\">depresia<\/a>,&nbsp;<a href=\"https:\/\/www.wholecelium.com\/sk\/blog\/huby-pomahaju-vojakom-bojovat-s-poruchou-psychickej-stability\/\" target=\"_blank\" rel=\"noopener\">PTSD<\/a>, \u00fazkos\u0165,&nbsp;<a href=\"https:\/\/www.wholecelium.com\/sk\/blog\/prestat-fajcit-s-magickymi-hubami\/\" target=\"_blank\" rel=\"noopener\">z\u00e1vislos\u0165<\/a>a poruchy pr\u00edjmu potravy. Je to naozaj vzru\u0161uj\u00face. A\u017e doned\u00e1vna v\u0161ak bolo <strong>trpk\u00e1 ir\u00f3nia<\/strong> pripojen\u00e9 k tomuto rast\u00facemu \u00faspechu. Dlho platilo, \u017ee \u017eiaduce \u00fa\u010dinky psilocyb\u00ednu sa tlmia u\u017e\u00edvan\u00edm tradi\u010dn\u00fdch antidepres\u00edv a liekov proti \u00fazkosti. Hlavn\u00fd d\u00f4raz sa kl\u00e1dol na <em>Selekt\u00edvne inhib\u00edtory sp\u00e4tn\u00e9ho vychyt\u00e1vania seroton\u00ednu<\/em> alebo \"SSRI\".&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/SSRIs-pills.jpg\" alt=\"\" width=\"840\" height=\"436\"><p><\/p>\n<figcaption><em><mark>Foto: Nastya Dulhiier on Unsplash<\/mark><\/em><\/figcaption>\n<\/figure>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Prem\u00fd\u0161\u013eajte o tom... t\u00fdm, ktor\u00ed najviac t\u00fa\u017eia po pomoci, ktor\u00fa psilocyb\u00edn poskytuje, br\u00e1nia lieky, ktor\u00e9 v s\u00fa\u010dasnosti u\u017e\u00edvaj\u00fa. Hovor\u00edme o nespravodlivosti!<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-the-problems-with-ssris\">Probl\u00e9my s SSRI<\/h2>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Existuje mnoho d\u00f4vodov, pre\u010do by niekto mohol chcie\u0165 presta\u0165 u\u017e\u00edva\u0165 tradi\u010dn\u00e9 farmaceutick\u00e9 lieky. Samozrejme, \u017ee u mnoh\u00fdch \u013eud\u00ed funguj\u00fa. Ale u mnoh\u00fdch \u013eud\u00ed nefunguj\u00fa. M\u00f4\u017ee sa sta\u0165, \u017ee nemaj\u00fa \u017eiadny alebo maj\u00fa ve\u013emi mal\u00fd \u00fa\u010dinok. \u017de vytv\u00e1raj\u00fa emocion\u00e1lnu otupenos\u0165, ktor\u00e1 sa ned\u00e1 vydr\u017ea\u0165. \u017de mnoh\u00e9 ved\u013eaj\u0161ie \u00fa\u010dinky s\u00fa pr\u00edli\u0161 ve\u013ek\u00e9 na to, aby sa dali zvl\u00e1dnu\u0165. Alebo aj to, \u017ee u\u017e\u00edvate\u013e nechce do svojho tela vklada\u0165 neprirodzen\u00e9 chemick\u00e9 l\u00e1tky.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Akoko\u013evek s nimi m\u00f4\u017eu niektor\u00ed ich pou\u017e\u00edvatelia bojova\u0165, pre mnoh\u00fdch s\u00fa to bu\u010f lieky - alebo trpia najzni\u010duj\u00facej\u0161ou verziou svojej depresie alebo \u00fazkosti. To ohrozuje ich vlastn\u00fa bezpe\u010dnos\u0165, ako aj vz\u0165ahy s bl\u00edzkymi a profesion\u00e1lne z\u00e1v\u00e4zky.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<figure><img decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/gadiel-lazcano-ulPAVuxITEw-unsplash.jpg\" alt=\"\" width=\"841\" height=\"416\"><p><\/p>\n<figcaption><mark><em>Foto: Gadiel Lazcano on Unsplash<\/em><\/mark><\/figcaption>\n<\/figure>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Psilocyb\u00edn aj SSRI interaguj\u00fa s neurotransmiterom <a href=\"https:\/\/en.wikipedia.org\/wiki\/Serotonin\" target=\"_blank\" rel=\"noreferrer noopener\">seroton\u00edn<\/a>, ale ve\u013emi odli\u0161n\u00fdm sp\u00f4sobom. SSRI zachyt\u00e1vaj\u00fa seroton\u00edn v mozgu a \u010dasto m\u00f4\u017eu otupi\u0165 emocion\u00e1lnu reakciu. Naproti tomu psilocyb\u00edn sa via\u017ee na receptory a stimuluje ich, \u010d\u00edm vlastne zvy\u0161uje emocion\u00e1lne spojenie.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Predt\u00fdm sa odpor\u00fa\u010dalo, aby si u\u017e\u00edvate\u013e SSRI pred za\u010dat\u00edm lie\u010dby psilocyb\u00ednom vysadil. Pre mnoh\u00fdch u\u017e\u00edvate\u013eov je to probl\u00e9m, preto\u017ee za\u017eij\u00fa zna\u010dn\u00fd fyzick\u00fd a psychick\u00fd abstinen\u010dn\u00fd stav, ako aj n\u00e1vrat pr\u00edznakov svojho ochorenia. Je to ve\u013ea, najm\u00e4 ke\u010f je po\u017eadovan\u00e1 lie\u010dba na mnoh\u00fdch miestach neleg\u00e1lna alebo \u0165a\u017eko dostupn\u00e1.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-new-studies-show-you-can-combine-ssris-and-psilocybin\">Nov\u00e9 \u0161t\u00fadie ukazuj\u00fa, \u017ee m\u00f4\u017eete kombinova\u0165 SSRI a psilocyb\u00edn<\/h2>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Preto s najvy\u0161\u0161\u00edm nad\u0161en\u00edm m\u00f4\u017eeme ozn\u00e1mi\u0165, \u017ee dve ned\u00e1vne \u0161t\u00fadie, ktor\u00e9 boli publikovan\u00e9 v priebehu nieko\u013ek\u00fdch t\u00fd\u017ed\u0148ov na konci roka 2021, nazna\u010duj\u00fa, \u017ee ide skuto\u010dne o <em>nie <\/em>pr\u00edpad. SSRI a psilocyb\u00edn m\u00f4\u017eete kombinova\u0165 bez negat\u00edvnych \u00fa\u010dinkov na obe l\u00e1tky!&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Najsk\u00f4r biotechnologick\u00e1 spolo\u010dnos\u0165<a href=\"https:\/\/mindmed.co\/\" target=\"_blank\" rel=\"noreferrer noopener\"> MindMed<\/a>, ktor\u00fd v novembri 2021 zverejnil \u00fadaje, ktor\u00e9 uk\u00e1zali, ako psilocyb\u00edn a SSRI p\u00f4sobia na \u013eud\u00ed. \u0160t\u00fadia, ktor\u00fa uskuto\u010dnila Univerzitn\u00e1 nemocnica v Bazileji, zistila, \u017ee \u00fa\u010dastn\u00edci, ktor\u00ed u\u017e\u00edvali SSRI <em>escitalopram<\/em> st\u00e1le poci\u0165ovali pozit\u00edvne \u00fa\u010dinky psilocyb\u00ednu na n\u00e1ladu. V porovnan\u00ed so skupinou u\u017e\u00edvaj\u00facou placebo sa u nich zn\u00ed\u017eil aj potenci\u00e1l negat\u00edvnych \u00fa\u010dinkov, ktor\u00e9 psilocyb\u00edn m\u00f4\u017ee sp\u00f4sobova\u0165, ako napr\u00edklad \u00fazkos\u0165.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<figure><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/jesse-orrico-rmWtVQN5RzU-unsplash.jpg\" alt=\"\" width=\"839\" height=\"556\"><p><\/p>\n<figcaption><mark><em>Foto: jesse orrico on Unsplash<\/em><\/mark><\/figcaption>\n<\/figure>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>V \u0161t\u00fadii niektor\u00ed \u00fa\u010dastn\u00edci dost\u00e1vali bu\u010f 10 mg escitalopramu denne po\u010das siedmich dn\u00ed, potom 20 mg denne po\u010das nasleduj\u00facich siedmich dn\u00ed, vr\u00e1tane d\u0148a podania psilocyb\u00ednu. Ostatn\u00ed dva t\u00fd\u017edne placebo a\u017e do podania psilocyb\u00ednu.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-answering-key-questions\">Odpovede na k\u013e\u00fa\u010dov\u00e9 ot\u00e1zky<\/h2>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Hlavn\u00fd v\u00fdskumn\u00edk \u0161t\u00fadie, Dr. Matthias Liechti, vysvetlil ot\u00e1zky, na ktor\u00e9 chceli v\u00fdskumom odpoveda\u0165:<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p><em>\"Po prv\u00e9, mal by pacient z bezpe\u010dnostn\u00fdch d\u00f4vodov presta\u0165 u\u017e\u00edva\u0165 antidepres\u00edva pred podan\u00edm psilocyb\u00ednu? Po druh\u00e9, ak neexistuje bezpe\u010dnostn\u00e9 riziko, zn\u00ed\u017ei antidepres\u00edvum reakciu pacienta na psilocyb\u00edn?\"<\/em><\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>A dok\u00e1zali na ne odpoveda\u0165:<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p><em>\"Tieto v\u00fdsledky nazna\u010duj\u00fa, \u017ee psilocyb\u00edn sa m\u00f4\u017ee d\u00e1vkova\u0165 po\u010das lie\u010dby escitalopramom bez zjavn\u00e9ho vplyvu na \u00fa\u010dinok psilocyb\u00ednu. \u0160t\u00fadia teda odpoved\u00e1 na prv\u00fa ot\u00e1zku a poskytuje pozit\u00edvnu indik\u00e1ciu pre druh\u00fa.\" (Dr. Liechti)&nbsp;<\/em><\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Je to dobr\u00fd prv\u00fd krok a naliehav\u00fd podnet na \u010fal\u0161ie \u0161t\u00fadie, ako uviedla Dr. Miri Halperin Wernli, v\u00fdkonn\u00e1 prezidentka spolo\u010dnosti MindMed;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p><em>\"Ak sa v\u00fdsledky potvrdia v \u010fal\u0161\u00edch \u0161t\u00fadi\u00e1ch s in\u00fdmi l\u00e1tkami a sk\u00f4r na pacientoch ako na zdrav\u00fdch jedincoch, mo\u017eno u\u017e nebude potrebn\u00e9 vysadi\u0165 antidepres\u00edva pri lie\u010dbe psilocyb\u00ednom,\"&nbsp;<\/em><\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-compass-pathways-find-the-same-result\">Compass Pathways n\u00e1jde rovnak\u00fd v\u00fdsledok<\/h2>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>A keby ste to nevedeli? V priebehu nieko\u013ek\u00fdch t\u00fd\u017ed\u0148ov <a href=\"https:\/\/compasspathways.com\/\" target=\"_blank\" rel=\"noreferrer noopener\">Compass Pathways<\/a> zverejnili svoje vlastn\u00e9 \u00fadaje s \u010fal\u0161\u00edmi po\u017eadovan\u00fdmi d\u00f4kazmi...<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>V \u0161t\u00fadii Compass Pathways sa zistili porovnate\u013en\u00e9 v\u00fdsledky u \u00fa\u010dastn\u00edkov, ktor\u00ed st\u00e1le u\u017e\u00edvali SSRI, a u t\u00fdch, ktor\u00ed ich u\u017e\u00edvanie pred \u0161t\u00fadiou ukon\u010dili, ke\u010f im boli podan\u00e9 <em>COMP360.  COMP360 <\/em>je nov\u00e1 extrakcia psilocyb\u00ednu vytvoren\u00e1 spolo\u010dnos\u0165ou Compass Pathways \u0161peci\u00e1lne na terapeutick\u00e9 pou\u017eitie.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Hlavn\u00fd lek\u00e1r spolo\u010dnosti Compass Pathways Guy Goodwin uviedol:<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p><em>\"V\u00fdsledky tejto \u0161t\u00fadie spochyb\u0148uj\u00fa v\u0161eobecne roz\u0161\u00edren\u00fd n\u00e1zor, \u017ee u\u017e\u00edvanie liekov SSRI spolu s psilocyb\u00ednom by mohlo naru\u0161i\u0165 terapeutick\u00fd \u00fa\u010dinok psilocyb\u00ednu. Na\u0161e zistenia poskytuj\u00fa siln\u00fd sign\u00e1l, \u017ee terapia psilocyb\u00ednom COMP360 by mohla by\u0165 doplnkovou lie\u010dbou k antidepres\u00edvam SSRI, ako aj monoterapiou.\"<\/em><\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>A<em> <\/em>\"monoterapia\" je <strong>jeden liek <\/strong>lie\u010dba. Tak\u017ee to, \u010do je <em>hovor\u00ed <\/em>je, \u017ee psilocyb\u00edn by mohol by\u0165 pou\u017eit\u00fd ako jedin\u00e1 lie\u010dba <em>(ako sme vedeli)<\/em> <em><strong>a<\/strong> <\/em>spolu so SSRI.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<h2 class=\"wp-block-heading\" id=\"h-magic-mushroom-myth-busting\">Magick\u00e9 huby - b\u00faranie m\u00fdtov!<\/h2>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Uff! Docela dos\u0165 m\u00fdtov sa deje. Je to skvel\u00e1 spr\u00e1va pre t\u00fdch, ktor\u00ed v s\u00fa\u010dasnosti u\u017e\u00edvaj\u00fa SSRI a chc\u00fa podst\u00fapi\u0165 lie\u010dbu psilocyb\u00ednom - \u010dasto s\u00fa to t\u00ed, ktor\u00ed to najviac potrebuj\u00fa.&nbsp;<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p>Sledujte tento priestor pre \u010fal\u0161ie pozit\u00edvne zistenia!<\/p>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<figure><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.wholecelium.com\/wp-content\/uploads\/19.png\" alt=\"\" width=\"341\" height=\"341\"><\/figure>\n<p>\n\n\n<p><\/p>\n<p><\/p>\n\n\n<\/p>\n<p><em>A medzit\u00fdm sa v\u017edy pora\u010fte so svoj\u00edm lek\u00e1rom, ak pl\u00e1nujete zmeni\u0165 svoje lieky alebo zdravotn\u00fd re\u017eim.<\/em>.<\/p>\n<p>\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Psilocyb\u00edn - \u00fa\u010dinn\u00e1 l\u00e1tka magick\u00fdch h\u00fab a h\u013euzoviek - je u\u017e nieko\u013eko rokov pova\u017eovan\u00fd za ve\u013ek\u00fa n\u00e1dej v lie\u010dbe du\u0161evn\u00e9ho zdravia.<\/p>","protected":false},"author":4,"featured_media":47646,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88],"tags":[],"topics":[],"class_list":["post-47545","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-psychedelic-studies"],"_links":{"self":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/47545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/comments?post=47545"}],"version-history":[{"count":2,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/47545\/revisions"}],"predecessor-version":[{"id":123347,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/posts\/47545\/revisions\/123347"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/media\/47646"}],"wp:attachment":[{"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/media?parent=47545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/categories?post=47545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/tags?post=47545"},{"taxonomy":"topics","embeddable":true,"href":"https:\/\/www.wholecelium.com\/sk\/wp-json\/wp\/v2\/topics?post=47545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}